“…This reaction is accompanied by the formation of sulfite, thiosulfate and sulfate, consumes oxygen and is partially inhibited by the superoxide scavenger, tempol, and superoxide dismutase but not mannitol, trolox, DMPO, or the iron chelator, desferrioxamine. We propose that the reaction proceeds via a one-electron autoxidation process during which one of the OH-groups of the catechin B-ring is autooxidized to a semiquinone radical and oxygen is reduced to superoxide, either of which can then oxidize HS(−) to thiyl radicals (HS(•)) which react to form hydrogen persulfide (H(2)S(2)). …”
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“…Growing iron-deficient plants at high pH also modulated the transcriptional iron deficiency response observed at pH 5.5 by compromising the enzymatic reduction of ferric chelates and favoring the production of iron-mobilizing coumarins. …”
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“…The reaction of 1 with [W(CO)(4)(nbd)] (nbd=norbornadiene) yields the complex [{Cp*Cr(CO)(3)}(2)(μ(3),η(1:1:1:1)‐P(4)){W(CO)(4)}] (2) in which 1 serves as a chelating P(4) butterfly ligand. In contrast, reactions of 1 with [M(CO)(4)(nbd)] (M=Cr (a), Mo (b)) result in the step‐wise formation of [{Cp*Cr(CO)(2)}(2)(μ(3),η(3:1:1)‐P(4)){M(CO)(5)}] (3 a,b) and [{Cp*Cr(CO)(2)}(2)‐(μ(4),η(3:1:1:1)‐P(4)){M(CO)(5)}(2)] (4 a,b) which contain a folded cyclo‐P(4) unit. …”
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“…The hydrolysates were further separated by sequential ultrafiltration to 5 hydrolysate fractions named F1 to F5 from low molecular weight (MW) (<1 kDa) to high MW range (>10 kDa), which were further characterized for TPC, free radical scavenging capacity against DPPH and ABTS, and metal chelating activity. The fraction F4 produced by papain (CH-P4), F1 produced by ficin (CH-F1), and F3 produced by bromelain (CH-B3) showed the strongest antioxidant activity and yield, respectively. …”
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“…LTD induced by 5-HT was blocked by the 5-HT(2) receptor antagonist ketanserin, an NMDA receptor antagonist and by intracellular Ca(2+) chelation. The 5-HT(2) receptor agonist α-me-5-HT mimicked the LTD induced by 5-HT. …”
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“…Herein, we present the activity profiles of the Cu(II), Mn(II) and Ag(I) tdda-phen chelate complexes {[Cu(3,6,9-tdda)(phen)(2)]·3H(2)O·EtOH}(n) (Cu-tdda-phen), {[Mn(3,6,9-tdda)(phen)(2)]·3H(2)O·EtOH}(n) (Mn-tdda-phen) and [Ag(2)(3,6,9-tdda)(phen)(4)]·EtOH (Ag-tdda-phen) (tddaH(2) = 3,6,9-trioxaundecanedioic acid; phen = 1,10-phenanthroline) towards clinical isolates of P. aeruginosa derived from Irish CF patients in comparison to two reference laboratory strains (ATCC 27853 and PAO1). …”
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“…Firstly, we prepared amphiphilic glycol chitosan-5β-cholanic acid conjugates that can self-assemble to form stable nanoparticles with an average of 283.7 ± 5.3 nm. …”
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“…Mouse C2C12 skeletal muscle cells were treated with insulin (10 nM), zinc (20 µM), and the zinc chelator TPEN (various concentrations) over 60 min. …”
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“…Collectively, these data suggest that GBS zinc transport machinery is important for combatting zinc chelation by calprotectin and establishing invasive disease.…”
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“…In order to determine the effects of microglial HO-1-dependent iron overload, aged WT mice were treated with the iron chelator deferoxamine (DFX). DFX caused major improvements in iron, inflammatory and behavioral alterations found in aged mice exposed to LPS. …”
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“…This report includes sections on (1) background on how iron functions in comparative species and how Iron Overload Disorder appears to work in black rhinos, (2) practical recommendations for known diagnostics, (3) a brief review of current investigations on inflammatory and other potential biomarkers, (4) nutrition knowledge and advice as prevention, and (5) an overview of treatment options including information on chelation and details on performing large volume voluntary phlebotomy. …”
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“…Co-incubation with a Ca(2+) blocker nifedipine (5 µM) or a chelator (ethylene glycol-bis (β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid (EGTA), 5 mM) did not alter H(2)S-potentiated BK(Ca) currents and open probability. …”
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“…Finally, we describe the potential for a novel concept of creating ecosystems over asbestos landfills (‘activated landfills’) that utilize nature’s chelating ability to degrade this toxic product effectively.…”
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“…Overall, CT leaves (CTLP) had higher total phenolic content than CTFP (p<0.05). 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of CTFP was higher than that of CTLP (p<0.05), which showed higher iron chelating ability and reducing power than CTFP (p<0.05). …”
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“…While radical-scavenging, inhibition of APs or NO-synthesis, and iron chelation had no effect on the staining pattern, exposure to the complex-I inhibitor, rotenone, prevented interneuronal DCF accumulation. …”
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“…2,2′-Dihydroxybenzophenone-S-methyl-thiosemicarbazone and 3-methoxy-salicylaldehyde were reacted in the presence of oxovanadium(IV) or nickel(II) ions to yield the N(2)O(2)-type-chelate complex. The synthesized complexes were characterized by employing elemental analysis, electronic and infrared spectra, (1)H NMR spectra, magnetic measurements, and thermogravimetric analyses. …”
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“…Further, we revealed that 5-caffeoylquinic acid inhibited melanogenesis by chelating a copper cation from a copper–tyrosinase complex. …”
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“…The upregulation of both terpene synthase and cytochrome P450 genes on cedar media suggests the potential importance of these gene products in the production of secondary metabolites associated with the chelator-mediated Fenton reaction. These results provide new insights into the inherent wood degradation mechanism of G. trabeum and the diversity of brown rot mechanisms.…”
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“…We also present and discuss the latest lines of research related to targeting iron, or its regulatory pathways, as potential promising anticancer strategies for human therapy. Iron chelators, such as deferoxamine or iron-oxide-based nanoparticles, which are already tested in clinical trials, alone or in combination with chemotherapy, are also reported.…”
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“…Sodium thiosulfate (STS) was proposed based on experience with it as a chelating agent to treat calciphylaxis. Previous pilot studies with small sample sizes have suggested its efficacy in the reduction of CaHA volume and nodule formation. …”
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