“…DISCUSSION AND CONCLUSIONS: EFSE showed significant potential for chelation. Its use for the treatment of GAG accumulation could be suggested and generalized to a larger study population.…”
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“…The peripheral N/O chelating of Schiff base ligands, inner bridges, counterions, and metal centers gave rise to a brucite disk cluster [Zn(7)L(6)(OCH(3))(6)](NO(3))(2) (Zn(7), (HL = 2-methoxy-6-((methylimino)-methyl)phenolate)) which crystallized into hexagonal prismatic plates. …”
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“…Finally, other potential treatments such as chelation therapies, use of cholesteryl transfer protein (CETP) inhibitors, lipase inhibitors, fatty acid inhibitors and other treatments are highlighted, which with additional research and appropriate clinical trials, could prove useful in the treatment and management of thrombotic disease through amelioration of plasma Zn(2+) dysregulation in high-risk individuals.…”
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“…In this study, targeting properties of an Affibody-based probe, AC12, containing a -GGGC amino acid sequence as a chelator (designated as AC12-GGGC) labelled with technetium-99m ((99m)Tc) were evaluated for imaging of B7-H3-expressing tumours. …”
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“…Patients affected by the most severe transfusion‐dependent form of the disease (TDT) require lifelong blood transfusions and iron chelation therapy, a symptomatic treatment associated with several complications. …”
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“…Bile significantly affected the growth of the isolates, and the addition of iron chelator extended the lag phase of the sensitive isolate. …”
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“…A total of 42 male, growing pigs (31.08 ± 1.82 kg) were randomly assigned to seven treatments consisting of one negative control (0 mg/kg of added Cu level) and treatments with copper sulfate (CuSO4), Cu-amino acid complex (CuAA), and Cu-hydroxy-4-methylthio butanoate chelate complex (CuHMB) at 50 and 100 mg/kg each for 28 d. …”
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“…The carboxylic acid group of fluoroquinolones is essential to the mode of action but is also responsible for many of its side effects and metal-chelating properties. The synthesis, stability in biological media, and antibacterial activity were evaluated, the latter not only against Mycobacterium tuberculosis but also against other clinically relevant bacterial species, since the parent compounds display a broad spectrum of activity. …”
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“…We found that the BA chelator cholestyramine impaired the antidepressant effects of CSS, which was partially rescued by dietary cholic acid. …”
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“…For TGiA, PCa cells stained by a biocompatible europium chelate antibody-conjugated probe were quantitated by automated time-gated microscopy (OSAM). …”
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“…Moreover, we observed that the metal ions chelator and the antioxidant could block their antibacterial activity. …”
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“…Moreover, NH(4)(+)-induced enhanced activity of glutamate receptors in acute OB slices caused cell death, which was prevented by antagonizing glutamate receptors or chelating intracellular calcium levels. Our study demonstrates that the enhancement of the activity and recruitment of glutamate receptor directly induces neuronal excitotoxicity, and contributes to the vulnerability of OB to acute hyperammonemia, thus providing a potential pathological mechanism of olfactory defects in patients with hyperammonemia and HE.…”
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“…Patch-clamp recordings showed an increase in the frequency of miniature excitatory postsynaptic currents (EPSCs) that was totally occluded by exogenous Ca(2+) chelators and associated with a constitutive increase in resting terminal Ca(2+) concentrations. …”
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“…Importantly, the specific FL enhancement by Al(III) via a chelation-enhanced fluorescence mechanism can be utilized for selective and quantitative determination of Al(III). …”
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“…We propose that in the calcium-selective variants, a calcium ion chelated between Domain II selectivity-filter glutamate and aspartate is knocked-out by the incoming calcium ion in the process of calcium permeation, whereas sodium ions are repelled. …”
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“…Moreover, the interaction of the EGCG–Fe(III) complex was dominated by chelation and electrostatic interaction, while that of the EGCG–In(III) complex was controlled by electrostatic interactions and aromatic ring stacking effects. …”
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“…The ethanol and the hydroethanolic extracts had the highest capacity to scavenge free radicals, to chelate iron and copper and to inhibit lipid peroxidation. …”
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“…CONCLUSION: Clinically, amlodipine therapy is an efficacious adjuvant treatment with conventional iron chelators for improving the levels of MDA and TAC in patients with TDT.…”
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“…In-vitro studies utilized EDTA in various complexes to evaluate cellular viability, including proliferation and toxicity, intracellular enzyme kinetics, and intercellular interactions such as chelation and cellular aggregation. In-vivo studies predominantly utilized the versatile nature of EDTA as a tracer for imaging studies involved in diagnostics and identifying recurrent tumor growth and localization in human patients. …”
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“…Retentates treated with the chelator deferoxamine (DFO) yielded a peak that comigrated with the Fe–DFO complex and originated from iron that adhered to the column in the absence of DFO. …”
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