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  1. 13221
    “…In this study, we have successfully synthesized a novel rhodatetraborane dihydride, [Rh(η(2)-B(3)H(8))(H)(2)(PPh(3))(2)] (1), which represents a Rh(III) complex featuring a bidentate chelate ligand fasormed by B(3)H(8)(−). Extensive characterization of this rhodatetraborane complex has been performed using NMR spectroscopy in solution and X-ray diffraction analysis in the solid state. …”
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    The Synthesis, Characterization, and Fluxional Behavior of a Hydridorhodatetraborane
  2. 13222
    “…PROCEDURES: TGFβ-targeting inhibitory peptide P144 with stable activity was prepared through peptide synthesis and screening, and P144 was coupled with biological chelator DOTA and labeled with radionuclide [(68)Ga] to achieve a stable TGFβ-targeting tracer [(68)Ga]Ga-P144. …”
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    PET imaging with [(68)Ga]-labeled TGFβ-targeting peptide in a mouse PANC-1 tumor model
  3. 13223
    “…Thus, we explore various public health interventions such as hydroxyurea therapy, pneumococcal vaccination, penicillin therapy, iron chelation therapy, and clinical decision support tools that have been implemented in primary healthcare settings and shown to be effective in improving SCD care. …”
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    The Effectiveness of Common Interventions in the Management of Sickle Cell Disease in Primary Care Settings: A Review
  4. 13224
    “…OBJECTIVE: Respiratory functions in thalassemia major (TM) patients concerning poor chelation are a frequently researched issue. Our study aims to evaluate the lung functions of our patients with TM in the chronic transfusion program and to correlate them with their age, ferritin levels, and pre-transfusion hemoglobin values. …”
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    Restrictive effects of thalassemia on respiratory functions: One center experience
  5. 13225
    “…EMP100 is a cyclic oligopeptide bound to a DOTA chelator, with nanomolar affinity for c-MET. The aim of this project was to develop an automated method for radiolabelling the radiopharmaceutical [(68)Ga]Ga-EMP100. …”
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    Fully automated radiolabeling of [(68)Ga]Ga-EMP100 targeting c-MET for PET-CT clinical imaging
  6. 13226
    “…Dynamic light scattering, circular dichroism, and a competition chelator assay were used to compare the Zn(2+) affinity and the effects of ion binding on mS100A7 versus hS100A7. …”
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    Comparative analysis of the physical properties of murine and human S100A7: Insight into why zinc piracy is mediated by human but not murine S100A7
  7. 13227
    “…BACKGROUND: Multifunctional thiosemicarbazones (TSCs) able to bind sigma receptors and chelate metals are considered as a promising avenue for the treatment of pancreatic cancer due to the encouraging results obtained on in vitro and in vivo models. …”
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    Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells
  8. 13228
    “…Calcium antagonists Verapamil, BAPTA-AM and W-7 were used to block calcium channels in the membrane, to chelate intracellular calcium or to inhibit the calmodulin signaling pathways, respectively. …”
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    Ultrafine particles cause cytoskeletal dysfunctions in macrophages: role of intracellular calcium
  9. 13229
    “…We previously reported that S100A8/A9 induces apoptosis of EL-4 lymphoma cells via the uptake of extracellular zinc in a manner similar to DTPA, a membrane-impermeable zinc chelator. In this study, S100A8/A9-induced apoptosis was examined in several cell lines that are weakly sensitive to DTPA, suggesting S100A8/A9 is directly responsible for apoptosis in these cells. …”
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    Regulation of S100A8/A9 (Calprotectin) Binding to Tumor Cells by Zinc Ion and Its Implication for Apoptosis-Inducing Activity
  10. 13230
    por Iyer, Lakshminarayan M, Aravind, L
    Publicado 2002
    “…Based on the conservation of catalytic residues, we predict that CYTH domains are likely to chelate two divalent cations, and exhibit a reaction mechanism that is dependent on two metal ions, analogous to nucleotide cyclases, polymerases and certain phosphoesterases. …”
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    The catalytic domains of thiamine triphosphatase and CyaB-like adenylyl cyclase define a novel superfamily of domains that bind organic phosphates
  11. 13231
    por Shi, X, Dalal, N, Kasprzak, K S
    Publicado 1994
    “…Incubation of sulfite with Ni(II) in the presence of chelators such as tetraglycine, histidine, beta-alanyl-3-methyl-L-histidine (anserine), beta--L-histidine (carnosine), gamma-aminobutyryl-L-histidine (homocarnosine), glutathione, and penicillamine did not have any significant effect on that enhancement. …”
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    Enhanced generation of hydroxyl radical and sulfur trioxide anion radical from oxidation of sodium sulfite, nickel(II) sulfite, and nickel subsulfide in the presence of nickel(II) complexes.
  12. 13232
    “…Tropolone was used as chelating agent in all the extraction methods. Certified values are given for TBT 44±3 μg kg(−1) as Sn, DBT 51 ± 2 μg kg(−1) as Sn, MBT 67 ± 3 μg kg(−1) as Sn, TPhT 6.9 ± 1.2 μg kg(−1) as Sn, and DPhT 3.4 ± 1.2 μg kg(−1) as Sn. …”
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    Certification of butyltins and phenyltins in marine sediment certified reference material by species-specific isotope-dilution mass spectrometric analysis using synthesized (118)Sn-enriched organotin compounds
  13. 13233
    “…It is advisable for pregnant women to avoid occupational or avocational lead exposure that would result in blood lead concentrations > 5 μg/dL. Chelation may have an adjunctive role in the medical management of highly exposed adults with symptomatic lead intoxication but is not recommended for asymptomatic individuals with low blood lead concentrations.…”
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    Recommendations for Medical Management of Adult Lead Exposure
  14. 13234
    “…METHODOLOGY AND PRINCIPAL FINDINGS: The (86)Y-CNT construct was synthesized from amine-functionalized, water-soluble CNT by covalently attaching multiple copies of DOTA chelates and then radiolabeling with the positron-emitting metal-ion, yttrium-86. …”
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    PET Imaging of Soluble Yttrium-86-Labeled Carbon Nanotubes in Mice
  15. 13235
    Publicado 1988
    “…An analysis of the solubility properties of ZO-1 from suspension cells and monolayers revealed that high salt, nonionic detergent, and a buffer containing chelators were somewhat more effective at solubilizing ZO-1 from suspension cells than from monolayers.…”
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    Localization of the tight junction protein, ZO-1, is modulated by extracellular calcium and cell-cell contact in Madin-Darby canine kidney epithelial cells
  16. 13236
    por Drummond, GS, Kappas, A
    Publicado 1981
    “…Desferoxamine also did not block heme oxygenase induction by antimony, but this chelator did prevent the rebound increase in ALAS activity associated with antimony or cobalt treatment. …”
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    Potent heme-degrading action of antimony and antimony-containing parasiticidal agents
  17. 13237
    Publicado 1994
    “…Conversely, addition of the iron chelator desferrioxamine (100 microM) at the time of stimulation with IFN- gamma/LPS increases NOS activity up to 2.5-fold in J774 cells. …”
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    Iron regulates nitric oxide synthase activity by controlling nuclear transcription
  18. 13238
    “…Intracellular free-calcium concentration ([Ca(2+)](i)) increased transiently during hyposmotic swelling (peak at ∼30 s, return to baseline within ∼90 s), but chelation of cell Ca(2+) did not prevent the membrane hyperpolarization elicited by the hyposmotic solution. …”
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    Cell Swelling Activates the K(+) Conductance and Inhibits the Cl(−) Conductance of the Basolateral Membrane of Cells from a Leaky Epithelium
  19. 13239
    “…Exposure of cells to the Ca(2+) chelator BAPTA had no effect on nucleotide- or fMLP-induced ERK phosphorylation. …”
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    Signaling pathways downstream of P2 receptors in human neutrophils
  20. 13240
    “…RESULTS: In patients with baseline LIC ≥7 mg Fe/g dry weight, deferasirox initiated at 20 or 30 mg/kg/d produced statistically significant decreases in LIC (P < 0.001); these decreases were greatest in MDS and least in DBA. As chelation efficiency and iron excretion did not differ significantly between disease groups, the differences in LIC changes are consistent with mean transfusional iron intake (least in MDS: 0.28 ± 0.14 mg/kg/d; greatest in DBA: 0.4 ± 0.11 mg/kg/d). …”
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    Relative response of patients with myelodysplastic syndromes and other transfusion-dependent anaemias to deferasirox (ICL670): a 1-yr prospective study
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