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  1. 13281
    por Madke, Bhushan, Khopkar, Uday
    Publicado 2011
    “…The administration of a gadolinium chelate contrast agent has been reported to induce the development of NSF, particularly in patients who have acute or chronic renal disease with a glomerular filtration rate (GFR) lower than 30-mL/min/1.73 m(2) and in those with acute renal insufficiency. …”
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    Nephrogenic systemic fibrosis
  2. 13282
    “…Here, the dimerization of the pharmacophore Glu‐ureido‐Lys via the (68)Ga chelator N,N′-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N′-diacetic acid (HBED-CC) was investigated to further improve the binding characteristics and pharmacokinetics. …”
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    A dimerized urea-based inhibitor of the prostate-specific membrane antigen for (68)Ga-PET imaging of prostate cancer
  3. 13283
    “…Hyperglycemic and age-matched control mice were treated with and without Zn chelator, N,N,N′,N′-tetrakis (2-pyridylemethyl) ethylenediamine (TPEN), at 5 mg/kg body-weight daily for 4 months. …”
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    Diabetes-Induced Hepatic Pathogenic Damage, Inflammation, Oxidative Stress, and Insulin Resistance Was Exacerbated in Zinc Deficient Mouse Model
  4. 13284
    por Meghashri, S., Gopal, S.
    Publicado 2012
    “…MATERIALS AND METHODS: PE of N. arbortristis leaves was investigated for antioxidant activity employing various established in vitro systems, such as lipid peroxidation in liposome, DPPH and hydroxyl radical scavenging, reducing power assay, and iron ion chelation. Identification of active constituent in PE of N. arbortristis responsible for antioxidant activity by HPLC. …”
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    Biochemical characterization of radical scavenging polyphenols from Nyctanthes arbortristis
  5. 13285
    por Ishima, T, Iyo, M, Hashimoto, K
    Publicado 2012
    “…Specific inhibitors of inositol 1,4,5-triphosphate (IP(3)) receptors and BAPTA-AM, a chelator of intracellular Ca(2+), blocked the effects of aripiprazole. …”
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    Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripiprazole
  6. 13286
    “…These findings indicate that ceftriaxone plus sulbactam with VRP1034 acts as a potent free radical scavenger and exhibits metal chelating properties that reduce free radical mediated tissue injury and prevent dysfunction of hepatic and renal organs during metal intoxication.…”
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    Protective role of ceftriaxone plus sulbactam with VRP1034 on oxidative stress, hematological and enzymatic parameters in cadmium toxicity induced rat model
  7. 13287
    “…Silencing of c-FLIP(S), but not c-FLIP-long (c-FLIP(L)), resulted in a remarkable increase in apoptosis and significant reduction of clonogenic survival. Furthermore, chelation of intracellular Ca(2+) or inhibition of calmodulin caused a rapid proteasomal degradation of c-FLIP(S), a significant increase of the two-step processing of procaspase-8, and reduced clonogenicity in response to TRAIL. …”
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    Upregulation of c-FLIP-short in response to TRAIL promotes survival of NSCLC cells, which could be suppressed by inhibition of Ca(2+)/calmodulin signaling
  8. 13288
    “…By using a quick purification protocol, based on recovery of periplasmic space content and metal-chelating chromatography, the recombinant α-synuclein protein forms could be purified in a single step to ≥ 95% purity. …”
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    One single method to produce native and Tat-fused recombinant human α-synuclein in Escherichia coli
  9. 13289
    por Alpert, Michael H., Alford, Simon
    Publicado 2013
    “…Furthermore, repetitive oscillations are prevented by fast, but not slow, Ca(2+) chelation. Taken together, these results demonstrate that K(Ca)2 channels are closely located to NMDA receptor-dependent Ca(2+) entry. …”
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    Synaptic NMDA Receptor-Dependent Ca(2+) Entry Drives Membrane Potential and Ca(2+) Oscillations in Spinal Ventral Horn Neurons
  10. 13290
    “…The common coordination modes, chelating (via the amino N and the carboxyl­ate O atoms) and bridging (via the carboxyl­ate O atom), are exhibited by the tyrosinates. …”
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    μ(3)-Methoxido-κ(3) O:O:O-tris­(μ-l-p-tyrosinato-κ(3) N,O:O)tris­(l-p-tyrosinato-κ(2) N,O)trinickel(II,III) methanol tetra­solvate
  11. 13291
    “…Furthermore, addition of the calcium chelator, EGTA, or exposure of cells to the non-selective Ca(2+) channel blocker, NiCl(2), significantly attenuated the PACAP-evoked [Ca(2+)](i) increase. …”
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    Activation of PAC1 Receptors in Rat Cerebellar Granule Cells Stimulates Both Calcium Mobilization from Intracellular Stores and Calcium Influx through N-Type Calcium Channels
  12. 13292
    “…In the present study, we aimed to further increase the iron concentration in rice seeds without increasing the sensitivity to iron deficiency by enhancing the uptake and transport of iron via a ferric iron chelator, mugineic acid. To this end, we introduced the soybean ferritin gene (SoyferH2) driven by two endosperm-specific promoters, along with the barley nicotianamine synthase gene (HvNAS1), two nicotianamine aminotransferase genes (HvNAAT-A and -B), and a mugineic acid synthase gene (IDS3) to enhance mugineic acid production in rice plants. …”
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    Iron-biofortification in rice by the introduction of three barley genes participated in mugineic acid biosynthesis with soybean ferritin gene
  13. 13293
    “…EDTA (0.3mg/ml) significantly inhibited biofilm formation in both C. albicans and non-albicans isolates (P=0.0001) presumably due to chelation of necessary metal cations for the process-completion. …”
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    Heparin-benzyl alcohol enhancement of biofilms formation and antifungal susceptibility of vaginal Candida species isolated from pregnant and nonpregnant Saudi women
  14. 13294
    “…The decrease in CX3CL1 expression by ET-1 was inhibited by cycloheximide, Ca(2+) chelation and staurosporine. CONCLUSION: These findings suggest that ETs are one of the factors regulating astrocytic chemokine production. …”
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    Different actions of endothelin-1 on chemokine production in rat cultured astrocytes: reduction of CX3CL1/fractalkine and an increase in CCL2/MCP-1 and CXCL1/CINC-1
  15. 13295
    “…LPA-mediated BK(Ca) channel activation was also attenuated by the PLC inhibitor U-73122, IP(3) inhibitor 2-APB, Ca(2+) chelator BAPTA, or PKC inhibitor calphostin. In addition, mutations in RCK1 and RCK2 also attenuated LPA-mediated BK(Ca) channel activation. …”
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    Activation of Lysophosphatidic Acid Receptor Is Coupled to Enhancement of Ca(2+)-Activated Potassium Channel Currents
  16. 13296
    “…Furthermore, many candidate genes, which were involved in defense and detoxification mechanisms including signaling protein kinases, transcription factors, metal transporters and chelate compound biosynthesis related enzymes, were successfully identified in response to heavy metal Pb. …”
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    Transcriptome Profiling of Radish (Raphanus sativus L.) Root and Identification of Genes Involved in Response to Lead (Pb) Stress with Next Generation Sequencing
  17. 13297
    “…These studies reveal potential polypharmacology of organometallic Ir(III) complexes, with MoA and cell selectivity governed by structural changes in the chelating ligands.…”
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    Organometallic Iridium(III) Anticancer Complexes with New Mechanisms of Action: NCI-60 Screening, Mitochondrial Targeting, and Apoptosis
  18. 13298
    “…RIT has been in use for more than 20 years and has progressed significantly with the discovery of new molecular targets, the development of new stable chelates, the humanization of monoclonal antibodies (MAbs), and the use of pretargeting techniques. …”
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    Radioimmunotherapy of B-Cell Non-Hodgkin’s Lymphoma
  19. 13299
    “…Several front-line chemotherapeutics cause mitochondria-derived, oxidative stress-mediated cardiotoxicity. Iron chelators and other antioxidants have not completely succeeded in mitigating this effect. …”
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    Mito-Tempol and Dexrazoxane Exhibit Cardioprotective and Chemotherapeutic Effects through Specific Protein Oxidation and Autophagy in a Syngeneic Breast Tumor Preclinical Model
  20. 13300
    “…Erk activation required little Ca(2+) release and was blocked by PLCβ or PKC inhibition but not by intracellular Ca(2+) chelation, suggesting Ca(2+) independent activation of novel PKC isoforms. …”
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    Stimulation of α(1a) Adrenergic Receptors Induces Cellular Proliferation or Antiproliferative Hypertrophy Dependent Solely on Agonist Concentration
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