“…One of the two compounds bears structural resemblance to iron chelators and the other strongly activates the MAPK pathways. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Siderophores are low-molecular-weight, iron-chelating compounds that are secreted for iron uptake; thus, the loss of siderophore-synthesis genes indicates that these strains have adapted to environments with high-iron concentrations. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The results were related to the firmness of fruits, galacturonic acid content in water, chelator, sodium carbonate and insoluble pectin fractions, polygalacturonase and pectin methylesterase activities. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We also found that Aβ(1-40) (but not Aβ(1-42)) causes a hypercontractile phenotype in transformed rat cerebral VSMC that likely results from a HSPG-mediated augmentation in intracellular Ca(2+) activity, as both Aβ(1-40)-induced VSMC hypercontractility and increased Ca(2+) influx are inhibited by pharmacological HSPG depletion. Moreover, chelation of extracellular Ca(2+) with ethylene glycol tetraacetic acid (EGTA) does not prevent the production of Aβ(1-40)- or Aβ(1-42)-mediated reactive oxygen species (ROS), suggesting that Aβ-induced ROS and VSMC hypercontractility occur through different molecular pathways. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The current treatment for SLC25A38 congenital sideroblastic anemia is chronic blood transfusion coupled with iron chelation. The function of SLC25A38 is not known. Here we report that the SLC25A38 protein, and its yeast homolog Hem25, are mitochondrial glycine transporters required for the initiation of heme synthesis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: Here, we investigate Nrf2 induction by the metal chelator and known nuclear factor-κB inhibitor pyrrolidine dithiocarbamate (PDTC) in cultured astrocytes and neurons, and mouse brain. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To this end, an animal product-free chemically defined cryopreservation medium was formulated by adding two antioxidants (reduced glutathione and ascorbic acid 2-phosphate), two polymers (PVA and ficoll), two permeating cryoprotectants (ethylene glycol and dimethylsulfoxide), a disaccharide (trehalose), and a calcium chelator (EGTA) to HEPES-buffered DMEM/F12. To limit the number of experimental groups, the concentration of trehalose, both polymers, and EGTA was fixed while the presence of the permeating CPAs and antioxidants was varied. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These effects were canceled by the addition of the iron chelator, deferoxamine. After UV irradiation, the expression of phosphorylated Akt (pAkt) was decreased in LCN2-silenced cells, and the PI3K inhibitor canceled the difference induced in UV sensitivity by LCN2. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here, we show that rotenone elevates intracellular free calcium ion ([Ca(2+)](i)) level, and activates CaMKII, resulting in inhibition of mTOR signaling and induction of neuronal apoptosis. Chelating [Ca(2+)](i) with BAPTA/AM, preventing extracellular Ca(2+) influx using EGTA, inhibiting CaMKII with KN93, or silencing CaMKII significantly attenuated rotenone-induced H(2)O(2) production, mTOR inhibition, and cell death. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The macrocyclic cyclam moieties adopt the trans-III conformation with six- and five-membered chelate rings in chair and gauche conformations. The [ZnCl(4)](2−) anions have a slightly distorted tetra­hedral shape. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: Seven CD patients (mean age 38 (19–75), 3 male)) undergoing ileal resection underwent 3T MR enterography including axial ultrafast spoiled gradient-echo T1 post IV gadolinium chelate. Regions of interest were placed in bowel destined for resection and registered to trans-mural histological sections (n = 28 across 7 bowel sections) via MRI of the resected specimen. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The total phenolic, flavone and flavonol, and flavanone and dihydroflavonol contents were determined by Folin–Ciocalteau, aluminum chloride and 2,4-dinitrophenylhydrazine colorimetric methods, respectively. The metal ion chelating activity, acetylcholinesterase inhibition capacity, and free radical scavenging potential of the extracts towards ABTS (2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid), DPPH (2,2-diphenyl-1-picrylhydrazyl), hydroxyl, superoxide and nitric oxide were also evaluated. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The stem methanol extract showed the highest amount of both phenolic (273.51 ± 4.84 mg gallic acid/g extract) and flavonoid contents (163.41 ± 4.62 mg catechin/g extract) and strong DPPH(•) radical scavenging (IC(50) = 27.81 μg/mL) and metal chelation activity (IC(50) = 80.20 μg/mL). The stem aqueous extract showed the highest ABTS(•+) scavenging ability. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Whereas plasma and intraerythrocytic Ca(2+) cannot be accurately measured in the presence of chelators such as citrate and EDTA, the majority of Ca(2+)-dependent parameters are stabilized in CPDA samples. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This redox-mediated T-type Ca(2+) channel inhibition operated through the modulation of Ca(V)3.2 channel sensitivity to ambient zinc, as it can be prevented or reversed by zinc chelation and mimicked by exogenous zinc. Elimination of the zinc-binding site in Ca(V)3.2 rendered the channel insensitive to SP-mediated inhibition. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Other variables assessed included sex, age, method of chelator therapy, and mean hemoglobin and ferritin levels for the past 2 years. …”
Enlace del recurso
Enlace del recurso

“…In this study, we investigated the role of deferoxamine (DFO), a clinically used iron chelator, in a mouse model of surgery-induced cognitive dysfunction and assessed its neuroprotective effects on neuroinflammation, oxidative stress, and memory function. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…For this, the necrosis avid NIRF cyanine HQ4 was radiolabeled with (111)indium, via the chelate diethylene triamine pentaacetic acid (DTPA). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Besides neutrophils from a control culture, we also analyzed neutrophils stimulated for 1–2 h with phorbol myristate acetate (PMA), a substance inducing the formation of so-called Neutrophil Extracellular Traps (or NETs), a defense system again pathogens possibly involving proteins with metal chelating properties. In order to gain insight in metal transport during this process, precise local evaluation of elemental content was performed reaching limits of detection (LODs) of 1 ppb. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The phenotype positive strains of MBL genes were screened using the Kirby-Bauer diffusion method by adding metal ion-chelating agent EDTA on the imipenem susceptibility paper. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso