“…Background: Neuromelanin is a pigment with strong iron‐chelating properties preferentially found in dopaminergic neurons of the substantia nigra pars compacta (SNpc). …”
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“…No impact of the polyether chain on the chelation properties was observed, while significantly lower anti-proliferative effects were observed than for deferoxamine. …”
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“…Inhibition by GTSM was reduced by addition of the cell-impermeant Cu chelator, bathocuproine disulfonate (BCS). Neocuproine exhibited Cu-dependent growth inhibition of all organisms. …”
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“…N. gonorrhoeae produces eight known TdTs, of which four are utilized for acquisition of iron or iron chelates from host-derived proteins or xenosiderophores produced by other bacteria. …”
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“…They comprise the α-emitter (227)Th complexed to a 3,2-hydroxypyridinone chelator conjugated to a tumor-targeting monoclonal antibody. …”
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“…He is doing well on chelation therapy. Fifteen years later, a second‐degree sibling (female, 16 years) presented with fulminant WD and underwent OLT. …”
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“…CLIC1 knockdown greatly increased basal ROS levels, an effect prevented by BAPTA-AM, an intracellular calcium chelator. Intracellular Ca(2+) measurements clearly showed that CLIC1 knockdown significantly increased chelerythrine-induced Ca(2+) signaling as well as the basal Ca(2+) level in A549 cells compared to these levels in control cells. …”
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“…The currently available treatment for TDT is lifelong transfusions and iron chelation therapy or allogenic bone marrow transplantation as a curative option. …”
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“…The coordinated macrocyclic ligand in (I) adopts the most energetically favourable trans-III conformation with an equatorial orientation of the substituent at the protonated distal 3-position N atom in a six-membered chelate ring. The coordination of the carb­oxy­lic acid group of the cation to a neighbouring com­plex unit results in the formation of infinite chains running along the b-axis direction, which are cross­linked by N—H⋯O hydrogen bonds between the secondary amine groups of the macrocycle and O atoms of the per­chlorate counter-anions to form sheets lying parallel to the (001) plane. …”
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“…NP were labeled by directly using (68)Ga(3+) eluted in HCL 0.05 N, from hospital suited (68)Ge/(68)Ga generator and in absence of chelator. The first kit type approach involved the application of (68)Ga(3+) as an ionotropic gelation agent for in-situ forming NP. …”
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“…In contrast, in control slices Fe-NTA did not affect LTP but decreased significantly the AMPAR fEPSP. Meanwhile, iron chelation with deferiprone decreased AMPAR transmission in PAE and control slices and decreased LTP only in controls slices. …”
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“…The specificity of the fluorescence signal was confirmed upon treatment with TPEN, a high-affinity zinc chelator. Multiple sequence alignment and phylogenetic analyses showed that TMEM163 is related to distinct members of the cation diffusion facilitator (CDF) protein family. …”
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“…Antioxidant profile of usnic acid determined by eight distinguishes bioanalytical antioxidant methods including 1,1-diphenyl-2-picrylhydrazyl (DPPH·), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS(•)(+)), superoxide anion radical (O(2)(•)(−)) and N,N-dimethyl-p-phenylenediamine (DMPD(•)(+)) scavenging activities, cupric ion (Cu(2+)), ferric ion (Fe(3+)) and Fe(3+)-TPTZ reducing abilities and ferrous ion (Fe(3+)) chelating activity. Usnic acid was found as potent DPPH· (IC(50): 49.50 μg/mL), DMPD(•)(+) (IC(50): 33.00 μg/mL), O(2)(•)(−) (IC(50): 18.68 μg/mL), and ABTS(•)(+) (IC(50): 10.41 μg/mL) scavenging effects. …”
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“…In these complexes, phen binds via a N,N′-chelate pocket, while the monoanionic dcf—ligand remains either uncoordinated (in the case of 1 and 3) or coordinated in a bidentate fashion (in the case of 2). …”
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“…Sperm survival was determined within hours as the ability of spermatozoa to maintain progressive motility (PM) during the storage of ejaculate diluted with lactose-chelate-citrate-yolk (LCCY) medium at +4 °C. Strong positive correlation between PR and thawed sperm motility (r = 0.90, p < 0.05) as well as between PR and sperm survival (r = 084, p < 0.05) was revealed. …”
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“…CONCLUSIONS: Taken together, the results of our study indicate that H(2) regulated the expression of genes relevant to sulfur and glutathione metabolism and enhanced glutathione metabolism which resulted in Cd tolerance by activating antioxidation and Cd chelation. These results may help to elucidate the mechanism governing H(2)-induced Cd tolerance in alfalfa.…”
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“…However, the image quality is not satisfying after intravenous injection of gadolinium chelate (GdC), and occasional failure in GdC uptake has been noticed after traditional intratympanic injection. …”
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“…GEF-mediated HFDPC proliferation was blocked by the LPA receptor antagonist and Ca(2+) chelator. HFDPC treatment with GEF stimulated vascular endothelial growth factor release. …”
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“…Copper accumulation and toxicity after exposure to either CuO-NPs or CuO-Fe-NPs was prevented in the presence of copper chelators, while neutralization of the lysosomal pH by bafilomycin A1 prevented toxicity without affecting cellular copper accumulation or ROS production. …”
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“…A subsection describing novel all-carbon-based glycoconjugates such as fullerenes and carbon nanotubes is inserted, followed by a promising strategy involving dendrons self-assembling around metal chelates. The chapter then ends with those glycodendrimers that have been prepared using commercially available dendrimers possessing varied functionalities, or systematically synthesized using either divergent or convergent strategies.…”
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