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  1. 13661
    “…The addition of the antioxidant L-methionine and chelating agent disodium EDTA improved the formulation’s long-term colloidal and thermal stability. …”
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    Development and biophysical characterization of a humanized FSH–blocking monoclonal antibody therapeutic formulated at an ultra-high concentration
  2. 13662
    “…The enzyme activity was susceptible to a calcium chelator or reducing agent, suggesting Ca(2+) dependency and disulfide linkage required for the catalytic activities of the secretory type of PLA(2)s. …”
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    Identification of four secretory phospholipase A(2)s in a lepidopteran insect, Acrolepiopsis sapporensis, and their functional association with cellular immune responses
  3. 13663
    “…PROCEDURES: The humanized anti-CEA M5A-IR800 “sidewinder” (M5A-IR800-SW) antibody-dye conjugate was designed with a NIR 800 nm dye incorporated into a PEGylated linker and conjugated with the metal chelate p-SCN-Bn-deferoxamine (DFO) for zirconium-89 PET imaging ((89)Zr, half-life 78.4 h). …”
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    Multimodality PET and Near-Infrared Fluorescence Intraoperative Imaging of CEA-Positive Colorectal Cancer
  4. 13664
    “…In the dark, the ruthenium-chelating peptide had a triple action. First, it prevented other biomolecules from coordinating with the metal center. …”
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    Cyclic Ruthenium-Peptide Conjugates as Integrin-Targeting Phototherapeutic Prodrugs for the Treatment of Brain Tumors
  5. 13665
    “…Our previous study found that the mobile zinc (Zn((2)+)) level increased rapidly after optic nerve injury in the retina, specifically in the vesicles of the inner plexiform layer. Furthermore, chelating Zn((2)+) significantly promoted axonal regeneration with a long-term effect. …”
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    Selective deletion of zinc transporter 3 in amacrine cells promotes retinal ganglion cell survival and optic nerve regeneration after injury
  6. 13666
    “…They also had antioxidant activities and showed satisfactory metal-chelating properties toward Fe(+2), Zn(+2), and Cu(+2), inhibiting oxidative stress in AD brains. …”
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    Modified Tacrine Derivatives as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease: Synthesis, Biological Evaluation, and Molecular Modeling Study
  7. 13667
    “…By comparing the antioxidant capacity of DPPH (1,1-Diphenyl-2-picrylhydrazyl free radical), AB-TS (2,2′-Azinobis-3-ethylbenzthiazoline-6-sulphonate), and iron chelation, it was found that both PP-FSM and P-FSM were superior to FSM, and the antioxidant capacity had a certain correlation with the contents of total phenols and total flavonoids.…”
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    Effects of Polygonatum sibiricum on Physicochemical Properties, Biological Compounds, and Functionality of Fermented Soymilk
  8. 13668
    “…Trace metal analysis and speciation modelling verified EDTA as an effective copper chelator. Toxicity thresholds for P. canaliculus were low, with 10% developmental abnormalities in D-stage larvae being recorded upon exposure to 1.10 μg·L(−1) bioavailable copper for 66 h. …”
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    Metabolic Regulation of Copper Toxicity during Marine Mussel Embryogenesis
  9. 13669
    “…To create 89Zr-DFO-TIGIT, a TIGIT monoclonal antibody was conjugated to the metal chelator DFO and radiolabeled with 89Zr. Following tracer preparation, glioma-bearing mice (GL261 cell line) were injected with 89Zr-DFO-TIGIT allowing for the visualization of TIGIT in the tumor microenvironment. …”
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    NEIM-01 IMMUNOSUPPRESSION IN THE GLIOMA MICROENVIRONMENT: USING PET IMAGING TO HIGHLIGHT THE PRESENCE OF TIGIT
  10. 13670
    “…Genes for iron management encode metal and other transporters, enzymes synthesizing chelators and reducing substances, transcription factors, and several types of regulators. …”
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    Black sheep, dark horses, and colorful dogs: a review on the current state of the Gene Ontology with respect to iron homeostasis in Arabidopsis thaliana
  11. 13671
    “…Overall, our findings support that magnetotactic bacteria could act as self-replicating iron-chelating agents and indicate that they interfere with proliferation and lead to increased apoptosis of cancer cells. …”
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    Magnetospirillum magneticum triggers apoptotic pathways in human breast cancer cells
  12. 13672
    “…Classic supportive management includes sodium bicarbonate, gastrointestinal chelating agents, and vasopressors. Recently, intravenous lipid emulsion (supported by a low evidence level) has also been used. …”
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    Effective Treatment of Acute Tricyclic Antidepressant Poisoning with Cardiogenic Shock and Severe Rhabdomyolysis Using ECMO and CytoSorb(®) Adsorber
  13. 13673
    “…Using an antibody-mediated complement-dependent model of injury directed against rat visceral glomerular epithelial cells (podocytes) and two MPs (FePPIX, CoPPIX) that induce both HO-1 expression and HO enzymatic activity in vivo but differ in their chelated metal, we assessed their efficacy in reducing albuminuria. …”
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    Metalloporphyrins Reduce Proteinuria in Podocyte Immune Injury: The Role of Metal and Porphyrin Moieties
  14. 13674
    “…Methods: We designed a protocol based on agarose beads carrying cation chelates to specifically bind to the 6His-tagged membrane-sensing peptide. …”
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    Proof of concept of using a membrane-sensing peptide for sEVs affinity-based isolation
  15. 13675
    “…Although the relative transcript abundance of genes associated with plastidial Fe uptake and homeostasis decreased towards the inner leaf layers, both ferric chelate reductase FRO7 transcripts and activity were detected in the innermost leaf layer. …”
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    Iron uptake of etioplasts is independent from photosynthesis but applies the reduction-based strategy
  16. 13676
    “…We observe an increase in metal chelators such as calprotectin (CP) and lipocalin-2 during diabetic wound infections compared to nDb. …”
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    The impact of nutritional immunity on Group B streptococcal pathogenesis during wound infection
  17. 13677
    “…In this work, an interaction including the electrostatic forces and chelating forces between lignin and Ag(+) was regulated via carboxymethylation modification. …”
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    Silver Ions Drive Ordered Self-Assembly Mechanisms and Inherent Properties of Lignin Nanoflowers
  18. 13678
    “…Preventing the BG calcium hyperexcitability of SCA1 mice by loading BG with the calcium chelator BAPTA restored sI(AHP) and spontaneous firing rate of PCs to similar levels of wildtype mice. …”
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    Altered calcium signaling in Bergmann glia contributes to spinocerebellar ataxia type-1 in a mouse model of SCA1
  19. 13679
    “…X-ray Photoelectron Spectroscopy (XPS) studies establish optimum OFGs for reduction of Cr(VI) and chelation of the reduced Cr(III). Adsorption and stripping cycles show the oxidized and reduced biochar as better adsorbents with excellent stripping of Cr up to >98 % upon desorption with 1 M NaOH.…”
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    Reduced and oxidized rice straw biochar for hexavalent chromium adsorption: Revisiting the mechanism of adsorption
  20. 13680
    “…The yogurts were subjected to gastric and intestinal digestion, and TEER was recorded. Ferrous ion chelating activity, ferric reducing potential, and DPPH radical scavenging were also examined to determine the yogurts’ antioxidant capacity. …”
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    Influences of Yogurt with Functional Ingredients from Various Sources That Help Treat Leaky Gut on Intestinal Barrier Dysfunction in Caco-2 Cells
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