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  1. 13741
    “…CONCLUSION: Pulmonary hypertension is common in patients with thalassemia intermedia. Irregular chelation therapy or absence of this treatment might lead to diastolic dysfunction, and serum ferritin levels below 1000 ng/ml could be an important factor in preventing the development of diastolic dysfunction or slowing down its progression.…”
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    Prevalence of Pulmonary Hypertension in Patients with Thalassemia Intermedia in 2009: a single center’s experience
  2. 13742
    “…Purification was only possible under native conditions by Nickel-chelate chromatography and subsequent separation by Blue Native PAGE. …”
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    A Putative Non-Canonical Ras-Like GTPase from P. falciparum: Chemical Properties and Characterization of the Protein
  3. 13743
    “…METHODS: C6 was conjugated to the bifunctional chelator NOTA (1, 4, 7-triazacyclononanetriacetic acid) for radiolabeling [(18)F]AlF conjugation. …”
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    Development of a Novel PET Tracer [(18)F]AlF-NOTA-C6 Targeting MMP2 for Tumor Imaging
  4. 13744
    “…The cation metal core consists of six Ni(II) atoms coordinated in a slightly distorted octa­hedral N(2)O(4) configuration by N and O atoms of 12 deprotonated l-alaninate ligands exhibiting both bridging and chelating modes. This metal–organic coordination motif encapsulates one Ce(III) atom that shows an icosa­hedral coordination by the O-donor atoms of the l-alaninate ligands, with Ce—O distances varying in the range 2.455 (5)–2.675 (3) Å. …”
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    Crystal structure of an unknown solvate of dodecakis­(μ(2)-alaninato-1:2κ(2) O:N,O)cerium(III)hexa­nickel(II) aqua­tris­(hydroxido-κO)tris­(nitrato-κ(2) O,O′)cerate(III)
  5. 13745
    “…Moreover, SBF-1 inhibited SERCA activity, depleted ER Ca(2+) and increased cytosolic Ca(2+) levels. 1,2-Bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid, a chelator of Ca(2+), partially blocked SBF-1-induced ER stress and growth inhibition. …”
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    SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2
  6. 13746
    “…Activity was inhibited by sulfhydryl reagents, metal-chelating agents and heavy metal ions. The enzyme utilized both NAD(+) and NADP(+) as coenzymes with K (m) values of 0.74 mM and 40 mM, respectively. …”
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    Purification and Characterization of a Novel NAD(P)(+)-Farnesol Dehydrogenase from Polygonum minus Leaves
  7. 13747
    “…The antioxidant assays showed enhanced potency of extract from ripe orange peel with EC50 values of 2.71 ± 0.03 mg/mL for 2,2-diphenyl-1-picrylhydrazyl (DPPH), 0.67 ± 0.03 mg/mL for hydroxyl radicals (OH*), 0.57 ± 0.02 mg/mL for Fe(2+) chelation, and 0.63 ± 0.06 mg/mL for malondialdehyde (MDA), and was more potent than unripe orange peel.…”
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    HPLC-DAD Phenolic Characterization and Antioxidant Activities of Ripe and Unripe Sweet Orange Peels
  8. 13748
    “…The antioxidant assays showed the enhanced potency of NJE with a half maximal inhibitory concentration (IC(50)) value of 222.22 ± 7.4 μg/mL for 2,2-diphenyl-1-picrylhydrazyl (DPPH), 13.90 ± 0.5 μg/mL for 2,2′-azino-bis(3-ethyl benzothiazoline-6-sulfonic acid) diammonium salt (ABTS), 113.81 ± 4.2 μg/mL for superoxide, 948 ± 21.1 μg/mL for metal chelating and 12.3 ± 0.43 mg FeSO(4) equivalent/g of extract for ferric reducing antioxidant power assays and was more potent than hexane extract. …”
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    Antioxidant, Biomolecule Oxidation Protective Activities of Nardostachys jatamansi DC and Its Phytochemical Analysis by RP-HPLC and GC-MS
  9. 13749
    “…We then purified the protein with a Ni-chelate column that bound the His tag engineered into the C-terminus of the protein followed by an anion exchange column. …”
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    Scalable Production of a Multifunctional Protein (TSG-6) That Aggregates with Itself and the CHO Cells That Synthesize It
  10. 13750
    “…The intracellular Ca(2+) chelator BAPTA-AM significantly prevented the tolerance. …”
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    Brief low [Mg(2+)](o)-induced Ca(2+) spikes inhibit subsequent prolonged exposure-induced excitotoxicity in cultured rat hippocampal neurons
  11. 13751
    “…At that time, she was hypovolemic, hyperkalemic and acidotic, and was eventually treated with sodium bicarbonate and potassium chelation. At the time of the presentation to the NIH, her laboratory evaluation revealed serum potassium 5.1 mmol/l (reference range: 3.4–5.1 mmol/l), aldosterone 2800 ng/dl (reference range: ≤21 ng/dl) and plasma renin activity 90 ng/ml/h (reference range: 0.6–4.3 ng/ml per h). …”
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    Pseudohypoaldosteronism type 1 due to novel variants of SCNN1B gene
  12. 13752
    “…Peptides were coupled to the DOTA chelator through a PEG4 spacer at the N-terminus. Derivatives were characterized for serum stability, binding affinity on PC-3 human prostate cancer cells, biodistribution in tumor-bearing mice, and gamma camera imaging at 1, 6, and 24 h after injection. …”
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    Pre-clinical evaluation of eight DOTA coupled gastrin-releasing peptide receptor (GRP-R) ligands for in vivo targeting of receptor-expressing tumors
  13. 13753
    “…In the present study, an EGFR-binding affibody molecule (ZEGFR:2377) was site-specifically conjugated with a deferoxamine (DFO) chelator and labelled under mild conditions (room temperature and neutral pH) with a positron-emitting radionuclide (89)Zr. …”
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    PET imaging of epidermal growth factor receptor expression in tumours using (89)Zr-labelled ZEGFR:2377 affibody molecules
  14. 13754
    “…The objective of this study was to determine the effects of chromium methionine (Cr-Met) chelate supplementation on blood metabolites and fatty acid profile of beef from Holstein steers during late fattening period. …”
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    Effects of Chromium Methionine Supplementation on Blood Metabolites and Fatty Acid Profile of Beef during Late Fattening Period in Holstein Steers
  15. 13755
    “…[Image: see text] Chelating phosphines are effective additives and supporting ligands for a wide array of iron-catalyzed cross-coupling reactions. …”
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    Electronic Structure and Bonding in Iron(II) and Iron(I) Complexes Bearing Bisphosphine Ligands of Relevance to Iron-Catalyzed C–C Cross-Coupling
  16. 13756
    “…RESULTS: Investigating the influence of calcium on the HtrA-mediated cleavage of recombinant E-cadherin (rCdh1) in vitro, we tested different concentrations of calcium ions and the calcium chelator ethylenediaminetetraacetic acid (EDTA). Calcium efficiently reduced HtrA-mediated E-cadherin fragmentation. …”
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    Calcium binding protects E-cadherin from cleavage by Helicobacter pylori HtrA
  17. 13757
    “…BACKGROUND: The requirements for magnesium (Mg) supplementation increase under regional citrate anticoagulation (RCA) because citrate acts by chelation of bivalent cations within the blood circuit. …”
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    The Effects of High Level Magnesium Dialysis/Substitution Fluid on Magnesium Homeostasis under Regional Citrate Anticoagulation in Critically Ill
  18. 13758
    “…In this study, we evaluated the neutralization activity of a range of liposome formulations in different sizes coated with anti-gp120 llama antibody fragments (Vhhs) conjugated via either non-covalent metal chelation or a covalent linkage. The non-covalent construct demonstrated identical binding affinity to HIV-1 envelope glycoprotein gp120 and neutralizing ability for HIV virus as free Vhh. …”
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    Inhibition of HIV Virus by Neutralizing Vhh Attached to Dual Functional Liposomes Encapsulating Dapivirine
  19. 13759
    “…Our results demonstrate in U937 cells that (i) the NGR-peptide triggers the loss of mitochondrial potential(ΔΨm) and generates superoxide anion (O(2)(−)), (ii) N-acetyl-L-cysteine (NAC) and extra/intracellular Ca(2+) chelators (BAPTA) prevent both O(2)− production and cell death, (iii) the Ca(2+)-channel blocker nifedipine prevents cell death (indicating that Ca(2+) influx is the initial death trigger), and (iv) BAPTA, but not NAC, prevents ΔΨm loss (suggesting O(2)(−) is a mitochondrial downstream effector). …”
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    The CNGRC-GG-(D)(KLAKLAK)(2) peptide induces a caspase-independent, Ca(2+)-dependent death in human leukemic myeloid cells by targeting surface aminopeptidase N/CD13
  20. 13760
    “…In some yeasts and bacterial species, pulcherriminic acid derived from cyclo-L-leucyl-L-leucyl is excreted and chelates free ferric ions to form the pulcherrimin. …”
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    The MarR-like protein PchR (YvmB) regulates expression of genes involved in pulcherriminic acid biosynthesis and in the initiation of sporulation in Bacillus subtilis
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