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  1. 13781
    “…These Ca(2+) increases were abrogated by the MS channel inhibitor Grammostola spatulata mechanotoxin 4 (GsMTx-4) or by chelation of extracellular Ca(2+). Thrombus formation was studied on collagen-coated surfaces using DiOC(6)-stained platelets. …”
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    Evidence for shear-mediated Ca(2+) entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line
  2. 13782
    “…The protective effect of flavonoids on the DNA damage caused by hydroxyl radicals through chelation is an important mechanism, though the converse may be possible, e.g., quercetin. …”
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    Food Antioxidants and Their Anti-Inflammatory Properties: A Potential Role in Cardiovascular Diseases and Cancer Prevention
  3. 13783
    “…Hyaluronan nanoparticles (HA-NPs) were prepared by reacting amine-functionalized oligomeric hyaluronan (HA) with cholanic ester and labeled with a fluorescent or radioactive label. …”
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    Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis
  4. 13784
    por Wang, Chao, Zhu, Wandi, Wang, Bao-Zhong
    Publicado 2017
    “…Click chemistry and metal-chelating reactions were used to couple the two proteins. …”
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    Dual-linker gold nanoparticles as adjuvanting carriers for multivalent display of recombinant influenza hemagglutinin trimers and flagellin improve the immunological responses in vivo and in vitro
  5. 13785
    “…Wood decayed by brown rot fungi and wood treated with the chelator-mediated Fenton (CMF) reaction, either alone or together with a cellulose enzyme cocktail, was analyzed by small angle neutron scattering (SANS), sum frequency generation (SFG) spectroscopy, Fourier transform infrared (FTIR) analysis, X-ray diffraction (XRD), atomic force microscopy (AFM), and transmission electron microscopy (TEM). …”
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    Modification of the nanostructure of lignocellulose cell walls via a non-enzymatic lignocellulose deconstruction system in brown rot wood-decay fungi
  6. 13786
    “…Slc39a14(−/−) mice develop markedly increased Mn concentrations in the brain and several extrahepatic tissues, as well as motor deficits that can be rescued by treatment with the metal chelator Na(2)CaEDTA. In contrast, Slc39a14(fl/fl);Alb-Cre(+) mice do not accumulate Mn in the brain or other extrahepatic tissues and do not develop motor deficits, indicating that the loss of Slc39a14 expression selectively in hepatocytes is not sufficient to cause Mn accumulation. …”
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    Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice
  7. 13787
    “…In addition, a null mutant deficient in citrate synthase showed an impairment for growth at high concentrations of iron chelators, and showed almost no reaction in the CAS test. …”
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    Secreted Citrate Serves as Iron Carrier for the Marine Pathogen Photobacterium damselae subsp damselae
  8. 13788
    “…INTRODUCTION: Carnosine, an over-the-counter food supplement, has a promising potential for the prevention and treatment of chronic diseases such as type 2 diabetes (T2DM), cardiovascular and neurodegenerative diseases through its anti-inflammatory, antiglycation, antioxidative and chelating effects. We have previously shown that supplementation with carnosine preserves insulin sensitivity and secretion in non-diabetic overweight and obese individuals. …”
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    Does supplementation with carnosine improve cardiometabolic health and cognitive function in patients with pre-diabetes and type 2 diabetes? study protocol for a randomised, double-blind, placebo-controlled trial
  9. 13789
    “…The combination of iron chelators, deferoxamine and diethylenetriaminepentaacetic acid, significantly inhibited the toxicity of either ascorbate alone or ascorbate following iron sucrose. …”
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    Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells
  10. 13790
    “…The application of Ca(2+) chelators or channel inhibitors and calmodulin (CaM) antagonists significantly reversed NO-induced adventitious rooting, implying that endogenous Ca(2+)/CaM might be involved in NO-induced adventitious rooting under osmotic stress. …”
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    Calcium and Calmodulin Are Involved in Nitric Oxide-Induced Adventitious Rooting of Cucumber under Simulated Osmotic Stress
  11. 13791
    “…The elevated insulin sensitivity mediated by ATP2B1 gene silencing was Ca(2+)/calmodulin-dependent, as verified by administration of the calcium chelator BAPTA-AM or the calmodulin-specific antagonist W7. …”
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    ATP2B1 gene Silencing Increases Insulin Sensitivity through Facilitating Akt Activation via the Ca(2+)/calmodulin Signaling Pathway and Ca(2+)-associated eNOS Activation in Endothelial Cells
  12. 13792
    “…A Dy(2+) complex with 18-crown-6 as the potassium chelator, [K(18-crown-6)(THF)(2)][(((Ad,Me)ArO)(3)mes)Dy], 5-Dy, was isolated as a co-crystallized mixture with the Dy(3+) hydride complex, [K(18-crown-6)(THF)(2)][(((Ad,Me)ArO)(3)mes)DyH], 6-Dy. …”
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    Comparisons of lanthanide/actinide +2 ions in a tris(aryloxide)arene coordination environment
  13. 13793
    “…Although TRPM2 activation affects the intracellular dynamics of Ca(2+) and Zn(2+), chelation of Zn(2+) alone was sufficient to prevent mitochondrial fission. …”
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    TRPM2-mediated rise in mitochondrial Zn(2+) promotes palmitate-induced mitochondrial fission and pancreatic β-cell death in rodents
  14. 13794
    “…Other iron metabolism genes like Ferric reductase (FRO), transporters (IRT, VIT and YSL) and chelators (NAS, DMAS and NAAT) were also differentially expressed in transgenic leaf and root, suggesting the multifaceted impact of MusaFer1 towards iron uptake and organ distribution. …”
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    Overexpression of native ferritin gene MusaFer1 enhances iron content and oxidative stress tolerance in transgenic banana plants
  15. 13795
    “…Both JFEE and JFBE markedly scavenge diphenylpicrylhydrazyl radical and chelate Fe(+2)in vitro. A compound was isolated from JFBE and identified using 1D and 2D (1)H- and (13)C-NMR. …”
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    Antioxidant Activity of Artocarpus heterophyllus Lam. (Jack Fruit) Leaf Extracts: Remarkable Attenuations of Hyperglycemia and Hyperlipidemia in Streptozotocin-Diabetic Rats
  16. 13796
    “…Lambs were fed a basal diet with a basal Mn content (34.3 mg/kg dry matter; control) and supplemented either with inorganic manganous sulfate or organic Mn-chelate hydrate (daily 182.7, 184 mg/kg dry matter of feed, respectively). …”
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    The effects of high dose of two manganese supplements (organic and inorganic) on the rumen microbial ecosystem
  17. 13797
    “…An intracellular calcium chelator impaired the amplitude of ABH; however, it did not affect the burst parameters. …”
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    SK channels participate in the formation of after burst hyperpolarization and partly inhibit the burst strength of epileptic ictal discharges
  18. 13798
    por Li, Xin, Jiang, Lin-Hua
    Publicado 2018
    “…Aβ(42)-induced neurotoxicity was also inhibited by treatment with TPEN used as a Zn(2+)-specific chelator. Cell imaging revealed that Aβ(42)-induced lysosomal dysfunction, cytosolic Zn(2+) increase, mitochondrial Zn(2+) accumulation, loss of mitochondrial function, and mitochondrial generation of ROS. …”
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    Multiple molecular mechanisms form a positive feedback loop driving amyloid β42 peptide-induced neurotoxicity via activation of the TRPM2 channel in hippocampal neurons
  19. 13799
    “…The probability of undergoing splenectomy within the first 10 years of life was 20%, a rate unchanged since the 1980s. Iron chelators were administered as monotherapy regimens in 95% of patients and deferasirox was prescribed in 81.3% of those cases. …”
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    A National Registry of Thalassemia in Turkey: Demographic and Disease Characteristics of Patients, Achievements, and Challenges in Prevention
  20. 13800
    “…MMP loss caused by nLDL was prevented by treatment with the intracellular Ca(2+) chelator BAPTA-AM. In mitochondrial Ca(2+) measurements using Rhod-2 AM, increased mitochondrial Ca(2+) levels by nLDL were inhibited upon preincubation with an arginase inhibitor. …”
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    Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs
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