“…Notably, Fe(3+) bound to the peptide only when stabilized toward hydrolysis, aggregation, and precipitation by a chelating ligand, binding in the region between Ser8 and Gly25. …”
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“…GEF also increased cell viability and proliferation, which could be blocked by Ki16425, an LPA1/3 receptor antagonist, or 1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester) (BAPTA-AM), a calcium chelator. We further found that GEF stimulated hyaluronic acid (HA) release from HDFs in a dose- and time-dependent manner, which could be attenuated by Ki16425, U73122, a phospholipase C inhibitor, 2-Aminoethoxydiphenyl borate (2-APB), an IP(3) receptor antagonist, and BAPTA-AM. …”
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“…In contrast to the obvious dependence of membrane β-catenin on CK stability, the detachment of β-catenin from the plasma membrane via uncoupling of cadherins by Ca2+ chelator EGTA had no effect on CK integrity. Interestingly, CHIR99021, a GSK3 inhibitor, also suppressed the CK network, resulting in the inhibition of XtiSCs cell-to-cell contacts and testicular development in juvenile frogs. …”
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“…The new ligand with multi-dentate chelating properties was fully characterized by several techniques: ESI-Mass spectroscopy, FT-IR, 1H-NMR, and single crystal X-ray diffraction. …”
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“…Thirteen patients initiated chelation after 12 months from the beginning of chronic transfusions and ferritin decline after 24 months. …”
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“…Unlike other GSK-3β inhibitors, B10 had a direct effect on Aβ by inhibiting Aβ(1-42) aggregation and promoting the Aβ(1-42) aggregate disassociation. It selectively chelated with Cu(2+), Zn(2+), Fe(3+,) and Al(3+), and targeted AD metal dyshomeostasis. …”
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“…Co(3)O(4) NPs were fabricated by a sol–gel process using cobalt chloride hexahydrate (CoCl(2)·6H(2)O) and monosodium succinate (C(4)H(5)O(4)Na) as a chelating/structure-directing agent and sodium dodecyl sulfate as a surfactant. …”
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“…Copper(II) acetate has reacted in methanol with quinaldinic acid (quinoline-2-carboxylic acid) to form [Cu(quin)(2)(CH(3)OH)]∙CH(3)OH (1) (quin(−) = an anionic form of the acid) with quinaldinates bound in a bidentate chelating manner. In the air, complex 1 gives off methanol and binds water. …”
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“…Patient: Female, 26-year-old Final Diagnosis: Juvenile hemochromatosis type 2A Symptoms: Abdominal pain • adynamia • amenorrhea • arthralgia • dark skin • diabetic ketoacidosis • dyspnea • edema of lower limbs • hair loss Medication:— Clinical Procedure: Genetic analysis • hepatic biopsy • iron chelation • magnetic resonance imaging • phlebotomy Specialty: Endocrinology and metabolic • Hematology OBJECTIVE: Rare disease BACKGROUND: Juvenile hemochromatosis is a rare genetic disease that leads to intense iron accumulation. …”
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“…Similarly, the complex in the +IV oxidation state, V(IV)O(acac)(2), dissociates to the mono-chelated species V(IV)O(acac)(+) which binds to Lyz and Ub. …”
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“…Here we evaluate the anti-HER2 sdAb 2Rs15d, coupled to diagnostic γ- and therapeutic α- and β(−)-emitting radionuclides for the detection and treatment of HER2(pos) brain lesions in a preclinical setting. 2Rs15d was radiolabeled with (111)In, (225)Ac and (131)I using DTPA- and DOTA-based bifunctional chelators and Sn-precursor of SGMIB respectively and evaluated in orthotopic tumor-bearing athymic nude mice. …”
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“…METHODS: Male C57BL/6 mice were given mixed cuprizone (CPZ, a copper chelator, 0.2 %, w/w) rodent chow for six successive weeks to induce demyelination. …”
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“…Gold nanoparticles (GNP) have been extensively explored as enhancers of external beam radiation; however, GNP have lower cellular uptake in hypoxic conditions than under normoxic conditions. Conversely, the chelator diacetyl-bis (N(4)-methylthiosemicarbazonato) copper II (CuATSM) deposits copper in hypoxic regions, allowing for dose enhancement in previously inaccessible regions. …”
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“…The water extract was assayed for phenolic compound content, radical scavenger/reducing, chelating and anti-tyrosinase effects. Through an ex vivo model of toxicity induced by lipopolysaccharide (LPS) on isolated rat colon and liver, we explored the extract effects on serotonin, dopamine and kynurenine pathways and the production of prostaglandin (PG)E(2). …”
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“…The central lanthanide ion is coordinated to four phenolato oxygen atoms from the four ligands, and four carboxylato oxygen atoms from two acetates which are bound in the bidentate chelate mode. The lattice structure of complex 4 consists of two interpenetrating, supramolecular diamond like lattices formed through hydrogen bonds among neighboring trinuclear clusters. …”
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“…Comparative proteomic analysis showed that siderophore and iron chelate transport proteins were down-regulated during mature biofilm formation. …”
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“…Pretreatment of cells with either the intracellular Ca(2+) chelator BAPTA-AM (30 μM) or the PKC inhibitor Calphostin C (100 nM) reduced the inhibitory effect of DRE. …”
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“…An age of 8 – 12 years and oral chelation therapy predicted lower self-reported PedsQL TSS. …”
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“…Between the dimer centers, the alanine molecules behave as bridging (μ(2)-O,O’-) and chelating bridging (μ(2)-O,O,O’-) ligands. The first type of bridge is present in dimers I, while both bridge forms can be observed in dimers II. …”
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“…The single-crystal X-ray structure analysis and comparative data revealed pseudo-octahedral half-sandwich 1 and 2 complexes and octahedral tetrachloroiridate(III) 3 with a rare chelating κ(2)N,O coordination mode of py(2)CO. The compounds were tested in vitro against three cancer cell lines—colorectal adenoma (LoVo), myelomonocytic leukaemia (MV-4-11), breast adenocarcinoma (MCF-7), and normal fibroblasts (BALB/3T3). …”
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