“…Lastly, HPLC analysis of the culture supernatants grown in minimal medium with or without Fe(3+) ions presented a peak corresponding to iron-chelating siderophore at a retention time of 5.12 min. …”
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“…Notably among the 109 overviewed inhibitors include quercetin, eriodictyol, baicalin, luteolin, melatonin, resveratrol and berberine from natural products, GC373, NP164 and HR2P-M2 from peptides, 5F9, m336 and MERS-GD27 from specific human antibodies, imatinib, remdesivir, ivermectin, chloroquine, hydroxychloroquine, nafamostat, interferon-β and HCQ from repurposing libraries, some iron chelators and traditional medicines. This review represents a model for further translational studies for effective anti-CoV therapeutic designs.…”
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“…The results of phosphomolybdenum assay and metal chelation showed similarity between the three species of Lupinus. …”
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“…However, the O. lycaonica showed low IC(50) or EC(50) for 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+), cupric reducing antioxidant power (CUPRAC), ferric reducing antioxidant power (FRAP) and ferrous ion chelating activity, as compared to O. papillosa. The results proved the presence of potent antioxidant compounds in O. lycaonica. …”
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“…Intact crypts obtained from normal human colonic biopsies by Ca(2+) chelation were used for patch clamp studies of basolateral IK(Ca) channels in the cell-attached configuration. …”
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“…Correspondingly, a KCNQ inhibitor and chelation of PIP(2) effectively downregulated the hyperactive WT-p.G319D concatemer channel. …”
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“…Thus, the mechanism of the biomineralization induced by E. ludwigii SYB1 can be divided into three stages: (i) the production of carbonate anhydrase and ammonia increases the alkalinity and saturation state of the milieu, (ii) free calcium and magnesium ions are adsorbed and chelated onto EPS, and (iii) nanominerals crystallize and grow within the EPS. …”
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“…The calcium sulfate filter cake can be removed easily from the wellbore with an efficiency of 83 to 91% in single-stage and multistage removal processes, respectively using the newly developed formulation consisting of 20 wt % potassium salt of glutamic acid-N,N-diacetic acid (K(4)GLDA) as a chelating agent, 6 wt % potassium carbonate, and 10% ethylene glycol monobutyl ether. …”
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“…Furthermore, brucine-induced lipid peroxidation was inhibited or exacerbated when intracellular iron was chelated by deferoxamine (500 μM) or improved by ferric ammonium citrate (500 μM). …”
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“…Mice were pretreated with the IP3R agonist carbachol, IP3R inhibitor 2-aminoethoxydiphenyl borate (2-APB) or the Ca2+ chelator BAPTA-AM. Lung tissues and bronchoalveolar lavage fluid (BALF) were collected to measure Ca2+ concentrations, inflammatory responses and mRNA/protein expression associated with ER stress, NLRP3 inflammasome activation and inflammation. …”
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“…X-ray diffraction structural analysis revealed that 1 has a one-dimensional (1D) infinite chain network through the deprotonated pca(−) monodentate chelation and with a μ(2)-bmimb bridge Co(II) atom, and 2 is a binuclear Co(II) complex construction with a pair of symmetry-related pca(−) and bimb ligands. …”
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“…Pretreatment with BAPTA-AM, a calcium chelator, blunted the upregulation of renal fibrosis genes and ER stress markers induced by S100A16 overexpression in HK-2 cells and suppressed the cytoplasmic colocalization of GRP78 and S100A16. …”
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“…The antioxidant and anti-enzymatic activities were evidenced in DPPH (10.64–82.44 mg TE/g) and ABTS (14.20–77.60 mg TE/g) radical scavenging, CUPRAC (39.94–140.52 mg TE/g), FRAP (16.05–77.00 mg TE/g), chelating (0–34.80 mg EDTAE/g), anti-acetylcholinesterase (0–2.27 mg GALAE/g), anti-butyrylcholinesterase (0.60–3.11 mg GALAE/g), anti-amylase (0.62–1.11 mmol ACAE/g) and anti-glucosidase (0–1.22 mmol ACAE/g) assays. …”
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“…Growth and leaf morphometrical traits of the studied congeneric species were affected similarly by the soil type and differently by the chelate treatment. Increased availability of Fe in Rendzina contrasted the species, as treatment with 25 µmol Fe-HBED kg(−1) soil promoted growth only in C. stoebe. …”
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“…On the other hand, lipid peroxidation and inhibition of cell death through an iron chelator suggest the involvement of ferroptosis in the GBM cell lines. …”
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“…Concerning compound-metal ionophore activity (assessed using chemical experiments), despite weak binding to Zn(2+) determined from (31)P NMR titration of 1 and 2 by ZnCl(2), compounds 1, 3, 4, 5 and 6 demonstrated ionophore assisted partition of Zn(2+) from water to octanol at micromolar concentrations with efficacy on a par with or better than the chelator MTDL clioquinol (5-chloro-7-iodo-8-hydroxyquinoline). …”
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“…Moreover, ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid (EGTA), lanthanum chloride (LaCl(3)), ruthenium red (RRed) and cyclosporine A (CS-A) were applied to (i) chelate extracellular calcium ions (Ca(2+)) as well as blocks of (ii) plasma-, (iii) endoplasmic reticulum- (ER) membrane Ca(2+) ion channels and (iv) mitochondria- (MIT) Ca(2+) ions release by permeability transition por (PTP), respectively. …”
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“…The novel chelator, L-glutamic acid, N,N-diacetic acid (GLDA) can be used as a dietary ingredient to safely reduce Zn supplementation in complete feed, without compromising the Zn status of farm animals. …”
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“…Bath application of apamin to block SK2 did not alter AMH effect on increasing EPSPs, whereas blocking Kv4.2 channel with 4-aminopyridine, or chelating internal Ca(2+) with BAPTA occluded the action of AMH on boosting EPSPs. …”
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“…Intraperitoneal (i.p.) injection of an iron chelate, ferric nitrilotriacetate (Fe‐NTA), produces hydroxyl radicals via Fenton reaction to induce ferroptosis in renal proximal tubules. …”
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