“…Each of the three crystallographically independent Cu atoms is octahedrally sited with cis-arrangements two N-donors from two different ligands 1 and, therefore, cis-arrangements of coordinated [hfacac](−) ligands; this observation is unusual among compounds in the Cambridge Structural Database containing {Cu(hfacac)(2)N(2)} coordination units in which the two N-donors are in a non-chelating ligand.…”
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“…RESULTS: In this study, polyethylene glycol-phenylboronic acid (PEG-PBA)-modified generation 5 (G5) poly(amidoamine) (PAMAM) dendrimers were synthesized as a targeted nanocarrier to chelate Cu(II) and then encapsulate hypoxia-sensitive drug tirapazamine (TPZ) by the formation of hydrophobic Cu(II)/TPZ complex for hypoxia-enhanced chemo/chemodynamic therapy. …”
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“…Dis cytotoxicity in cancer cells has been shown to be copper-dependent, in part due to Dis's ability to function as a bivalent metal ion chelator of copper (Cu). The objectives of this research were to test ALDH expression levels and Cu concentrations in sarcoma patient tumors and human osteosarcoma (OS) cell lines with differing metastatic phenotypes. …”
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“…Mechanistically, mitochondrial impairment sufficient to induce TAU-missorting results in decreases of calcium oscillation but increases in baseline calcium, yet chelating intracellular calcium did not prevent mitochondrial impairment-induced TAU-missorting. …”
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“…All fractions showed excellent antioxidant activity in the Oxygen Radical Absorbance Capacity (ORAC) assay (5.76–221.81 g Trolox/g DE), ABTS(•+) radical scavenging ability (0.62 ± 0.03 – 5.09 ± 0.23 g Trolox/g DE), and moderate ion (Fe(2+)) chelating power. This paper expands our knowledge of the phytochemistry and pharmacological activity of R. luteum polyphenols. …”
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“…Pd(2)Spm is a dinuclear palladium(II)-spermine chelate with promising anticancer properties against triple-negative breast cancer (TNBC), a breast carcinoma subset with poor prognosis and limited treatment options. …”
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“…The stimulatory effect was potentiated by glucose and isobutyl methylxanthine (IBMX), persisted in presence of tolbutamide or a depolarizing concentration of KCl but was attenuated by established inhibitors of insulin release such as diazoxide, verapamil, and Ca(2+) chelation. HWHF caused depolarization of the β-cell membrane and increased intracellular Ca(2+). …”
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“…Antioxidant capacity was investigated by different assays, including phosphomolybdenum assays, radical scavenging (DPPH: 2,2-diphenyl-1-picrylhydrazyl; ABTS: 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)), as well as reducing ability (CUPRAC: cupric reducing antioxidant capacity; FRAP: ferric reducing antioxidant power), and metal chelating. In radical scavenging and reducing power assays, the water extract of aerial parts exhibited the strongest ability (DPPH: 36.99 mg trolox equivalent (TE)/g; ABTS: 85.96 mg TE/g; CUPRAC: 87.37 mg TE/g; FRAP: 55.43 mg TE/g). …”
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“…Ciclopirox (CPX), an iron chelator commonly used to treat fungal infections, which has recently been shown to have antitumor activity against a variety of cancers including both solid tumors and hematological malignancies in vitro and in vivo. …”
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“…To mitigate earlier problems with a lack of selectivity for Pb vs. zinc, we preincubated samples with tricine, a low-affinity zinc chelator. We validated the pMet-lead measurements of the characterized laboratory samples and unknown samples from six regions in Taiwan by inductively coupled plasma mass spectrometry (ICP-MS). …”
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“…To determine if altered cardiac iron status modifies ABCB8 expression, we treated cardiomyocytes with high iron or iron chelators. Western blot and qPCR analyses revealed that ABCB8 levels were decreased in iron overload and increased in iron deficiency. …”
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“…Neurological evaluation of seizures revealed uncommon choroid plexus hemosiderosis by brain magnetic resonance imaging, warranting appropriate selection of iron chelation therapy in the context of preexisting nephropathy. …”
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“…In HEY cells, provided with a high intracellular labile iron pool, erastin treatment is accompanied by NCOA4-mediated ferritinophagy and mitochondrial dysfunction, thus triggering ferroptosis. In agreement, iron chelation counteracts erastin-induced ferroptosis in these cells. …”
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“…FT-IR analysis revealed a chelating (1 and 2) and a bridging bidentate (3 and 4) coordination modes for the carboxylate ligand in solid state which was further confirmed by the single crystal X-ray analysis of complex 4. …”
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“…A similar antiapoptotic effect was obtained by Ca(2+)(cyt) chelating using BAPTA. These data indicate that NUP-induced cell death is mediated, at least in part, by the induction of oxidative stress and Ca(2+)(cyt) accumulation. …”
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“…The large Brunauer–Emmett–Teller specific surface area (376 m(2) g(−1)) and narrow pore size distribution (2–20 nm) of the prepared compact alumina suggest that the chelating effect of the acetate ions affects the structures of the forming transition aluminas, and the evolved gases produced by decomposition of Al(OH)(CH(3)COO)(2) and NH(4)NO(3) as a by-product of the reaction during calcination prevent particle agglomeration. …”
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“…Each structure contains a Zn(II) atom chelated by one tetradentate twisted ligand L(I) creating the unusual Möbius type topology. …”
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“…The HOMOs of 1–3 are composed of d(Ir) and π(cyclometalated ligands), however, the HOMO of 4 resides on the pyim ligand, while the LUMOs of all four complexes are dominantly localized on the chelating ligands. The calculated absorption results show that the corresponding absorption peaks for the four mainly studied complexes are almost at the same positions, however, the absorption intensities of the bands differ largely from each other. …”
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“…Due to the substantial increase in bioavailability of the two iron chelating drugs, the results from this study strongly recommend their co-administration.…”
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“…The method is based on selective binding of fluoride to a lanthanum chelate complex that gives a purple-colored product. …”
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