“…In addition, the ACHNs hydrolysates showed the highest antioxidant activity (DPPH IC(50) = 0.553 ± 0.009 mg/mL, ABTS IC(50) = 0.219 ± 0.019 mg/mL, and Fe(2+) chelating activity IC(50) = 40.947 ± 3.685 μg/mL). …”
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“…The antioxidant and enzyme inhibitory properties were shown in the DPPH (0.71–213.68 mg TE/g) and ABTS (20.57–356.35 mg TE/g) radical scavenging, CUPRAC (38.56–311.21 mg TE/g), FRAP (121.68–202.34 mg TE/g), chelating (12.88–22.25 mg EDTAE/g), phosphomolybdenum (0.92–2.11 mmol TE/g), anti-acetylcholinesterase (0.15–3.64 mg GALAE/g), anti-butyrylcholinesterase (0–3.18 mg GALAE/g), anti-amylase (0.05–0.38 mmol ACAE/g), anti-glucosidase (0.43–2.21 mmol ACAE/g), and anti-tyrosinase (18.62–48.60 mg KAE/g) assays. …”
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“…Targeted thorium-227 conjugates comprise the combination of a monoclonal antibody with specificity for a tumor cell antigen and a 3,2-HOPO chelator enabling complexation of thorium-227 (Th-227). …”
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“…Adding micromolar Ca(2+) blocked vacuole acidification, whereas chelating Ca(2+) accelerated acidification. The effect of adding Ca(2+) on acidification was eliminated when the Ca(2+)/H(+) antiporter Vcx1 was absent, indicating that the vacuolar H(+) gradient can collapse during Ca(2+) stress through Vcx1 activity. …”
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“…Hydrogen peroxide liberated from enzyme–substrate reactions was determined by the cupric ion reducing antioxidant capacity (CUPRAC) reagent, bis-neocuproine copper(II) chelate. In addition, UA-free total antioxidant capacity could also be measured via the developed system. …”
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“…Charge decomposition analysis (CDA) of the DFT-modeled species with the dissociated triazolyl group revealed a pseudo-η(3)-allylic interaction between the π-type MOs of the transformed anthracenyl group and the Rh(III) center; thus, the singly attached chelating ligand is classified as having rare nonadenticity.…”
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“…In addition, (89)Zr was labeled after chelating AE17 OMVs by DFO and positron emission tomography PET imaging was used to track (89)Zr-DFO-OMVs in chickens and to pathologically analyze the distribution sites. …”
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“…METHODS: Hydrophilic hyaluronic acid (HA) was covalently modified with a hydrophobic 5β-cholanic acid (CA) via an ROS-cleavable thioketal (tk) linker for a targeted co-deliver of 10-Hydroxy camptothecin (HCPT) and Chlorin e6 (Ce6) into tumors to improve the efficiency of combined chemo-photodynamic therapy. …”
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“…RHA (0.1 mg/mL) also exhibited antioxidant activity for the following tests: total antioxidant capacity (286.86 mg AAE/g), iron (87.16%) and copper (25.64%) chelation, and superoxide scavenging (10%). In the cell culture assays, RHA (0.1 mg/mL) promoted regeneration of metabolic activity (92% cell viability) in cells exposed to oxidative stress. …”
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“…In contrast, the fluorescence enhancement in the case of Pb(II) and As(III) could be correlated to the chelation-enhanced fluorescence phenomenon. These results indicate that MA-1@CNT is an ideal sensor for Pb(II), As(III), Cr(VI), and NB recognition.…”
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“…Total phenolic content (TPC), total flavonoid content (TFC), as well as metal ion chelation (MIC) and DPPH radical activity of the different extracts were assessed. …”
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“…2-Formylpyridine thiosemicarbazone - iron (III) chelates [[Formula: see text]] [Formula: see text] {L = L(1) (C1) [HL(1) = 4-(4-Nitrophenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide] and L = L(2) (C2) [HL(2) = 4-(2,5-Dimethoxyphenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide]} were prepared. …”
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“…Deferiprone can pass through the blood-retinal barrier after oral administration and chelated abnormally elevated ferrous iron in the retina after ph-IOP injury, thus inhibiting RGC ferroptosis and protecting visual function. …”
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“…Thus, (224)Ra targets stromal elements in sclerotic bone metastases and (212)Pb-chelated-conjugate targets tumor cells of metastatic prostate cancer or osteosarcoma. …”
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“…Molecular orbital energy and spin density analysis indicate that the sulfhydryl (-SH) group of molecules has the greatest electron donating activity, which would be responsible for the antioxidant potential and free radical scavenging activity. α-Lipoic acid acts as a chelating agent for metal ions, a quenching agent for reactive oxygen species, and a reducing agent for the oxidized form of glutathione and vitamins C and E. α-Lipoic acid enantiomers and its reduced form have antioxidant, cognitive, cardiovascular, detoxifying, anti-aging, dietary supplement, anti-cancer, neuroprotective, antimicrobial, and anti-inflammatory properties. α-Lipoic acid has cytotoxic and antiproliferative effects on several cancers, including polycystic ovarian syndrome. …”
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“…In vitro, antioxidant properties of PC were determined in terms of Fe(3+) reducing, metal chelating, lipid peroxidation and superoxide scavenging ability. …”
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“…However, zinc in the seminal plasma is diluted and chelated upon addition of extenders for storage, potentially reducing its antioxidant effect. …”
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“…The aromatic sulfonamide moiety was included as a known direct inhibitor of carbonic anhydrase IX activity through its zinc chelating property. The chalcone moiety was incorporated as an electrophilic stressor to indirectly inhibit carbonic anhydrase IX cellular activity. …”
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“…Long-term safety and efficacy data on the iron chelator deferiprone in sickle cell disease (SCD) and other anemias are limited. …”
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“…Thus, comprehensive molecular docking testing of the INSTIs, DTG, bictegravir (BIC), and cabotegravir (CAB), against twenty-three human MMPs showed broad-spectrum inhibition. With a metal chelating chemical property, each of the INSTI were shown to bind Zn++ at the MMP’s catalytic domain leading to MMP inhibition but to variable binding energies. …”
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