“…However, currently available FAP imaging agents both contain chelator groups to enable radio-metal labeling, making those tracers more hydrophilic and not suitable for the imaging of lesions in the brain. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The k(1)-acetate iminol (C=N-OH) unit of the mer-tautomer k(1)(O)-(Ru(CO)(PPh(3))(2)(THAc)) (2) likely exhibits a stronger nucleophilic aptitude than the prevalent N(H)-C(O) amido species, thus accomplishing extra stabilization through concomitant k(2)(N,O)-thymine heteroleptic side-chelation. Furthermore, both the ESI-Ms and IR simulation spectra validated the related dimeric arrangement in solution, in agreement with the X-ray determination of the structure. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Currently, ethylene diamine tetraacetic acid (EDTA) chelation remains the most important treatment. However, only the safety of low-dose topical EDTA eye drops is well established in humans. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Methods: The ligand HYNIC-iPSMA was chosen as the lead structure. Its HYNIC chelator has limitations for (188)Re labeling and was replaced by mercaptoacetyltriserine to obtain PSMA-GCK01, a precursor for stable (99m)Tc and (188)Re labeling. (99m)Tc-PSMA-GCK01 was used for in vitro evaluation of the ligand and comparison with (99m)Tc-EDDA/HYNIC-iPSMA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We developed a prostate-specific membrane antigen (PSMA) ligand consisting of a DOTA chelator for (111)In labeling and a fluorophore/photosensitizer IRDye700DX (PSMA-N064). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…FAP-2286 is a radiopharmaceutical in clinical development for solid tumors that consists of two functional elements: a FAP-targeting peptide and a chelator used to attach radioisotopes. Preclinically, we evaluated the immune modulation and anti-tumor efficacy of FAP-2287, a murine surrogate for FAP-2286, conjugated to the radionuclide lutetium-177 ((177)Lu) as a monotherapy and in combination with a PD-1 targeting antibody. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…DARPins were site-specifically functionalised at a unique C-terminal cysteine with a hexadentate aza-nonamacrocyclic chelate (NODAGA) for subsequent radiolabelling with the positron-emitting radionuclide (68)Ga. [(68)Ga]GaNODAGA-DARPins showed high stability toward transchelation and were stable in human serum for >2 h. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…OBJECTIVES: Leptomeningeal metastases (LM) are an increasing complication of metastatic cancer with limited treatment options and poor survival. 186RNL is BMEDA-chelated 186Re encapsulated in nanoliposomes. 186Re’s ~2 mm beta emission path length provides direct delivery of radiation therapy while sparing surrounding healthy tissue. …”
Enlace del recurso
Enlace del recurso

“…In vitro decalcification with Ca-chelating agents (0.5 M EDTA solution, pH 7.4) was used. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Interaction analysis revealed that the target compounds interact with Gln239, Tyr310, Tyr329, Arg383 and Trp389 residues, and chelate the active site iron in a bidentate manner in PHD2. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These two radiotracers bind calcium mineral deposits via different mechanisms, with BPs chelating to calcium ions and thus being non-selective, and [(18)F]NaF being selective for hydroxyapatite (HAp) which is the main component of bone mineral. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Thus, we propose that chelation of iron requires further investigation as a therapeutic strategy in SCD.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Based on our findings, the disks buried in situ were selected and used as disposable substrates to study the cleaning effect of a novel polyvinyl alcohol (PVA)-based gel loaded with a chelating agent (Na(2)EDTA · 2H(2)O). Results show that the gel is effective in removing disfiguring degradation compounds and preserving the stable and protective patina. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Hence, EOs were assessed for the ability either to chelate metal ions, thus interfering with ROS generation within the respiratory chain, or to neutralize 2,2-diphenyl-1-picrylhydrazyl (DPPH(•)) and lipid peroxide radicals (LOO(•)), thereby halting lipid peroxidation, as well as to neutralize 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid cation radicals (ABTS(•+)) and hydroxyl radicals (OH(•)), thereby preventing the ROS species from damaging DNA nucleotides. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…(1) Background: In neuroendocrine tumors (NETs), somatostatin receptor subtype 2 is highly expressed, which can be targeted by a radioactive ligand such as [(177)Lu]Lu-1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-tetraacetic acid-[Tyr(3),Thr(8)]-octreotide ((177)Lu-DOTA-TOC) and, more recently, by a lead specific chelator (PSC) containing (203/212)Pb-PSC-PEG(2)-TOC (PSC-TOC). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Neutralization consists of treating cultures with a chemical compound known to react with or to chelate the metal. Treated cultures are plated onto rich agar to allow metal complexes to diffuse into the recovery medium while bacteria remain on top to recover. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We used sulfasalazine and curcumin, which are well-described inhibitors of NF-kappaB activity, and we used ethylenediamine tetraacetic acid to deplete extracellular Ca2+ or used the cell-permeable agent 1,2-bis (2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid tetra (acetoxymethyl) ester to chelate releasable intracellular stores of Ca2+ in order to investigate the mechanisms through which M. bovis BCG induces IL-8 secretion in our system. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Initial small-scale expression and purification under native conditions by metal chelate affinity chromatography indicated that the vast majority of target proteins were purified in high yields. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this hypotonic, calcium-chelating solution, the cell lysed within 1.5 min, and after a brief, transient rise, the BR disappeared in ca. 4 min from the time of buffer application. …”
Enlace del recurso
Enlace del recurso

“…In cultured chick lens cells, A- CAM was associated with Ca2+-dependent junctions that were cleaved upon a decrease of extracellular Ca2+ concentrations to less than or equal to 0.5 mM. In the chelator-separated junction, A-CAM became exposed to exogenously added antibodies or to proteolytic enzymes. …”
Enlace del recurso
Enlace del recurso