“…We also found that silibinin/TRAIL-induced apoptosis was accompanied with intracellular influx of Ca(2+), which was stimulated by ER stress and the Ca(2+) chelator, ethylene glycol tetraacetic acid (EGTA). …”
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“…Inhibition of human metalloproteases by metal‐chelating antibiotics contributes to the utility of local therapy. …”
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“…Current treatment of this disease involves regular blood transfusion and adjunct chelation therapy to lower blood transfusion–induced iron overload. …”
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“…HPT was significantly associated with the mean received blood per transfusion (P = 0.009), total transfused blood per year (P = 0.01), splenomegaly (P < 0.001), splenectomy (P < 0.001), hepatomegaly (P = 0.01), and chelation regimen (P < 0.001). The ferritin level was correlated with neither HT nor HPT. …”
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“…In this study we aimed to identify such metabolites and therefore we utilized the siderophore-based bifunctional chelator fusarinine C (FSC) for the design of novel mono- and multimeric constructs, bearing minigastrin (MG) analogues as targeting moieties to address cholecystokinin-2 receptors (CCK2R) which are overexpressed in a variety of cancerous diseases and are well known for fast enzymatic degradation, particularly for truncated des-(Glu)(5)-MG members, such as MG11. …”
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“…Regression models for FAPAR (monthly images) gave an R-square of 90% with the most important predictors being total annual precipitation, monthly cloud fraction, CHELSA bioclimatic layers, and month of the year, respectively. …”
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“…Material and methods: Antioxidant activity was determined (up to 1 mg/mL) as radical-scavenging activity (RSA) of 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), copper (CCA) and iron (ICA) chelating activities and iron reducing power (FRAP). …”
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“…Context: Rutin (RUT) is an antioxidant flavonoid with well-known metal chelating potentials. Objective: This study was designed to evaluate the protective effects of RUT against cadmium (Cd) + ethanol (EtOH)-induced hepatic and renal toxicity in rats. …”
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“…Despite the functional redundancy of EfaCBA, MntH1 and MntH2 under in vitro or ex vivo conditions and in the invertebrate model, dual inactivation of efaCBA and mntH2 (ΔefaΔmntH2 strain) was sufficient to prompt maximal sensitivity to calprotectin, a Mn- and Zn-chelating host antimicrobial protein, and for the loss of virulence in mammalian models. …”
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“…The antioxidant activity of partially purified extract (PPE) (DPPH, ABTS, FRAP and Metal chelating activity) were observed and were also found to have significant cytotoxic activity against HT-29, MDA and U-87MG cell lines. …”
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“…MHMEPS showed antioxidant scavenging activity against DPPH•, H(2)O(2) and Metal chelating activity, respectively. So, reducing power method give high activity at 500 µg/ml. …”
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“…Cytotoxicity was evaluated in both PANC-1 and KPC (Kras(LSL-G12D/+); Trp53(LSL-R172H/+); Pdx-Cre) pancreatic cancer cell lines. A (64)Cu chelator (2-S-(4-aminobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid, NOTA) was squalenoylated and used with positron emission tomography (PET) imaging to monitor the in vivo fate of SqGem-based NPs. …”
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“…Finally, several vacuolar NA chelating heavy metal transporters were vigorously activated. …”
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“…None of the children in this study had blood lead level (BLL) that required chelation treatment according to Vietnam MOH guideline (BLL ≥45 μg/dL). …”
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“…The study aimed to determine the effects of methionine hydroxy analog chelate zinc on the tibia quality, mineral deposit, apparent retention of nutrients, and liver metallothionein (MT) expression level of aged laying hens. …”
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“…The PTT nanoparticles having a peculiar synergic combination of four kinds of active groups, S–, –SH, N–N, and =N– with a small particle size of 30–200 nm exhibit ultrarapid initial adsorption rates of 1500 mg(Hg)·g(−1)·h(−1) and 5364 mg(Ag)·g(−1)·h(−1) and high adsorption capacities of up to 186.9 mg(Hg)·g(−1) and 193.1 mg(Ag)·g(−1), becoming ultrafast chelate nanosorbents with high adsorption capacities. …”
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“…Then, 9E7.4 was conjugated to TE2A-benzyl isothiocyanate (TE2A) and desferrioxamine (DFO) chelators for (64)Cu and (89)Zr labeling, respectively. (64)Cu-TE2A-9E7.4 and (89)Zr-DFO-9E7.4 antibodies were evaluated by PET imaging and biodistribution studies in C57BL/KaLwRij mice bearing either 5T33-MM subcutaneous tumors or bone lesions and were compared to (18)F-FDG-PET imaging. …”
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“…The in situ (1)H NMR spectra suggest that the exchanges of chelating ligands such as alkyl groups and divalent anionic η(3):η(1)-FluSiMe(2)N(t)Bu ligands between rare earth metal centers and Al centers result in the formation of a heterobimetallic tetraalkylaluminate complex R(2)Al(μ-R)(2)Ln(R)(μ-R)(2)AlR(2), which is activated by activators to form a divalent cationic species [Ln(μ-R)(2)AlR(2)](2+) as a catalytically active species in the coordination–insertion polymerization of olefins.…”
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“…Although this is a rare and potentially fatal inborn error of metabolism, early diagnosis and continuous chelation therapy might improve the symptoms and prevent disease progression.…”
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“…This study provides clues which further our understanding of the structure-activity relationships of Mn(II)-chelates and suggests that Mn(II)-polyamino-polycarboxylate macrocycles could be developed as new anti-oxidant drugs.…”
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