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  1. 14161
    “…Probenecid, included in the buffers to prevent extrusion of Fura-2 dye from cells, was found to interfere with the EGTA-chelation of calcium, required to determine R(min) for quantitation of [Ca(2+)](i). …”
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    Quantitative high-throughput assay to measure MC4R-induced intracellular calcium
  2. 14162
    “…For TRT, we used (90)Y chelated to NM600, an alkylphosphocholine analog that exhibits selective uptake and retention in tumor cells including B78 and MOC2. …”
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    Temporal analysis of type 1 interferon activation in tumor cells following external beam radiotherapy or targeted radionuclide therapy
  3. 14163
    “…Enzyme kinetics were analyzed using Lineweaver-Burk and Dixon plots and nonlinear curve-fitting to determine the mechanism for tyrosinase inhibition. Copper chelating activity, using pyrocatechol violet dye indicator assay, and antioxidant activity, using a DPPH radical scavenging assay, were also conducted. …”
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    Novel Chemically Modified Curcumin (CMC) Derivatives Inhibit Tyrosinase Activity and Melanin Synthesis in B16F10 Mouse Melanoma Cells
  4. 14164
    “…The aggregated probe also has the ability to recognize Cu(2+) from a purely aqueous medium via the chelation-enhanced quenching (CHEQ) mechanism, leading to ∼84% fluorescence quenching with a Stern–Volmer quenching constant of 1.46 × 10(4) M(–1) and with an appreciably low detection threshold of 57.2 ppb, far below than recommended by the World Health Organization (WHO) and the United States Environmental Protection Agency (U.S. …”
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    Trace-Level Humidity Sensing from Commercial Organic Solvents and Food Products by an AIE/ESIPT-Triggered Piezochromic Luminogen and ppb-Level “OFF–ON–OFF” Sensing of Cu(2+): A Combined Experimental and Theoretical Outcome
  5. 14165
    “…However, regular evaluation of serum ferritin levels, close monitoring in a proper institute, suitable and acceptable treatment methods besides regular chelation therapy could significantly reduce the patients’ complications.…”
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    A Systematic Review and Meta-Analysis of Stature Growth Complications in β-thalassemia Major Patients
  6. 14166
    “…We have developed a long-term tumor-targeting peptide DOTA-EB-cRGDfK, which combines a DOTA chelator, a truncated Evans blue dye (EB), a modified linker, and cRGDfK peptide. …”
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    Molecular Imaging and Preclinical Studies of Radiolabeled Long-Term RGD Peptides in U-87 MG Tumor-Bearing Mice
  7. 14167
    “…We have previously developed mitochondria-targeted hydroxycinnamic acid derivatives, presenting antioxidant and iron-chelating properties, and preventing oxidative stress in several biological models of disease. …”
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    A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients
  8. 14168
    “…Lettuce grown in the commercial hydroponic solution were deficient in several mineral nutrients (Mg, Ca, Na, and Si) nor did they have higher iron concentrations despite the significantly higher EDTA-chelated aqueous iron (460 × greater than other treatments) in the nutrient solution. …”
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    Improving Plant Health Through Nutrient Remineralization in Aquaponic Systems
  9. 14169
    “…Similar to Hamp1 silencing, increased intracellular Fe(2+) prevented Cd(2+) damage, ROS formation and catalase disruption whereas chelation of intracellular Fe(2+) with desferrioxamine augmented Cd(2+) damage, corresponding to hepcidin upregulation. …”
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    Role of hepcidin in oxidative stress and cell death of cultured mouse renal collecting duct cells: protection against iron and sensitization to cadmium
  10. 14170
    “…In Exp. 3, cells were preincubated with 0 or 50 μmol/L Zn as iZn or organic Zn lysine chelate (oZn) for 8 h under NT, and then incubated with the same Zn treatments under NT or HT for 4 or 6 h. …”
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    Zinc alleviates the heat stress of primary cultured hepatocytes of broiler embryos via enhancing the antioxidant ability and attenuating the heat shock responses
  11. 14171
    “…In addition, hyaluronic acid (HA) was coated on the cerium’s surface to target CD44-overexpressing tumor cells, and (nat)Zr was chelated on the Fe(3)O(4)@CeO(2) surface to show the usefulness of labeling the radioisotope (89)Zr (T1/2 = 3.3 d). …”
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    Synthesis of Hyaluronic Acid-Conjugated Fe(3)O(4)@CeO(2) Composite Nanoparticles for a Target-Oriented Multifunctional Drug Delivery System
  12. 14172
    “…A. hierochuntica presented superior antioxidant activity by inhibiting linoleic acid radicals and chelating oxidation metals. The HPLC analysis resulted in 9 and 21 phenolic acids and 6 and 2 flavonoids in KEE and KAE with a predominance of sinapic and syringic acids, respectively. …”
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    Antioxidant Activity, Phenolic Profile, and Nephroprotective Potential of Anastatica hierochuntica Ethanolic and Aqueous Extracts against CCl(4)-Induced Nephrotoxicity in Rats
  13. 14173
    “…The 4 dietary treatments were arranged in a 2 × 2 factorial design, with 2 Cu sources (125 mg/kg Cu from copper methionine hydroxy analogue chelate (Cu-MHAC) or copper sulfate (CuSO(4))) and 2 phytase levels (0 or 1500 phytase units (FTU)/kg). …”
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    Interactive Effects of Copper Sources and a High Level of Phytase in Phosphorus-Deficient Diets on Growth Performance, Nutrient Digestibility, Tissue Mineral Concentrations, and Plasma Parameters in Nursery Pigs
  14. 14174
    “…Cuprizone, copper chelator, treatment of mouse is a toxic model of multiple sclerosis (MS) in which oligodendrocyte death, demyelination and remyelination can be observed. …”
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    Investigation of neuro-inflammatory parameters in a cuprizone induced mouse model of multiple sclerosis
  15. 14175
    “…Clioquinol (CQ) is a metal-protein attenuating compound with mild chelating effects for Zn(2+) and Cu(2+), and CQ can not only detach metals from SPs, but also decrease amyloid aggregation in the brain. …”
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    Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein
  16. 14176
    “…The ligand L adopts its energetically favored conformation with five-membered and six-membered chelate rings in gauche and chair conformations, respectively. …”
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    Crystal structure of trans-di­aqua­(1,4,8,11-tetra­aza­undeca­ne)nickel(II) bis­(pyridine-2,6-di­carboxyl­ato)nickel(II)
  17. 14177
    “…All SPIO@PEG-GdDTPA nanocomposites with 8 nm spherical SPIO nanocrystals showed good Gd(3+) chelate stability. SPIO@PEG-GdDTPA0.94 nanocomposites with lowest Gd/Fe molar ratio show no cytotoxicity to Raw 264.7 cells as compared to SPIO@PEG-GdDTPA1.28 and SPIO@PEG-GdDTPA1.67. …”
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    Integration of PEG-conjugated gadolinium complex and superparamagnetic iron oxide nanoparticles as T(1)–T(2) dual-mode magnetic resonance imaging probes
  18. 14178
    “…PURPOSE: Association of the metal chelating portion of thiosemicarbazone with the cytotoxic activity of sigma-2 receptors appears a promising strategy for the treatment of pancreatic tumors. …”
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    Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models
  19. 14179
    “…Besides, our data showed that zinc ion (Zn(2+)) chelator TPEN clearly increased the response of mannose-insensitive cells to mannose by inhibiting enzyme activity of PMI, while Zn(2+) supplement could effectively reverse this effect. …”
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    ZIP10 is a negative determinant for anti-tumor effect of mannose in thyroid cancer by activating phosphate mannose isomerase
  20. 14180
    “…In the present study, in-silico pharmacokinetic properties (ADME), drug-likeness, toxicity profiles of sixteen antidiabetic flavonoids that have ideal bidentate chelating sites for metal ion coordination were examined using SwissADME, Pro Tox II, vNN and ADMETlab web tools. …”
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    Pharmacokinetics and drug-likeness of antidiabetic flavonoids: Molecular docking and DFT study
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