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  1. 14221
    “…For the purposes of animal nutrition and to increase the bioavailability of this element, this research focuses on the use of chelates or proteinaceous iron preparations. Casein proteins possess excellent iron-binding properties, thereby decreasing their susceptibility to oxidation and therefore possessing high bioavailability. …”
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    Effects of Iron Supplementation on Metabolism in Calves Receiving Whole Milk
  2. 14222
    “…All conjugates were effective chelators of Cu(2+), Fe(2+), and Zn(2+), with molar compound/metal (Cu(2+)) ratios of 2:1 (5b) and ~1:1 (10b). …”
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    Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer’s Disease
  3. 14223
    “…Phytic acid is a natural chelating compound that shows antioxidant and osteogenic properties that can play an important role in bone remodelling processes affected by oxidative stress environments, such as those produced during infections. …”
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    New Insights into the In Vitro Antioxidant Routes and Osteogenic Properties of Sr/Zn Phytate Compounds
  4. 14224
    “…We conjugated (212)Pb, an in vivo generator of alpha-emitting (212)Bi and (212)Po, to YS5 through the chelator TCMC to create the radioimmunoconjugate, (212)Pb-TCMC-YS5. …”
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    CD46 targeted (212)Pb alpha particle radioimmunotherapy for prostate cancer treatment
  5. 14225
    “…These nanoparticles (NPs) are chelated with Gd(3+) to provide suitable contrast. …”
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    Synthesis and characterization of Gd(3+)-loaded hyaluronic acid-polydopamine nanoparticles as a dual contrast agent for CT and MRI scans
  6. 14226
    “…Moreover, both dye-based and genetically encoded calcium indicator imaging rely on calcium chelation, affecting the culture’s long-term physiology. …”
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    Electrically-evoked oscillating calcium transients in mono- and co-cultures of iPSC glia and sensory neurons
  7. 14227
    “…Moreover, addition of the Ca2+ chelator BAPTA improved AC activity, but the effect was minimal. …”
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    Nitric oxide augments signaling for contraction in hypoxic pulmonary arterial smooth muscle—Implications for hypoxic pulmonary hypertension
  8. 14228
    “…The natural history of the disease is radically changed after the introduction of iron chelation therapy, which prolongs life expectancy but also allows new comorbidities to become more prevalent. …”
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    Non-Vitamin K Antagonist Oral Anticoagulants in Patients with β-Thalassemia
  9. 14229
    “…Objective: Deferasirox is an iron-chelating agent prescribed to patients with iron overload. …”
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    Genetic polymorphisms influencing deferasirox pharmacokinetics, efficacy, and adverse drug reactions: a systematic review and meta-analysis
  10. 14230
    “…Low-molecular-mass iron chelators, termed siderophores, have been shown to play a central role in iron homeostasis and, consequently, virulence of this mold. …”
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    The Siderophore Ferricrocin Mediates Iron Acquisition in Aspergillus fumigatus
  11. 14231
    “…The mechanism of action for DTG involves chelation of Mg(2+) ions in the active site of the viral integrase. …”
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    Gene-nutrient interactions that impact magnesium homeostasis increase risk for neural tube defects in mice exposed to dolutegravir
  12. 14232
    “…METHODS: Iron deficiency was induced in primary mouse embryonic hippocampal neuron cultures with the iron chelator deferoxamine (DFO) beginning at 3 days in vitro (DIV). …”
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    Cellular Iron Deficiency Disrupts Thyroid Hormone Regulated Gene Expression in Developing Hippocampal Neurons
  13. 14233
    “…Additionally, it occurred a potential role in the suppression of Alzheimer’s disease risk factors through its antioxidant (metal chelation, radical scavenging capability), anti-tyrosinase and anti-inflammatory characteristics. …”
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    Characterization of biologically active exopolysaccharide produced by Streptomyces sp. NRCG4 and its anti-Alzheimer efficacy: in-vitro targets
  14. 14234
    por Kontoghiorghes, George J.
    Publicado 2023
    “…The iron chelating orphan drug deferiprone (L1), discovered over 40 years ago, has been used daily by patients across the world at high doses (75–100 mg/kg) for more than 30 years with no serious toxicity. …”
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    The Vital Role Played by Deferiprone in the Transition of Thalassaemia from a Fatal to a Chronic Disease and Challenges in Its Repurposing for Use in Non-Iron-Loaded Diseases
  15. 14235
    “…Primary myometrial cells were treated with G protein inhibitors, calcium chelators and/or PGF2α. Nuclear extracts were analysed by TranSignal cAMP/Calcium Protein/DNA Array. …”
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    Prostaglandin F2α requires activation of calcium-dependent signalling to trigger inflammation in human myometrium
  16. 14236
    “…OBJECTIVES: 186RNL is BMEDA-chelated 186Re encapsulated in nanoliposomes. 186Re’s ~2 mm beta emission path length provides direct delivery of radiation therapy while sparing surrounding healthy tissue. 186RNL is delivered via convection enhanced delivery (CED) to achieve durable, localized tumor retention with high absorbed radiation doses. …”
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    TIPS-23 SAFETY AND FEASIBILITY RESULTS FROM A PHASE 1/2 CLINICAL TRIAL OF RHENIUM (186RE) OBISBEMEDA (186RNL) IN RECURRENT GLIOMA: THE RESPECT-GBM TRIAL
  17. 14237
    “…Here, we have prepared and characterized a series of water-soluble ruthenium-arene complexes with N,N′-chelating ligands: [Ru(II)-η(6)-arene-(4,4′-(X)(2)-2,2′-bipyridine)Cl]Cl (arene = p-cymene, X = C(4)H(9) (1), COOH (2), COOCH(3) (3), COOC(2)H(5) (4); arene = benzene, X = C(4)H(9) (5), COOCH(3) (6), COOC(2)H(5) (7)). …”
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    Effective and Selective Ru(II)-Arene Complexes Containing 4,4′-Substituted 2,2′ Bipyridine Ligands Targeting Human Urinary Bladder Cancer Cells
  18. 14238
    “…METHODS: PEGylated and non-PEGylated MNPSNPs were radiolabeled with gallium-68 ((68)Ga), implementing the chelator tris(hydroxypyridinone). 36 mice were included in the study, 24 mice received a magnetic implant subcutaneously on the left and a titanium implant on the right hind leg. …”
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    Preparation and PET/CT imaging of implant directed (68)Ga-labeled magnetic nanoporous silica nanoparticles
  19. 14239
    “…Moreover, glutelin hydrolysate fraction prepared by Alcalase with a 16.35 ±0.29% hydrolysis degree was selected for further purification because of their high antioxidant activities, including ABTS radical-scavenging activity (0.44–0.55 µmol Trolox eq./g) and metal chelating activity (1721.99–1751.71 µmol EDTA eq./g). …”
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    Isolation and Identification of Antioxidant Peptides Derived from Cricket (Gryllus bimaculatus) Protein Fractions
  20. 14240
    “…Fourier transform infrared spectroscopy (FTIR) results revealed that AMF increased the number and types of functional groups, including −OH/−NH and carboxylate, which chelate Cd in the lignin. Our research shows that AMF can improve the ability of maize plants to tolerate Cd by reducing the amount of Cd transferred from the roots to the shoots. …”
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    The Role of Lignin in the Compartmentalization of Cadmium in Maize Roots Is Enhanced by Mycorrhiza
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