“…Intriguingly, a crucial loop from A4 DBL 3X which provides the important Gly and Lys residues that chelate the bound sulphate is missing or significantly altered in all other DBL domains that interact with CSA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The intensity of the band at 1710 cm(−1) in the control samples decreased drastically after cadmium treatment indicating carbonyl of COOH to be involved in metal chelation. A band at 1224 cm(−1) for untreated P. tetrastromatica (c) and at 1220 cm(−1) for Cd-treated P. tetrastromatica (t) is indicative of the involvement of phosphoryl group in metal binding. …”
Enlace del recurso
Enlace del recurso

“…FSK-stimulated Cl(−) secretion was completely inhibited by the additive effects of the PKA inhibitor, H89 (1 µM), and the [Ca(2+)](i) chelator, 1,2-bis-(o-aminophenoxy)-ethane-N,N,N’,N’-tetraacetic acid, tetraacetoxymethyl ester (BAPTA-AM; 25 µM). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The maximum values of the 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), 3-(2-pyridyl) 5,6-bis(4-phenyl-sulphonic acid)-1,2,4-triazine (ferrozine), radical scavenging activities and metal chelating properties were 86.67%, 91.27% and 82.57%, and 84.67%, 92.60% and 78.00% for FMM and HWD, respectively, with a significant difference (P < 0.05) between the samples. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We show just as in these polymerases, Thg1 possesses an active site with three acidic residues that chelate Mg(++ )cations. Based on this we predict that Thg1 catalyzes polymerization similarly to the 5'-3' polymerases, but uses the incoming 3' OH to attack the 5' triphosphate generated at the end of the elongating polynucleotide. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Recent approaches to stimulate spermatozoa include bicarbonate, metal chelators or platelet-activating factor (PAF). While the use of PAF already resulted in pregnancies in intrauterine insemination, the suitability of the other substances for the clinical use still needs to be tested. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A crystal structure with bound DPBA shows the inhibitor chelating two active site manganese ions. The essential role of this endonuclease in cap-dependent transcription was demonstrated by the loss of transcriptional activity in a RNP reconstitution system in cells upon making the same point mutations in the context of the full-length LACV L-protein. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: The D-galacturonic acid derived from plant pectin can be converted into a variety of other chemicals which have potential use as chelators, clarifiers, preservatives and plastic precursors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: In fibroblasts that lack Psen1 induction of HIF-1α was impaired in response to the hypoxia mimetic cobalt chloride, as well as was induction by insulin and calcium chelation. Reintroduction of human Psen1 using a lentiviral vector partially rescued the responsiveness of Psen1-/- fibroblasts to cobalt chloride induction. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…PGE(2 )levels were detected by an enzyme-linked immunoassay. Hemoglobin (a chelator of carbon monoxide, CO, one of metabolites of HO-1) and CO-RM2 (a CO releasing molecule) were used to investigate the mechanisms of HO-1 regulating COX-2 expression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Isomerisation of Asp1 produced a single dominant species involving a stable 5-membered Cu(2+) chelate at the amino terminus. The Aβ3–16 and Aβ3[pE]–16 peptides both exhibited an equilibrium between two Cu(2+) coordination modes between pH 6–9 with nominally the same first coordination sphere, but with a dramatically different pH dependence arising from differences in H-bonding interactions at the N-terminus. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A simple refolding procedure was developed on HiTrap Chelating column that yielded a refolded DsbA:HIV-1Pr with a > 80% recovery. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Finally we showed that the particle-induced formation of ROS, liberation of AA and PGE(2)/TXB(2 )together with the phosphorylation of ERK1/2 and JNK1/2 proteins was decreased after pre-treatment of macrophages with the metal chelator deferoxamine mesylate (DFO). CONCLUSIONS: These results indicate that one of the primary mechanism initiating inflammatory processes by incinerator fly ash particles seems to be the metal-mediated generation of ROS, which triggers via the MAPK cascade the activation of AA signalling pathway.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Co-treatment with the NQO1 inhibitor, dicoumarol, or the calcium chelator, BAPTA-AM, rescued the erythrocyte-deficiency in circulation and heart-looping defect phenotypes in β-lapachone-treated embryos. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Pre-incubation with the intracellular calcium chelator BAPTA-AM reduced both NRG1- and NRG1/NMDA-stimulated migration, suggesting the involvement of Ca(2+ )in these processes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: Twenty-eight asymptomatic b-thalassemic patients (32.2 ± 4.3 years old, 17 men) who were on iron chelating therapy, as well as 20 age- and sex-matched healthy controls underwent transthoracic RT3DE. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…All chimerae were efficiently secreted from transformed Pichia pastoris yeast except XL3-HSA, and following nickel chelate affinity purification were found to be intact by amino acid sequencing, as was an N-terminally His-tagged version of α(2)AP(13-42)-HSA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The expression product obtained was purified by using Ni chelating affinity chromatography. Recombinant protein of RPL23A obtained from the experiment acted on Hep-2 cells and human HepG-2 cells, then the growth inhibitory effect of these cells was observed by MTT (3-[4,5-dimethyl-2-thiazolyl]-2,5-diphenyl-2H-tetrazolium bromide) assay. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…PURPOSE: Myocardial late gadolinium enhancement was originally validated using higher than label-recommended doses of gadolinium chelate. The objective of this study was to evaluate available evidence for various gadolinium dosing regimens used for CMR. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Either OGD or over-expression of 1B/(−)IRE DMT1 isoform significantly increased iron uptake, as detected by total reflection X-ray fluorescence, and iron-dependent cell death. Iron chelation by deferoxamine treatment or (−)IRE DMT1 RNA silencing displayed significant neuroprotection against OGD which concomitantly decreased intracellular iron levels. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso