“…All antibody administrations included 370 MBq (10 mCi) of (111)In labeled to 2 mg of J591 via the chelating agent DOTA. Three whole body (WB) gamma camera scans with at least one SPECT scan, along with multiple WB count-rate measurements and blood samples, were obtained for all patients. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: The extracts would offer the overall protective effect via counteracting with Cd mediated oxidative stress and/or promoting the elimination of Cd by chelating.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…EDEW and EDE showed significant antioxidant activities with therapeutic potential against hydroxyl and phosphomolybdate radicals, β-carotene bleaching assay and in reducing of iron while moderate to low scavenging abilities were recorded for DPPH, nitric oxide and for iron chelation. During anti-inflammatory activity after 4 h of drug administration the 300 mg/kg body weight dose of EDH (68.660 ± 10.502 %) and EDE (51.384 ± 8.623 %) exhibited strong anti-inflammatory activity and reduced the carrageenan-induced paw edema in rat as compared to standard drug diclofenac sodium (78.823 ± 6.395 %). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Because S(0) is rapidly transferred among these various carriers, its biogeochemical roles in such processes as dehalogenation of organic compounds, chelation of trace metals, and anaerobic microbial metabolism are not determined solely by one ionic or molecular species. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The results highlight the importance of storage proteins in metal ion toxicity-resistance and chelation. Interestingly, the protein sorting and recycling factors Exoc7, Cdc1, Sec23A, and Rab11A contributed to the response as well as the polar distributors of metal-transporters ensuring the directional flow of minerals. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: Presence of metal chelators and phyto-antioxidants within AEEF would offer overall protection through promoting Pb clearance coupled with restoring redox balance.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In (II), the ion pairs are linked through an asymmetric three-centre R (1) (2)(4), N—H⋯O,O′ chelate association. In (I), structure extension is through amine N—H⋯O(carbox­yl) hydrogen bonds between the PABA anions, giving a three-dimensional structure. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…IMPORTANCE Many microbes are able to scavenge iron from their surroundings by producing iron-chelating siderophores. One exception is Mycobacterium avium subsp. paratuberculosis, a fastidious, slow-growing animal pathogen whose growth needs to be supported by exogenous mycobacterial siderophore (mycobactin) in the laboratory. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…JRF/AβN/25 was radiolabeled with a [(89)Zr]-desferal chelate and intravenously injected into 12–13 month aged APPPS1–21 mice and their wild-type (WT) controls. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The inhibitory effect of 100 µmol/l NFA on the GABA-evoked inward current were also strongly inhibited by nitrendipine (NTDP; an L-type calcium channel blocker), 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis (a highly selective calcium chelating reagent), caffeine (a widely available Ca(2+) consuming drug) and calcium-free extracellular fluid, in a concentration-dependent manner. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The effects of high concentrations of WIN on cytokine and MMP-3 production were decreased by the calcium chelating agent BAPTA, the AMPK activator metformin, the TRPA1 antagonist A967079 and the CB(2) antagonist COR170. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Using drug-based lead discovery, we report the concentration threshold-dependent antiretroviral action of the medicinal chelator deferiprone and validate preclinical findings by a proof-of-concept double-blind trial. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Herein, this study reports the development of a Zirconium-89 ((89)Zr)-labeled anti-IGF-1R antibody ((89)Zr-Df-1A2G11) for PET imaging of pancreatic cancer. Successful chelation and radiolabeling of the antibody resulted in a highly stable construct that could be used for imaging IGF-1R expressing tumors in vivo. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Euglena tuba, a microalga, is known for its excellent antioxidant and iron-chelation activities; however its anticancer efficacies have not been reported yet. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…YY146, an anti-CD146 monoclonal antibody, was employed as a targeting molecule to which we conjugated the zwitterionic near-infrared fluorescence (NIRF) dye ZW800-1 and the chelator deferoxamine (Df). This enabled labeling of Df-YY146-ZW800 with (89)Zr and its subsequent detection using PET and NIRF imaging, all without compromising antibody binding properties. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The enzyme activity was inhibited by sulfhydryl agent, chelating agent, and metal ion. The enzyme was highly specific for farnesal and NAD(+). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To facilitate this, we previously developed a biocompatible necrosis-avid near-infrared fluorescence (NIRF) imaging probe, HQ4, which was radiolabeled with (111)Indium-chloride ((111)In-Cl(3)) via the chelate diethylene triamine pentaacetic acid (DTPA), to enable clinical translation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our own recently published data revealed that stabilization of hypoxia-inducible factor 1α (HIF-1α) by the iron chelating HIF-1α-agonist desferoxamine or AKB-4924 enhanced the release of phagocyte extracellular traps. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We also determined the specificity of 2C6F3 to bind tumors in vivo using SPECT/CT imaging. 2C6F3 was conjugated with diethylene triamine penta acetic acid (DTPA) chelator and radiolabeled with (111)Indium ((111)In). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The crucial role of the metals was confirmed by experiments with the metal-chelator bathocuproine disulfonic acid, which showed different inhibitory effects in the signaling cascade, due to different metal affinity of NGF, NGF(1–14) and Ac-NGF(1–14). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso