“…Interestingly, the iron chelator Deferoxamine (DFO) significantly inhibits RSL3/BV6-induced cell death, whereas it is unable to rescue cell death by Erastin/BV6, showing that RSL3/BV6-, but not Erastin/BV6-mediated cell death depends on iron. …”
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“…RESULTS: NaCl-induced NFAT5 gene expression was fully inhibited by calcium chelation and blockers of inositol triphosphate (IP(3)) receptors and phospholipases C and A(2). …”
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“…In addition, the antioxidant activities of the four extracts of D. heterophyllum were measured by DPPH assay, ABTS assay, anti-lipidperoxidation assay, ferric reducing antioxidant power assay, ferrous metal ions chelating assay and determination of total phenolic contents. …”
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“…Chemotaxis was impaired when [Ca(2+)](i)-transients were suppressed by the presence of a Ca(2+)-chelator in the cytosol of the cells. Analysis of ion fluxes revealed that capacitative Ca(2+)-entry was fully operative in the mutant. …”
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“…AtDAPs are highly conserved metallopeptidases activated by MnCl(2) and inhibited by ZnCl(2) and divalent ion chelators. The protease inhibitor PMSF inhibited and DTT stimulated both His(6)-DAP1 and His(6)-DAP2 activities suggesting a role for thiols in the AtDAP catalytic mechanism. …”
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“…One form contains a predicted metal-binding Zn-ribbon that consists of four conserved cysteines (in some cases replaced by histidines), whereas, in the second form, these metal-chelating residues are completely or partially replaced. …”
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“…Cambridge, MA) were labeled with (64)CuCl(2) chelated with 4-DEAP-ATSC. Tumor-bearing mice received ~200-300 μCi of (64)Cu-MM-DX-929 and imaged with microPET. …”
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“…To investigate whether biological functions are reflected in molecular properties, we compare aspects of zinc(II)-binding dynamics of full-length MT4a and MT4b, namely the pH dependence of zinc(II) binding and protein folding, and zinc(II) transfer to the chelator EDTA. UV–Vis and NMR spectroscopies as well as native electrospray ionisation mass spectrometry consistently showed that transfer from Zn(6)MT4a is considerably faster than from Zn(6)MT4b, with pseudo-first-order rate constants for the fastest observed step of k (obs) = 2.8 × 10(−4) s(−1) (MT4b) and k (obs) = 7.5 × 10(−4) s(−1) (MT4a) (5 µM protein, 500 µM EDTA, 25 mM Tris buffer, pH 7.33, 298 K). 2D heteronuclear NMR experiments allowed locating the most labile zinc(II) ions in domain II for both proteins. 3D homology models suggest that reactivity of this domain is governed by the local environment around the mononuclear Cys(2)His(2) site that is unique to type 4 MTs. …”
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“…However, calcium was not necessary for serotonergic excitation, as responses to 5-HT were enhanced (by >100%), rather than reduced, by chelation of intracellular calcium with 10 mM BAPTA. …”
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“…In case of KCl exposure, Ca(2)+-free buffer with the calcium chelator, ethylenediaminetetracetic acid (EDTA), could suppress the tracer washout from PC12 cells. …”
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“…Methods: A monomeric bifunctional ligand with a fibrin-specific peptide, a short spacer, and (99m)Tc chelating amino acid sequence (F1A) was developed and compared to its tetrameric PEG analogue (F4A). …”
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“…Conjugates of bisphosphonates with macrocyclic chelators open new possibilities in bone targeted radionuclide imaging and therapy. …”
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“…A murine IgG(1), A7, against a 45 kD glycoprotein in human colon cancer was radiolabeled with (186)Re by using a chelating method with a mercaptoacetyltriglycine (MAG3). (186)Re‐MAG3 complex was conjugated to A7 after esterification of (186)Re‐MAG3 with tetrafluorophenol (TFP). …”
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“…In two of the new species, the shape of the gills, length/width of exopod of maxilliped 3, width and shape of sternite XI (of pereopods 3), and armature of the dactyls and fixed fingers of the chelate pereopods 4, were found to be characters so markedly different from P. typica and other species discovered that a new genus for them, Paguropsina gen. n., is justified. …”
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“…In order to correlate the results obtained by amperometric and spectrophotometric measurements, CD experiments have been performed showing a great structural change of FDH when increasing the concentration CaCl(2) up to 50 mM, at which the enzyme molecules start to agglomerate, hindering the substrate access to the active site probably due to a chelation reaction occurring at the enzyme surface with the glutamate/aspartate residues. …”
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“…Deletion of C. albicans ZRT2 reduced kidney fungal burden in wild type, but not in mice lacking the zinc-chelating antimicrobial protein calprotectin. Inhibition of zrt2Δ growth by neutrophil extracellular traps was calprotectin-dependent. …”
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“…The pre-erosion of CS can expose more phenolic compounds that were chelated to oxidized Mn(3+) and also provided mediators for combination with laccase, which was attributable to B-6 pretreatment. …”
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“…The increased cytosolic Ca(2+) then bound to calmodulin to activate calcium/calmodulin-dependent protein kinase II (CaMKII) signaling, leading to mitochondrial apoptosis pathway activation. Ca(2+) chelator BAPTA partially reversed curcumin-induced ER stress and growth suppression, confirming the possible involvement of calcium homeostasis disruption in this response. …”
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“…ZMCs are small molecule metal ion chelators that bind zinc and other divalent metal ions strong enough to remove zinc from serum albumin, but weak enough to donate it to mutant p53. …”
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“…Here, we describe a novel exendin-3-based radiotracer with multiple chelators and determine its potential for in vivo beta cell imaging. …”
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