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  1. 14661
    “…Similarly, in the FRAP assay, the same pattern of the activity was observed with ROE and ROEA, which displayed absorbance values of 1.32 ± 0.01 and 0.80 ± 0.02 at 700 nm, respectively, which are comparable (1.76 ± 0.02) with the reference compound quercetin, whereas the ROH showed maximum metal-chelating capacity (62.61% ± 1.01%) among all extracts and fractions. …”
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    Phytochemical profiling, in vitro biological activity, docking studies, and cytotoxicity assessments of Rondeletia odorata Jacquin: An unexplored plant of the coffee family
  2. 14662
    “…Bacterial sequence database such as PATRIC is a useful tool for tracking the existence and emergence of AMR genes. DISCLOSURES: Chetan Jinadatha, MD, MPH, AHRQ R01 Grant-5R01HS025598: Grant/Research Support|EOS Surfaces: Copper Coupons and materials for testing.…”
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    136. Prevalence of Plasmid-Mediated Antibiotics Resistance Genes in Klebsiella pneumoniae in United States
  3. 14663
    “…Here, we use strong chelators (2Z-6Z)-piperidine-2,6-dione (H(3)pidiox) and 2,3-dihydroxybenzaldehyde oxime (H(3)dihybo) to synthesize the first ever reported pentanuclear {Hf(5)/H(3)pidiox} and hexanuclear {Hf(6)/H(3)dihybo} clusters (HfOCs). …”
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    Hafnium(IV) Chemistry with Imide–Dioxime and Catecholate–Oxime Ligands: Unique {Hf(5)} and Metalloaromatic {Hf(6)}–Oxo Clusters Exhibiting Fluorescence
  4. 14664
    “…The observed findings revealed that the activity enhances coordination as compared to free ligand via Overtone’s and Tweedy’s chelation mechanisms. This is especially encouraging given that in every case, the experimental findings and theoretical detections were in perfect accord.…”
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    An Integrated Analysis of Mechanistic Insights into Biomolecular Interactions and Molecular Dynamics of Bio-Inspired Cu(II) and Zn(II) Complexes towards DNA/BSA/SARS-CoV-2 3CL(pro) by Molecular Docking-Based Virtual Screening and FRET Detection
  5. 14665
    “…Mechanically, relatively abundant GLIS2 and histone deacetylase 3 (HDAC3) form chelates to avoid the deacetylation of PPAR-γ, so as to maintain the activation level of PPAR-γ signaling pathway in HSCs cells. …”
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    GLIS2 Prevents Hepatic Fibrosis by Competitively Binding HDAC3 to Inhibit Hepatic Stellate Cell Activation
  6. 14666
    “…However, there is limited information regarding the role of MCFAs chelated with Zn in diarrhea induced by ETEC infection. …”
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    Zinc Laurate Protects against Intestinal Barrier Dysfunction and Inflammation Induced by ETEC in a Mice Model
  7. 14667
    “…A personalized approach to treating thalassemia patients (transfusions, iron chelation, and splenectomy), has increased patients’ life expectancy, however they generally present many complications and several studies have demonstrated the presence of high incidence of thromboembolic events. …”
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    Hemorheological profiles and chronic inflammation markers in transfusion-dependent and non-transfusion- dependent thalassemia
  8. 14668
    “…Finally, changing the chelating phosphine to Cy(2)PCH(2)CH(2)PCy(2) results in initial high polarization efficiencies for propene hydrogenation, but rapid quenching of the catalyst competes to form the zwitterion [Rh(Cy(2)PCH(2)CH(2)PCy(2)){η(6)-(CF(3))(2)(C(6)H(3))}BAr(F)(3)].…”
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    Mechanistic Insights into Molecular Crystalline Organometallic Heterogeneous Catalysis through Parahydrogen-Based Nuclear Magnetic Resonance Studies
  9. 14669
    “…Besides, the expression of PDXK was upregulated after the induction of cuproptosis by elesclomol–CuCL(2), which could be suppressed when pretreated with a copper ion chelator. And PDXK deficiency increased the sensitivity of HCC cells to cuproptosis inducer. …”
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    Identification of a prognostic cuproptosis-related signature in hepatocellular carcinoma
  10. 14670
    “…The β-defensin human β-defensin 1 (HBD-1) inhibited hemolysin but not superantigen production. The cation chelator S100A8/A9 (calprotectin), compared to EDTA, was tested for the ability to inhibit exotoxin production. …”
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    Host Cationic Antimicrobial Molecules Inhibit S. aureus Exotoxin Production
  11. 14671
    “…Specifically, we explore the impacts of chloride-based salts, a strong chelating agent, elevated temperature, and sonication on the rate and extent of contaminant corrosion, while concurrently evaluating the effects on NMC. …”
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    Optimized purification methods for metallic contaminant removal from directly recycled Li-ion battery cathodes
  12. 14672
    “…The present research investigates the relative bioavailability, antioxidant, and ability to inhibit inflammatory cytokine production of a curcuminoid metal chelation complex of tetrahydrocurcumin-zinc-curcuminoid termed TurmiZn. …”
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    Efficacy of TurmiZn, a Metallic Complex of Curcuminoids-Tetrahydrocurcumin and Zinc on Bioavailability, Antioxidant, and Cytokine Modulation Capability
  13. 14673
    “…The T-SMPDC is built upon a triazine core (TZ) to present three functionalities: (1) a chelating moiety (DOTA: 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) for PET imaging when labeled with (68)Ga (t(1/2) = 68 min) or other relevant radiometals; (2) an octreotide (Octr) that targets the somatostatin receptor 2 (SSTR2), which is overexpressed in the innervated tumor microenvironment (TME); and (3) fingolimod, FTY720—an antagonist of sphingosine kinase 1 that is an intracellular enzyme upregulated in NEPC. …”
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    A Theranostic Small-Molecule Prodrug Conjugate for Neuroendocrine Prostate Cancer
  14. 14674
    “…Few preventive interventions aiming to increase resilience in the face of adversity have been rigorously evaluated among Chilean preschoolers. Substantial international evidence indicates that strengthening basic psychological skills, such as emotion regulation and social problem-solving, can reduce the incidence of mental pathology and improve various academic indicators. …”
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    Mental Health Prevention in Preschool Children: study protocol for a feasibility and acceptability randomised controlled trial of a culturally adapted version of the I Can Problem Solve (ICPS) Programme in Chile
  15. 14675
    “…We conclude that, under the current Chilean standards for the long-distance transport, the welfare of the livestock is adversely affected. …”
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    Physiological and Behavioural Responses of Cattle to High and Low Space, Feed and Water Allowances During Long Distance Transport in the South of Chile
  16. 14676
    “…Here, we describe the neutralizing capacities of antibodies secreted by volunteers in the Chilean population immunized with CoronaVac against variants of concern Alpha (B.1.1.7), Beta (B.1.351) Gamma (P.1) and Delta (B.617.2). …”
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    Recognition of Variants of Concern by Antibodies and T Cells Induced by a SARS-CoV-2 Inactivated Vaccine
  17. 14677
    por Fonslet, Jesper
    Publicado 2019
    “…The work performed using therapeutic isotopes includes: 177Lu: The sensitive metalloprotein FVIIai was conjugated with the chelator cDTPA and labeled with 177Lu for a therapeutic study. …”
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    Production and utilization of unconventional radiometals for advanced diagnostics and therapy
  18. 14678
    por Van den Bergh, Viktor
    Publicado 2022
    “…In these, radionuclides are chelated to vector molecules, designed to bind with cancer cells. …”
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    Towards Alpha Dosimetry with Laser Ionized and Mass Separated 225Ac: Setup Development and Source Characterization
  19. 14679
    “…Importantly, the HBED-CC chelator enabled (67)Ga-labeling at high molar activity, which would be essential to obtain images with high signal-to-background contrast to detect (patho)physiological ACE2 expression levels in patients. …”
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    A tool for nuclear imaging of the SARS-CoV-2 entry receptor: molecular model and preclinical development of ACE2-selective radiopeptides
  20. 14680
    “…RESULTS: An anti-CD70 VHH construct containing a C-direct-tag with a free thiol was developed to enable site-specific conjugation to a NOTA bifunctional chelator for (68)Ga radiolabeling. [(68)Ga]Ga-NOTA-anti-CD70 VHH was obtained in good radiochemical yield of 30.4 ± 1.7% and high radiochemical purity (> 94%). …”
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    Site-specific (68)Ga-labeled nanobody for PET imaging of CD70 expression in preclinical tumor models
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