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  1. 14681
    “…Both DFO-modified immunoconjugates retained their affinity for Gal-3BP in enzyme-linked immunosorbent assay experiments. The chelator-bearing antibodies were radiolabeled with zirconium-89 (t(1/2) ≈ 3.3 d) to produce radioimmunoconjugates — [(89)Zr]Zr-DFO-1959 and [(89)Zr]Zr-DFO-1959-sss/DM4 — with high specific activity (>444 MBq/mg, >12 mCi/mg) and stability (>80% intact after 168 h in human serum at 37 °C). …”
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    Visualizing Galectin-3 Binding Protein Expression with ImmunoPET
  2. 14682
    “…In this study, we developed a FAP targeting ligand, LuFL, containing organosilicon-based fluoride acceptor (SiFA) and DOTAGA chelator, capable of labeling fluorine-18 and lutetium-177 in one molecular with simple and highly efficient labeling procedure, to achieve cancer theranostics. …”
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    A radiohybrid theranostics ligand labeled with fluorine-18 and lutetium-177 for fibroblast activation protein-targeted imaging and radionuclide therapy
  3. 14683
    “…The in vitro antioxidant potential of SsBu was assessed by DPPH (175.5 ± 7.35 mg TE/g), ABTS (391.6 ± 17.1 mg TE/g), FRAP (418.2 ± 10.8 mg TE/g), CUPRAC (884.8 ± 7.97 mg TE/g), phosphomolybdenum (5.7 ± 0.33 mmol TE/g), and metal chelating activity (9.04 ± 0.58 mg EDTAE/g). Moreover, in the in vitro studies, inhibition (%) of egg albumin and bovine serum albumin denaturation assays showed that the anti-inflammatory effect of SsBu at the dose of 800 μg/ml was comparable to that of diclofenac sodium used as a standard drug. …”
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    Antiarthritic potential of the butanol fraction of Sesuvium sesuvioides: An in vitro, in vivo, and in silico evaluation
  4. 14684
    “…Catalase activity decreased in cells treated with palladium chelate. The DPPH radical scavenging assay results identified that complex one was a more potent antioxidant in MCF-7 and Hela cells than other complexes with SC(50) values of 227.5 ± 0.28 and 361 ± 1.2 μL/mL, respectively. …”
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    Study of novel bidentate heterocyclic amine-based metal complexes and their biological activities: cytotoxicity and antimicrobial activity evaluation
  5. 14685
    “…For nonchelating oxetane substrates, electrostatic interactions with the catalyst confer stereoselectivity, whereas oxetanes with chelating groups adopt a different binding mode that leads to electrostatic effects that erode selectivity. …”
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    Electrostatic Interactions in Asymmetric Organocatalysis
  6. 14686
    “…Analysis of the recombinant enzyme expressed in E. coli and purified by immobilized metal chelate affinity chromatography (IMAC) showed an optimal lysis activity against various LAB species at pH 6, with stability from pH 4 to 8 and from 20 to 40 °C up to 48 h. …”
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    Novel endolysin LysMP for control of Limosilactobacillus fermentum contamination in small-scale corn mash fermentation
  7. 14687
    “…In this case report, the chelation of calcium by citrate masked the immobilization hypercalcemia, resulting in marked bone loss and spontaneous vertebral fractures in the context of normal calcium levels. …”
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    THU433 Spontaneous Vertebral Fractures In The Setting Of Prolonged CRRT
  8. 14688
    “…The addition of the antioxidant L-methionine and chelating agent disodium EDTA improved the formulation's long-term colloidal and thermal stability. …”
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    SAT669 Development And Biophysical Characterization Of A Humanized FSH-blocking Monoclonal Antibody Therapeutic Formulated At An Ultra-high Concentration
  9. 14689
    “…In contrast to previously published data on in vivo generators based on chelators, where the daughter radionuclide diffuses away from the molecules, daughter radionuclide (109m)Ag remains on the surface of gold nanoparticles after the decay of (109)Pd. …”
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    Au@(109)Pd core–shell nanoparticle conjugated to trastuzumab for the therapy of HER2+ cancers: studies on the applicability of (109)Pd/(109m)Ag in vivo generator in combined β(−) auger electron therapy
  10. 14690
    “…Western blots and electron microscopy demonstrated that CS14 expression required the growth of isolates on CFA agar with the iron chelator deferoxamine mesylate. CS14 expression resulted in significantly increased adherence to cultured intestinal cells and human enteroids. …”
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    The role of the minor colonization factor CS14 in adherence to intestinal cell models by geographically diverse ETEC isolates
  11. 14691
    “…PROCEDURES: Two MADs, 8.7 kDa and 22.6 kDa modified with DOTA chelators, were synthesized and radiolabeled with (68)Ga. …”
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    In vivo Assessment of the Impact of Molecular Weight on Constructs of (68)Ga-DOTA-Manocept in a Syngeneic Mouse Tumor Model
  12. 14692
    “…METHODS: Isolated rat type II pneumocytes were incubated with C. pneumoniae after pre-treatment with calcium chelator BAPTA-AM, inhibitors of NF-κB (parthenolide, SN50) or with a specific inhibitor of the Rho-GTPase (mevastatin). …”
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    Chlamydophila pneumoniae induces expression of Toll-like Receptor 4 and release of TNF-α and MIP-2 via an NF-κB pathway in rat type II pneumocytes
  13. 14693
    “…In the second test, the ability of PGF2alpha to inhibit LH-stimulated P4 secretion in Day-10 luteal cells was examined under conditions in which an elevation in [Ca(2+)]i had been buffered by means of the intracellular calcium chelator, Bapta-AM. PKCepsilon expression was reduced 65 and 75% by 72 and 96 h after transfection, respectively. …”
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    PKCepsilon and an increase in intracellular calcium concentration are necessary for PGF2alpha to inhibit LH-stimulated progesterone secretion in cultured bovine steroidogenic luteal cells
  14. 14694
    Publicado 1979
    “…Although the regulatory proteins present in normal serum chelated with EDTA or presented as a combination of purified C3bINA and beta 1H were relatively inefficient in inactivating C3b function on an activating particle of the alternative pathway such as zymosan or zymosan-cyanogen bromide, the control proteins rapidly inactivated C3b on a nonactivating particle wuch as a sheep erythrocyte or zymosan with coupled heparin. …”
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    Surface-associated heparin inhibits zymosan-induced activation of the human alternative complement pathway by augmenting the regulatory action of the control proteins on particle-bound C3b
  15. 14695
    Publicado 1996
    “…We show that ER overload-mediated NF-kappaB activation but not TNF-stimulated NF-kappaB induction can be inhibited by the intracellular Ca2+ chelator TMB-8. Moreover, treatment of cells with two inhibitors of the ER-resident Ca(2+) -dependent ATPase, thapsigargin and cyclopiazonic acid, which causes a rapid release of Ca2+ from the ER, strongly activated NF-kappaB. …”
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    Activation of transcription factor NF-kappaB by the adenovirus E3/19K protein requires its ER retention
  16. 14696
    Publicado 1989
    “…We have studied calcium-activated potassium current, IK(Ca), and calcium-activated nonspecific cation current, INS(Ca), in Aplysia bursting pacemaker neurons, using photolysis of a calcium chelator (nitr-5 or nitr-7) to release "caged calcium" intracellularly. …”
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    "Caged calcium" in Aplysia pacemaker neurons. Characterization of calcium-activated potassium and nonspecific cation currents
  17. 14697
    “…Similar to NCX1, expression of NCX-SQ1 in Xenopus oocytes induced cytoplasmic Na(+)-dependent (45)Ca(2+) uptake; the uptake was inhibited by injection of Ca(2+) chelators. In giant excised membrane patches, the NCX-SQ1 outward exchange current showed Na(+)-dependent inactivation, secondary activation by cytoplasmic Ca(2+), and activation by chymotrypsin. …”
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    Cloning, Expression, and Characterization of the Squid Na(+)–Ca(2+) Exchanger (NCX-SQ1)
  18. 14698
    Publicado 1993
    “…At 20 mM it increased several-fold the open probability of channels from purified RyR incorporated in planar bilayers and conducting Ba2+, an effect seen on channels first closed by chelation of Ca2+ or by the presence of Mg2+. It significantly increased the initial rate of efflux of 45Ca2+ from TR vesicles (by a factor of 1.75 at 20 mM and 4.5 at 100 mM). …”
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    Effects of perchlorate on the molecules of excitation-contraction coupling of skeletal and cardiac muscle
  19. 14699
    “…However, blockage of L-type Ca(2+ )channels or calcium/calmodulin-dependent protein kinase II, chelating extracellular Ca(2+ )or emptying internal Ca(2+ )stores, did not affect ET-1-induced activation of ERK1/2. …”
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    Role of ERK/MAPK in endothelin receptor signaling in human aortic smooth muscle cells
  20. 14700
    “…Xoo produces a range of virulence factors, including EPS, extracellular enzyme, iron-chelating siderophores, and type III-secretion dependent effectors, which are collectively essential for virulence. …”
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    Rice bacterial blight pathogen Xanthomonas oryzae pv. oryzae produces multiple DSF-family signals in regulation of virulence factor production
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