“…It was revealed that there were three major mechanisms involved in MT-mediated Cd detoxification in cotton, including the enhancement of antioxidant capacity regulated by APX, flavonoids and alkaloids; accumulation of secondary metabolites related to Cd chelation, such as amino acids and derivatives; and regulation of cadmium ion transportation, such as ABC transporter activation. …”
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“…In addition, isolates carried bla(SHV−106) (100%), bla(KPC−2) (69%), bla(CTX−M−15) (69%), bla(TEM−1B) (69%), bla(OXA−1) (62%) and bla(LAP−2) (8%), as well as iron chelators (iutA, ybt, fyuA, ent, fepA, irp1, irp2, 100%) were detected. …”
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“…DISCLOSURES: Piyali Chatterjee, PhD, AHRQ Grant # 1R03HS027667-01: Grant/Research Support|AHRQ Grant # 1R03HS027667-01: Central Texas Veterans Health Care System Chetan Jinadatha, MD, MPH, AHRQ R01 Grant-5R01HS025598: Grant/Research Support|EOS Surfaces: Copper Coupons and materials for testing.…”
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“…Our recommended interventions include intermittent-or-continuous calorie restriction or fasting[PMID: 33138875, PMC9351392, PMC7956384], protein- and/or methionine-restriction[PMC9197402, PMC4023024, PMC9197406], consumption of moderately-strong metal chelators (e.g. polyphenols in blueberries[PMC1413581], other berries[PMC8271923], grapes[PMC7096489, PMC6386230], cherries[PMC8745076], fruits with hesperidin/hesperitin [PMC9310407] like oranges, soybeans with genistein [PMC4286753], ginger [PMC5852742], ginseng [PMC9358063, PMC3830124, PMC6874434], green/rooibos/oolong teas[PMC6567241, PMIDs: 33285593, 19996359], coffee[PMC4926853, PMC9145055], chocolate[PMC9287426]), antioxidant-rich foods[PMC7530501], B vitamins including vitamin B5 (pantothenic acid[PMC9232186, PMC8725342, https://doi.org/10.3181%2F00379727-99-24442]) to help metabolize partly-toxic aldehydes[PMC6802361] and improve/lower lactate/pyruvate and NAD+/NADH ratios[PMC7346061], ingesting adequate-to-high amounts of longevity-correlated tyrosine[PMC6681387], cysteine[PMID: 20191258], glutathione[PMC8912885, PMC5005830], niacin, nicotine acid and/or NADH[PMC7346061, PMC6982340], spermidine[PMC8436989], anti-inflammatory NSAIDS[PMC4270464], autophagy inducers[PMC6191153] fiber[PMC8705837] and fluids[PMID: 21585170] to help remove excess metals, toxic metabolites and damaged organelles, while limiting methionine-rich, other pro-aging foods[PMC4023024].…”
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“…Here, we designed and synthesized two heterobivalent radioligands consisting of the EGFR-specific peptide GE11 and α(v)β(3)-specific cyclic RGD peptides, bearing a (1,4,7-triazacyclononane-4,7-diyl)diacetic acid-1-glutaric acid chelator for efficient radiolabeling and linkers of different lengths between both peptides. …”
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“…However, the blockage of the TRPC6 Ca(++) channel or the use of Ca(++) and Zn(++) chelators do not hinder HPF cytostatic/cytotoxic activity, suggesting that damages induced in melanoma cells may pass through other pathways. …”
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“…Univariate analyses showed that interruption of iron chelation treatment significantly affected HSU values (P = 0.038); diagnosis with comorbidity very slightly affected HSU values (P = 0.0996). …”
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“…The propensity of 4-hydroxybenzhydrazone-related ligands derived from 3-methoxysalicylaldehyde (H(2)L(3OMe)), 4-methoxysalicylaldehyde (H(2)L(4OMe)), and salicylaldehyde (H(2)L(H)) to act as chelating and/or bridging ligands in Ni(II) complexes was investigated. …”
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“…ABSTRACT: Red blood cell (RBC) transfusion is associated with recipient inflammation and infection, which may be triggered by excessive circulating iron. Iron chelation following transfusion may reduce these risks. …”
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“…Chile, with wide dissemination of the CC5 Chilean-Cordobes clone, has high MRSA rates. In 2019, CLSI revised the breakpoints (BPs) keeping susceptible (S, minimum inhibitory concentration [MIC mg/L] ≤1), added susceptible dose-dependent (SDD, MIC 2–4), removed intermediate (MIC 2); resistant (R) is now MIC ≥8. …”
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“…Herein, we sought to determine the influence of SNPs on CYP3A5, MRP2 and UGT1A9 genes in Chilean pediatric kidney recipients using TAC and MPA. …”
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“…Immunoreactivity was substantially preserved, and more than 75% of (177)Lu remained chelated after 7 d in serum. [(177)Lu]Lu-ofatumumab specifically killed Raji-luc cells in vitro (P < 0.05). …”
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“…Both the iron provided by FeCl(3) and the iron chelated by deferoxamine (DFO) with CoPP treatment failed to affect PCV3 replication. …”
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“…The comprehensive antioxidant potential of the synthesized compounds has been evaluated by determining their free radical scavenging activity, including DPPH, OH, nitric oxide (NO), and iron chelation assay. The derivative Ox-6f showed promising results with 80.23% radical scavenging potential at a dose of 100 µg/mL while ascorbic acid exhibited 87.72% inhibition at the same dose. …”
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“…Treatment of 231-vect cells with a zinc ionophore also increased migration, whereas migration of 231-ZIP9 cells was attenuated by treatment with an intracellular zinc chelator, TPEN. Expression of the migration markers, MYL9 and CYR61, was increased in 231-ZIP9 after 24-48 hr culture, whereas expression of apoptotic markers was decreased compared to 231-vect controls. …”
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“…Common buffers used in biochemical research, such as Tris (hydroxymethyl) aminomethane hydrochloride (Tris-HCl), can chelate metal ions and may thus affect the activity of metalloenzymes, which are enzymes that require metal ions for enhanced catalysis. …”
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“…The results reveal that the size of the chelating ligand and the pyrazolyl donor angle of the ditopic ligand play crucial roles in determining the resulting solid-state metallacyclic architecture in these synthetic combinations. …”
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“…The catalytic activity of the Pye3 was strongly inhibited by Hg(2+), Ag(+), ρ-chloromercuribenzoate, whereas less pronounced effect was observed in the presence of divalent cations, the chelating agent EDTA and phenanthroline. CONCLUSION: A novel pyrethroid-hydrolyzing esterase gene was successfully cloned using metagenomic DNA combined with activity-based functional screening from soil, the broader substrate specificities and higher activity of the pyrethroid-hydrolyzing esterase (Pye3) make it an ideal candidate for in situ for detoxification of pyrethroids where they cause environmental contamination problems. …”
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“…These results suggest that cyclic light maintenance, Zn(2+) chelation, pyruvate, and nicotinamide promote RPE and photoreceptor survival after injury and could be effective for various forms of retinal neurodegeneration. …”
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“…Formation of cell-cell junctions was tested by treatment with the calcium chelator, EGTA. A second microarray analysis compared gene expression between UCB MSCs grown in LECBM and LECCM to identify changes induced by the lens epithelial cell-conditioned culture medium. …”
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