“…RESULTS: Fusion protein TfRscFv-GAL4 was expressed in an E. coli bacterial expression system and was recovered from inclusion bodies with subsequent purification by metal-chelate chromatography. The resulting proteins were predominantly monomeric and, upon refolding, became a soluble biologically active bifunctional protein. …”
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“…In most instances, additives are essential in controlling the rate of reduction and the chemo- or stereoselectivity of reactions.(13-14) Additives commonly utilized to fine tune the reactivity of SmI(2) can be classified into three major groups: (1) Lewis bases (HMPA, other electron-donor ligands, chelating ethers, etc.), (2) proton sources (alcohols, water etc.), and (3) inorganic additives (Ni(acac)(2), FeCl(3), etc).(3) Understanding the mechanism of SmI(2) reactions and the role of the additives enables utilization of the full potential of the reagent in organic synthesis. …”
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“…Compared with the scenario in healthy subjects, standard 2-hour spacing of calcium formulations and oral LVX was insufficient to prevent a chelation interaction in cystic fibrosis patients. …”
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“…Cystine knot peptide, S(0)2, was first conjugated with a single amino acid chelate (SAAC) and labeled with [(99m)Tc(H(2)O)(3)(CO)(3)](+). …”
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“…In the structure of solvatomorphic compound (I), the symmetry-related irregular ErO(8) coordination polyhedra in the discrete centrosymmetric dinuclear complex comprise two monodentate water mol­ecules and six carboxyl­ate O-atom donors, four from two bidentate carboxyl­ate O,O′-chelate groups and two from the bis-monodentate O:O′-bridging group of the third 4-ABA anion. …”
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“…Methanol fraction displayed higher (P < 0.05) 1,1-diphenyl-2-picryl-hydrazyl (0.47 mg/mL), 2,2-azino-bis (3-ethylbenzothiazoline)-6-sulfonic acid (0.49 mg/mL), and hydroxyl radical (0.55 mg/mL) scavenging activities, while ethyl acetate exhibited strong metal chelating (0.61 mg/mL) and superoxide anion (1.68 mg/mL) scavenging activity. …”
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“…BAPTA-AM, a [Ca(2+)](i) chelator, could reduce the elevation of cleaved caspase-3 and increased apoptotic cells rate due to glycolysis inhibition. …”
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“…Anti- oxidant activities of the extracts were determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, ferric reducing antioxidant power (FRAP), ferrous ion chelation (FIC) and oxygen radical absorbance capacity (ORAC) assays. …”
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“…In vitro molecular biology studies have shown that the addition of EDTA in the combination helps to prevent horizontal gene transfer during conjugation by chelating the divalent magnesium ions (Mg(2+)) required for the activity of DNA relaxases enzyme. …”
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“…One group received macrocylic gadolinium chelate intraperitoneal (IP) and iodine intravenous (IV) injections (protocol A, n = 3), whereas the second group received iodine IP and gadolinium IV (protocol B, n = 3). …”
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“…METHODS: Four novel Glu-urea-based ligands containing the chelators p-SCN-Bn-TCMC or DO3AM were synthesized. …”
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“…MLCK knockdown or inhibition, or Ca(2+) chelation with EGTA, had no effect on serum-induced LC(20) phosphorylation. …”
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“…Novel compounds of interest include chitosan obtained by the deacetylation of chitin, with beneficial properties such as biocompatibility, biodegradability, non-toxicity, and chelation of metal ions. This compound has shown its potential to modify the rumen microbiome, improve nitrogen (N) metabolism, and mitigate enteric methane (CH(4)) under some circumstances. …”
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“…Rationale: The overwhelming majority of radioimmunoconjugates are produced via random conjugation methods predicated on attaching bifunctional chelators to the lysines of antibodies. However, this approach inevitably produces poorly defined and heterogeneous immunoconjugates because antibodies have several lysines distributed throughout their structure. …”
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“…DISCLOSURES: Mark Stibich, n/a, Xenex Germ-Zapping Robots (Board Member, Grant/Research Support) Chetan Jinadatha, MD, MPH, AHRQ (Research Grant or Support)Department of Veterans Affairs (Other Financial or Material Support, Owner: Department of Veterans Affairs. …”
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“…DISCLOSURES: Sarah Simmons, DrPH, Xenex Disinfection Services (Employee, Shareholder) Mark Stibich, PhD MHS, Xenex Disinfection Services, Inc (Board Member, Employee) Chetan Jinadatha, MD, MPH, AHRQ (Research Grant or Support)Department of Veterans Affairs (Other Financial or Material Support, Owner: Department of Veterans Affairs. …”
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“…DTS has the potential to continuously record & report data related of disinfection events on PME in healthcare settings. DISCLOSURES: Chetan Jinadatha, MD, MPH, AHRQ (Research Grant or Support)Department of Veterans Affairs (Other Financial or Material Support, Owner: Department of Veterans Affairs. …”
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“…We conjugated 8709-scFv-Fc with the deferoxamine (DFO) chelator and radiolabeled the DFO-8970-scFv with (89)Zr. …”
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“…SARTATE consists of octreotate, which targets the SSTR2 receptor, conjugated to MeCOSar, a bifunctional chelator with high affinity for copper. Cu-SARTATE offers the potential to both detect and treat neuroblastoma MRD by using [(64)Cu]Cu-SARTATE to detect and monitor the disease and [(67)Cu]Cu-SARTATE as the companion therapeutic agent. …”
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“…In vitro antioxidant potentials were also demonstrated in different assays (DPPH: 6.89–193.93 mg TE/g, ABTS: 20.20–255.39 mg TE/g, CUPRAC: 21.07–333.30 mg TE/g, FRAP: 14.02–168.93 mg TE/g, metal chelating activity: 3.21–17.51 mg EDTAE/g and phosphomolybdenum assay: 1.76–3.55 mmol TE/g). …”
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