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1541“…This article outlines evidence that advanced glycation end product (AGE) inhibitors and breakers act primarily as chelators, inhibiting metal-catalyzed oxidation reactions that catalyze AGE formation. …”
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1542“…BACKGROUND: Effective transfusion and chelation have prolonged the quality and longevity of life in thalassemics, who now survive into adulthood. …”
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1543por Verhoeven, Willem MA, Egger, Jos IM, Willemsen, Marjolein H, de Leijer, Gert JM, Kleefstra, Tjitske“…The 22q13.3 deletion, or Phelan-McDermid syndrome, is characterized by global intellectual disability, generalized hypotonia, severely delayed or absent speech associated with features of autism spectrum disorder, and minor dysmorphisms. …”
Publicado 2012
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1544
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1545por Ceccom, Johnatan, Coslédan, Frédéric, Halley, Hélène, Francès, Bernard, Lassalle, Jean Michel, Meunier, Bernard“…Here we report the capacity of a new copper-specific chelating agent, a bis-8-aminoquinoline PA1637, to fully reverse the deficit of episodic memory after three weeks of treatment by oral route on non-transgenic amyloid-impaired mice. …”
Publicado 2012
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1546por Crumling, Mark A., Liu, Liqian, Thomas, Paul V., Benson, Jennifer, Kanicki, Ariane, Kabara, Lisa, Hälsey, Karin, Dolan, David, Duncan, R. KeithEnlace del recurso
Publicado 2012
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1547“…The purpose of the study is to evaluate the relationship between the extraction parameters and the metal chelating activity of Centella asiatica (CA) and Erythroxylum cuneatum (EC). …”
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1548
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1549
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1550por Castelletto, V., Hamley, I. W., Segarra-Maset, M. D., Gumbau, C. Berdugo, Miravet, J. F., Escuder, B., Seitsonen, J., Ruokolainen, J.“…[Image: see text] We examine the self-assembly of a peptide A(6)H comprising a hexa-alanine sequence A(6) with a histidine (H) “head group”, which chelates Zn(2+) cations. We study the self-assembly of A(6)H and binding of Zn(2+) ions in ZnCl(2) solutions, under acidic and neutral conditions. …”
Publicado 2013
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1551por Nygaard, Sanne Bjørn, Larsen, Agnete, Knuhtsen, Astrid, Rungby, Jørgen, Smidt, Kamille“…Insulin content was reduced by zinc chelation with N,N,N’,N-tektrakis(2-pyridylmethyl)-ethylenediamine. …”
Publicado 2014
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1552“…In the present investigation the chelation of Ca(2+) by the (NANPNVDP)(3)NANP peptide, which contains the first seven 4-amino-acid blocks of the repeat region of the P. falciparum circumsporozoite protein, is tested with the use of circular dichroism and nuclear magnetic resonance spectroscopies. …”
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1553por Zhang, Shaoping, Liu, Hong, Amarsingh, Greeshma V, Cheung, Carlos C H, Hogl, Sebastian, Narayanan, Umayal, Zhang, Lin, McHarg, Selina, Xu, Jingshu, Gong, Deming, Kennedy, John, Barry, Bernard, Choong, Yee Soon, Phillips, Anthony R J, Cooper, Garth J S“…The present study sought to determine how myocardial copper status and key copper-proteins might become impaired by diabetes, and how they respond to treatment with the Cu (II)-selective chelator triethylenetetramine (TETA) in DCM. METHODS: Experiments were performed in Wistar rats with streptozotocin (STZ)-induced diabetes with or without TETA treatment. …”
Publicado 2014
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1554por Bibi, Haim, Vinokur, Vladimir, Waisman, Dan, Elenberg, Yigal, Landesberg, Amir, Faingersh, Anna, Yadid, Moran, Brod, Vera, Pesin, Jimy, Berenshtein, Eduard, Eliashar, Ron, Chevion, Mordechai“…OBJECTIVE: To examine the anti-inflammatory properties of a newly developed specific iron–chelating complex, Zn/Ga−DFO, in a mouse model of asthma. …”
Publicado 2014
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1555por Liu, Zhe, Romero-Canelón, Isolda, Habtemariam, Abraha, Clarkson, Guy J., Sadler, Peter J.“…[Image: see text] We report the synthesis and characterization of eight half-sandwich cyclopentadienyl Ir(III) pyridine complexes of the type [(η(5)-Cp(xph))Ir(phpy)Z]PF(6), in which Cp(xph) = C(5)Me(4)C(6)H(5) (tetramethyl(phenyl)cyclopentadienyl), phpy = 2-phenylpyridine as C(∧)N-chelating ligand, and Z = pyridine (py) or a pyridine derivative. …”
Publicado 2014
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1556por Löbel, Ulrike, Schweser, Ferdinand, Nickel, Miriam, Deistung, Andreas, Grosse, Regine, Hagel, Christian, Fiehler, Jens, Schulz, Angela, Hartig, Monika, Reichenbach, Jürgen R, Kohlschütter, Alfried, Sedlacik, Jan“…A 13-year-old girl with mitochondrial membrane protein-associated neurodegeneration treated with an iron-chelating agent was monitored by R2 relaxometry, R2* relaxometry, and quantitative susceptibility mapping to estimate the brain iron content. …”
Publicado 2014
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1557por Aguirre, Pabla, Mena, Natalia P., Carrasco, Carlos M., Muñoz, Yorka, Pérez-Henríquez, Patricio, Morales, Rodrigo A., Cassels, Bruce K., Méndez-Gálvez, Carolina, García-Beltrán, Olimpo, González-Billault, Christian, Núñez, Marco T.“…Considering that iron accumulation and oxidative damage are conditions commonly found in PD, we tested the possible neuritogenic effects of iron chelators and antioxidant agents. We used three commercial chelators: DFO, deferiprone and 2.2’-dypyridyl, and three 8-hydroxyquinoline-based iron chelators: M30, 7MH and 7DH, and we evaluated their effects in vitro using a mesencephalic cell culture treated with the Parkinsonian toxin MPP+ and in vivo using the MPTP mouse model. …”
Publicado 2015
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1558por Alnoman, Rua B., Rihn, Sandra, O'Connor, Daniel C., Black, Fiona A., Costello, Bernard, Waddell, Paul G., Clegg, William, Peacock, Robert D., Herrebout, Wouter, Knight, Julian G., Hall, Michael J.“…Helically chiral N,N,O,O‐boron chelated dipyrromethenes showed solution‐phase circularly polarized luminescence (CPL) in the red region of the visible spectrum (λ (em)(max) from 621 to 663 nm). …”
Publicado 2015
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1559por Vossoughinia, Hassan, Pourakbar, Ali, Esfandiari, Samaneh, Sharifianrazavi, Masoud“…Recheck of the BLL showed the level as 53/7 μg/dL. So oral chelator with succimer was started. Despite consumption of oral chelator, there was no response and the pain continued. …”
Publicado 2016
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1560por Sarkar, Aloke, Balakrishnan, Kumudha, Chen, Jefferson, Patel, Viralkumar, Neelapu, Sattva S., McMurray, John S., Gandhi, Varsha“…This study underscores the first genetic evidence that B-PAC-1 driven apoptosis is mediated via Zn chelation.…”
Publicado 2015
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