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1561“…In this study, we analyzed the effect of heavy metals on the fura-2 fluorescence ratio in human SH-SY5Y neuroblastoma cells by using TPEN, a specific cell-permeable heavy metal chelator. Manganese chloride (30–300 µM) did not cause significant changes in the fura-2 fluorescence ratio. …”
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1562por Wongjaikam, Suwakon, Kumfu, Sirinart, Khamseekaew, Juthamas, Sripetchwandee, Jirapas, Srichairatanakool, Somdet, Fucharoen, Suthat, Chattipakorn, Siriporn C., Chattipakorn, Nipon“…BACKGROUND: Iron chelators are used to treat iron overload cardiomyopathy patients. …”
Publicado 2016
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1563por Wang, Xuejuan, Aldrich, Melissa B, Yang, Zhi, Zhou, Nina, Xie, Qing, Liu, Chen, Sevick-Muraca, EvaEnlace del recurso
Publicado 2016
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1564por Polvi, Elizabeth J., Averette, Anna F., Lee, Soo Chan, Kim, Taeyup, Bahn, Yong-Sun, Veri, Amanda O., Robbins, Nicole, Heitman, Joseph, Cowen, Leah E.“…We identified 19 compounds that enhance activity of the echinocandin caspofungin against an echinocandin-resistant clinical isolate, with the broad-spectrum chelator DTPA demonstrating the greatest synergistic activity. …”
Publicado 2016
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1565“…Patients with higher liver iron stores are likely to have a worse cardiac outcome following noncompliance with chelation. Cardiovascular magnetic resonance identifies myocardial siderosis allowing optimization of iron chelation regimes. …”
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1566por Edmonds, Scott, Volpe, Alessia, Shmeeda, Hilary, Parente-Pereira, Ana C., Radia, Riya, Baguña-Torres, Julia, Szanda, Istvan, Severin, Gregory W., Livieratos, Lefteris, Blower, Philip J., Maher, John, Fruhwirth, Gilbert O., Gabizon, Alberto, T. M. de Rosales, Rafael“…The versatility, efficiency, simplicity, and GMP compatibility of this method may enable submicrodosing imaging studies of liposomal nanomedicines containing chelating drugs in humans and may have clinical impact by facilitating the introduction of image-guided therapeutic strategies in current and future nanomedicine clinical studies.…”
Publicado 2016
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1567por Yang, Chunguang, Ma, Xueyou, Wang, Zhihua, Zeng, Xing, Hu, Zhiquan, Ye, Zhangqun, Shen, Guanxin“…Moreover, chemical and biological experiments have evidenced that curcumin is a biologically active iron chelator and induces cytotoxicity through iron chelation. …”
Publicado 2017
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1568por Liang, Yu, Wan, Neng, Cheng, Zao, Mo, Yufeng, Liu, Baolin, Liu, Hui, Raboanatahiry, Nadia, Yin, Yongtai, Li, Maoteng“…Vicinal oxygen chelate proteins (VOC) are members of the metalloenzyme superfamily, which plays roles in many biological reactions. …”
Publicado 2017
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1569“…BACKGROUND: Tannins are often cited for antinutritional effects, including chelation of non-heme iron. Despite this, studies exploring non-heme iron bioavailability inhibition with long-term consumption have reported mixed results. …”
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1570por Fonderico, Mattia, Laudisi, Michele, Andreasi, Nico Golfrè, Bigoni, Stefania, Lamperti, Costanza, Panteghini, Celeste, Garavaglia, Barbara, Carecchio, Miryam, Emanuele, Elia Antonio, Forni, Gian L., Granieri, Enrico“…In reporting relevant clinical data, we want to emphasize the fact that the patient received a chelation therapy with deferiprone (treatment already used in other forms of NBIA with encouraging results), which, however, had to be interrupted because the parkinsonian symptoms worsened. …”
Publicado 2017
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1571Molecular dynamics simulations in drug delivery research: Calcium chelation of G3.5 PAMAM dendrimers“…Using molecular dynamics simulations, we show that the G3.5 PAMAM dendrimers are able to chelate Ca(2+) at similar proportions to EDTA, providing support to the hypothesis that oral formulations of PAMAM dendrimers could use this high chelating efficiency as a potential mechanism for permeating the tight junctions of the intestines if other formulation barriers could be overcome.…”
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1572por Kowalska, Dorota, Szalkowski, Marcin, Ashraf, Khuram, Grzelak, Justyna, Lokstein, Heiko, Niedziolka-Jonsson, Joanna, Cogdell, Richard, Mackowski, Sebastian“…A polyhistidine tag (His-tag) present on Chlorobaculum tepidum reaction centers (RCs) was used to immobilize photosynthetic complexes on a silver nanowire (AgNW) modified with nickel-chelating nitrilo-triacetic acid (Ni-NTA). The optical properties of conjugated nanostructures were studied using wide-field and confocal fluorescence microscopy. …”
Publicado 2017
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1573por Cooray, Shamil D., Heerasing, Neel M., Selkrig, Laura A., Subramaniam, V. Nathan, Hamblin, P. Shane, McDonald, Cameron J., McLean, Catriona A., McNamara, Elissa, Leet, Angeline S., Roberts, Stuart K.“…His condition was stabilized with biventricular assist devices and he was listed for heart transplantation. Iron chelation therapy was commenced and resulted in rapid removal of iron burden. …”
Publicado 2018
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1574por De Rubeis, Silvia, Siper, Paige M., Durkin, Allison, Weissman, Jordana, Muratet, François, Halpern, Danielle, Trelles, Maria del Pilar, Frank, Yitzchak, Lozano, Reymundo, Wang, A. Ting, Holder, J. Lloyd, Betancur, Catalina, Buxbaum, Joseph D., Kolevzon, Alexander“…BACKGROUND: Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder characterized by psychiatric and neurological features. …”
Publicado 2018
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1575por Young, Sherri C.“…In this review, the biological activities, structures, and physicochemical properties for several amyloid-targeting peptoids will be described. In addition, metal-chelating peptoids with the potential to treat AD will be discussed since there are connections between the dysregulation of certain metals and the amyloid pathway.…”
Publicado 2018
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1576por Shinoda, Shuhei, Kaino, Seiji, Amano, Shogo, Harima, Hirofumi, Matsumoto, Toshihiko, Fujisawa, Koichi, Takami, Taro, Yamamoto, Naoki, Yamasaki, Takahiro, Sakaida, Isao“…We have reported that deferasirox (DFX), an oral iron chelator, showed antiproliferative activity against pancreatic cancer cells. …”
Publicado 2018
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1577por Guo, Melinda, Her, Sohyoung, Keunen, Rachel, Zhang, Shengmiao, Allen, Christine, Winnik, Mitchell A.“…For the first time, PEGylated metal-chelating polymers containing diethylenetriaminepentaacetic acid (DTPA) (i.e., mPEG-PGlu(DPTA)(18)-HyNic and PEG-PGlu(DPTA)(25)-HyNic) are conjugated to CNCs to enable the chelation of radionuclides for diagnostic and therapeutic applications. …”
Publicado 2016
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1578por Zhao, Qian, Piao, Jiafang, Peng, Weipan, wang, Jun, Gao, Weichen, Wu, Xiaoli, Wang, Hanjie, Gong, Xiaoqun, Chang, Jin, Zhang, Bingbo“…Here, an enzyme‐free assay is reported that relies on the strong chelating capability of ethylenediamine tetraacetic acid disodium salt (EDTA•2Na, the chelator) for Au(3+) ions, in which the cheap EDTA•2Na labeled by targeting moieties can selectively regulate the growth of plasmonic gold nanoparticles (AuNPs) at the target site subjecting to the concentration of analyte in samples. …”
Publicado 2018
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1579
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1580por Karczmarczyk, Urszula, Wojdowska, Wioletta, Mikołajczak, Renata, Maurin, Michał, Laszuk, Ewa, Garnuszek, PiotrEnlace del recurso
Publicado 2018
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