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41por Cui, Mengchu, Zhou, Tao, Feng, Shiyu, Liu, Xinyun, Wang, Fuyu, Zhang, Yanyang, Yu, Xinguang“…A growing body of evidence suggests that altered brain structure plays a crucial role in the pathogenesis of neuropsychological abnormalities induced by hypercortisolism in patients with Cushing’s disease. While most studies mainly focus on gray matter, white matter structure has been largely overlooked. …”
Publicado 2021
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42por Machado, Márcio Carlos, Fragoso, Maria Candida Barisson Vilares, Moreira, Ayrton Custódio, Boguszewski, César Luiz, Vieira, Leonardo, Naves, Luciana A., Vilar, Lucio, de Araújo, Luiz Antônio, Musolino, Nina Rosa Castro, Miranda, Paulo Augusto C., Czepielewski, Mauro A., Gadelha, Monica R., Bronstein, Marcello Delano, Ribeiro-Oliveira, Antônio“…Transsphenoidal pituitary surgery is the main treatment option for the majority of cases, even in macroadenomas with low probability of remission. …”
Publicado 2018
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43por Machado, Márcio Carlos, Fragoso, Maria Candida Barisson Vilares, Moreira, Ayrton Custódio, Boguszewski, César Luiz, Vieira, Leonardo, Naves, Luciana A., Vilar, Lucio, de Araújo, Luiz Antônio, Czepielewski, Mauro A., Gadelha, Monica R., Musolino, Nina Rosa Castro, Miranda, Paulo Augusto C, Bronstein, Marcello Delano, Ribeiro-Oliveira, Antônio“…Magnetic resonance imaging (MRI) of the pituitary, the corticotropin-releasing hormone (CRH) test and the high-dose dexamethasone suppression test are the main tests for the differential diagnosis of ACTH-dependent Cushing’s syndrome. …”
Publicado 2016
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44“…In addition to cortisol-producing adenomas, bilateral micronodular adrenocortical disease and primary bilateral macronodular adrenal hyperplasia (PBMAH) have also expanded the spectrum of benign neoplasms causing adrenal Cushing disease. The recent discovery of inactivating ARMC5 germline mutations in PBMAH has challenged the old belief that this disorder is mainly a sporadic disease. …”
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45por Larose, Stéphanie, Bondaz, Louis, Mermejo, Livia M., Latour, Mathieu, Prosmanne, Odile, Bourdeau, Isabelle, Lacroix, André“…The left adrenal was predominantly composed of myelolipoma and strands of BMAH, while the right was mainly composed of BMAH with some foci of myelolipoma on pathology. …”
Publicado 2019
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46por Hernández-Ramírez, Laura C, Gam, Ryhem, Valdés, Nuria, Lodish, Maya B, Pankratz, Nathan, Balsalobre, Aurelio, Gauthier, Yves, Faucz, Fabio R, Trivellin, Giampaolo, Chittiboina, Prashant, Lane, John, Kay, Denise M, Dimopoulos, Aggeliki, Gaillard, Stephan, Neou, Mario, Bertherat, Jérôme, Assié, Guillaume, Villa, Chiara, Mills, James L, Drouin, Jacques, Stratakis, Constantine A“…Its function might link two of the main molecular mechanisms altered in corticotropinomas: the cyclin-dependent kinase/cyclin group of cell cycle regulators and the epidermal growth factor receptor signaling pathway. …”
Publicado 2017
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47“…Main outcome measures Incidence of cardiovascular events within a year after diagnosis of iatrogenic Cushing’s syndrome or after a randomly selected date, and association between iatrogenic Cushing’s syndrome and risk of cardiovascular events. …”
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48“…In a patient with Cushing's syndrome (CS), the anaesthesiologist needs to deal with volume overload, hyperglycaemia, hypokalaemia, difficult airway and ventilation. …”
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49por Ishay, Avraham, Touma, Elia, Vornicova, Olga, Dodiuk-Gad, Roni, Goldman, Tal, Bisharat, Naiel“…BACKGROUND: Ectopic Cushing syndrome (ECS) is a rare condition commonly associated with neuroendocrine tumors (NET), mainly bronchial carcinoids. …”
Publicado 2022
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50“…Cushing's syndrome is a rare entity, and a high index of suspicion is needed for screening in a primary care setting. …”
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51“…Small cell carcinoma and carcinoid of the lung comprises half of its cases. The main purpose of this study is to present a case of ectopic Cushing syndrome caused by a hidden lung carcinoid and how to manage it. …”
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52por Guarnotta, Valentina, Emanuele, Fabrizio, Salzillo, Riccardo, Bonsangue, Maria, Amato, Carlotta, Mineo, Mariagrazia Irene, Giordano, Carla“…Currently, the landscape of approved agents for treatment of diabetes is dynamic and is mainly patient-centred and not glycaemia-centred. …”
Publicado 2023
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53por Liu, Shuai, Wang, Yinyan, Xu, Kaibin, Ping, Fan, Li, Fang, Wang, Renzhi, Cheng, Xin“…Cognitive impairment and psychiatric symptoms are common in patients with Cushing's disease (CD) owing to elevated levels of glucocorticoids. …”
Publicado 2017
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54por Eulate-Beramendi, Sayoa, Casajús, Ainhoa, Ollero, Lola, Niemann, Lynnette K., Fernández-Miranda, Juan Carlos, Bruneau, Michaël, Berhouma, Moncef, Cavallo, Luigi Maria, Cornelius, Jan Frederick, Daniel, Roy T., Froelich, Sebastien, Jouanneau, Emmanuel, Kasper, Ekkehard, Mazzatenta, Diego, Meling, Torstein R., Messerer, Mahmoud, Schroeder, Henry W.S., Tatagiba, Marcos, Visocchi, Massimiliano, Voormolen, Eduard H., Zazpe, Idoya“…INTRODUCTION: Cushing's disease is a state of chronic and excessive cortisol levels caused by a pituitary adenoma RESEARCH QUESTION: CD is a complex entity and often entails difficulties in its diagnosis and management. …”
Publicado 2022
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55Increased Mortality Persists after Treatment of Cushing’s Disease: A Matched Nationwide Cohort Studypor Bengtsson, Daniel, Ragnarsson, Oskar, Berinder, Katarina, Dahlqvist, Per, Edén Engström, Britt, Ekman, Bertil, Höybye, Charlotte, Järås, Jacob, Valdemarsson, Stig, Burman, Pia, Wahlberg, Jeanette“…Four controls per patient (n = 1484) matched at the diagnosis date by age, sex, and residential area were included. MAIN OUTCOME MEASURES: Mortality and causes of death. …”
Publicado 2022
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56por Dormoy, Alexandre, Haissaguerre, Magalie, Vitellius, Géraldine, Do Cao, Christine, Geslot, Aurore, Drui, Delphine, Lasolle, Hélène, Vieira-Pinto, Oceana, Salenave, Sylvie, François, Maud, Puerto, Marie, Boullay, Hélène Du, Mayer, Anne, Rod, Anne, Laurent, Claire, Chanson, Philippe, Reznik, Yves, Castinetti, Frédéric, Chabre, Olivier, Baudin, Eric, Raverot, Gérald, Tabarin, Antoine, Young, Jacques“…CONTEXT: Prospective studies have demonstrated the efficacy of osilodrostat in Cushing disease. No study has evaluated osilodrostat in a series of patients with paraneoplastic Cushing syndrome/ectopic adrenocorticotropin syndrome (PNCS/EAS). …”
Publicado 2022
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57por Miao, Sisi, Lu, Lin, Li, Ling, Wang, Yining, Lu, Zhaolin, Zhu, Huijuan, Wang, Linjie, Duan, Lian, Xing, Xiaoping, Yao, Yong, Feng, Ming, Wang, Renzhi“…Background: Endogenous Cushing's syndrome (CS), also called hypercortisolism, leads to a significant increase in mortality due to excessive cortisol production, which is mainly due to cardiovascular disease. …”
Publicado 2021
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58“…In the context of ACTH‐dependent Cushing's syndrome, ectopic ACTH secretion from a neuroendocrine tumour is not uncommon, and needs to be carefully differentiated from pituitary‐dependent Cushing's syndrome, Cushing's disease, in order to optimise therapy. …”
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59“…Shah: None. Introduction: Cushing’s disease (CD); the most common cause of endogenous Cushing’s syndrome (CS) is mainly caused by an adrenocorticotropin (ACTH)-secreting pituitary adenomas. …”
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60por Petramala, Luigi, Lorenzo, D'Elia, Iannucci, Gino, Concistré, Antonio, Zinnamosca, Laura, Marinelli, Cristiano, De Vincentis, Giuseppe, Ciardi, Antonio, De Toma, Giorgio, Letizia, Claudio“…BACKGROUND: Cushing syndrome (CS) has been described as a killing disease due its cardiovascular complications. …”
Publicado 2015
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