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61por Roerink, Sean H. P. P., Wagenmakers, M. A. E. M., Smit, J. W. A., van Rossum, E. F. C., Netea-Maier, R. T., Plantinga, T. S., Hermus, A. R. M. M.“…Associations between GR polymorphisms and multiple vascular, body composition and metabolic parameters were investigated. MAIN OUTCOME MEASURES: Allelic frequencies of the polymorphisms and their associations with several cardiometabolic risk factors. …”
Publicado 2016
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62“…CONCLUSION: While well-described in older children and adults, in neonates the Cushing reflex has mainly been described in animal experiments and infants who have developed hydrocephalus. …”
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63“…Background: Autonomous glucocorticoid excess in patients with Cushing disease (CD) may lead to negative feedback suppression, resulting in Crooke's hyaline change (CC) of the non-tumorous corticotrophs in the pituitary. …”
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64por Pupier, Emilie, Santos, Alicia, Etchamendy, Nicole, Lavielle, Aurélie, Ferriere, Amandine, Marighetto, Aline, Resmini, Eugenia, Cota, Daniela, Webb, Susan M., Tabarin, Antoine“…CONTEXT: Impaired cognition and altered quality of life (QoL) may persist despite long-term remission of Cushing’s disease (CD). Persistent comorbidities and treatment modalities may account for cognitive impairments. …”
Publicado 2022
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65por Mallari, Regin Jay, Thakur, Jai Deep, Barkhoudarian, Garni, Eisenberg, Amy, Rodriguez, Amanda, Rettinger, Sarah, Cohan, Pejman, Nieman, Lynnette, Kelly, Daniel F“…CONTEXT: Confirming a diagnosis of Cushing disease (CD) remains challenging, yet is critically important before recommending transsphenoidal surgery for adenoma resection. …”
Publicado 2021
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66por Firme, Ricardo“…Salivary cortisol increased in comparison to baseline in patients with Cushing’s disease (range: 66 to 309%) mainly at 60 minutes, declining thereafter. …”
Publicado 2019
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67“…BACKGROUND: Cushing’s syndrome (CS) is a rare clinical condition caused by excessive cortisol secretion from adrenal glands. …”
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68por Yasuda, Atsushi, Seki, Toshiro, Kametani, Yoshie, Koizumi, Masahiro, Kitajima, Natsumi, Oki, Masayuki, Seki, Masami, Kakuta, Takatoshi, Fukagawa, Masafumi“…ACTH-independent Cushing's syndrome (CS) is mainly caused by cortisol-secreting adrenocortical tumours. …”
Publicado 2019
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69por González Fernández, Laura, Maricel Rivas Montenegro, Alejandra, Brox Torrecilla, Noemí, Miguélez González, María, Atencia Goñi, Jose, Fernández Fernández, Elisa, González Albarrán, Olga, Carlos Pércovich Hualpa, Juan, Sambo Salas, Marcel, García Centeno, Rogelio“…Ectopic Cushing’s syndrome (ECS) is a rare disease associated with significant comorbidity. …”
Publicado 2023
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70por Kannankeril, Joshua, Carroll, Ty, Findling, James W, Javorsky, Bradley, Gunsolus, Ian L, Phillips, Jonathan, Raff, Hershel“…CONTEXT: Late-night salivary cortisol (LNSC) measured by enzyme immunoassay (EIA-F) is a first-line screening test for Cushing syndrome (CS) with a reported sensitivity and specificity of >90%. …”
Publicado 2020
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71por Bengtsson, Daniel, Ragnarsson, Oskar, Berinder, Katarina, Dahlqvist, Per, Edén Engström, Britt, Ekman, Bertil, Höybye, Charlotte, Burman, Pia, Wahlberg, Jeanette“…CONTEXT: Psychiatric symptoms are common in Cushing’s disease (CD) and seem only partly reversible following treatment. …”
Publicado 2021
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72por Mariani, Beatriz Marinho de Paula, Nishi, Mirian Yumie, Wanichi, Ingrid Quevedo, Brondani, Vania Balderrama, Lacombe, Amanda Meneses Ferreira, Charchar, Helaine, Pereira, Maria Adelaide Albergaria, Srougi, Victor, Tanno, Fabio Yoshiaki, Ceccato, Filippo, Regazzo, Daniela, Barbot, Mattia, Occhi, Gianluca, Albiger, Nora Maria Elvira, Vieira-Corrêa, Marcelo, Kater, Claudio Elias, Scaroni, Carla, Chambô, José Luis, Zerbini, Maria Claudia Nogueira, Mendonca, Berenice B., Almeida, Madson Q., Fragoso, Maria Candida Barisson Villares“…Objective: Germline ARMC5 mutations are considered to be the main genetic cause of primary macronodular adrenal hyperplasia (PMAH). …”
Publicado 2020
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73por Minuzzi, Ricardo Kunde, Landenberger, Giullia Menuci, Pereira Lima, Julia Fernanda Semmelmann, Oliveira, Miriam da Costa, Leães Rech, Carolina Garcia Soares“…In these cases, when considering ACTH-independent hypercortisolism, the main etiology reported is adrenal adenoma. We will describe the case of an acromegalic patient with ACTH-independent cushing syndrome due to adrenal cortical carcinoma. …”
Publicado 2020
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74por Mascarenhas-Nakano, Bruna Maria Grosso, Santos-Neto, Pedro Felisberto, Corrêa Portari, Luiz Henrique, Correa-Silva, Silvia Regina, Abucham, JulioEnlace del recurso
Publicado 2023
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75por Kim, Kyungwon“…Serum ACTH level determines the successful lateralization of ACTH secreting pituitary tumor in Cushing disease. Presentation: Thursday, June 15, 2023…”
Publicado 2023
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76por Fleseriu, Maria, Pivonello, Rosario, Young, Jacques, Hamrahian, Amir H., Molitch, Mark E., Shimizu, Chikara, Tanaka, Tomoaki, Shimatsu, Akira, White, Tracy, Hilliard, Annie, Tian, Chuan, Sauter, Nicholas, Biller, Beverly MK, Bertagna, Xavier“…PURPOSE: In a 10-week proof-of-concept study (LINC 1), the potent oral 11β-hydroxylase inhibitor osilodrostat (LCI699) normalized urinary free cortisol (UFC) in 11/12 patients with Cushing’s disease. The current 22-week study (LINC 2; NCT01331239) further evaluated osilodrostat in patients with Cushing’s disease. …”
Publicado 2015
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77por Sakaguchi, Chihiro, Ashida, Kenji, Kohashi, Kenichi, Ohe, Kenji, Fujii, Yoichi, Yano, Seiichi, Matsuda, Yayoi, Sakamoto, Shohei, Sakamoto, Ryuichi, Oda, Yoshinao, Nomura, Masatoshi, Ogawa, Yoshihiro“…BACKGROUND: Increased urinary free cortisol in response to the oral administration of dexamethasone is a paradoxical reaction mainly reported in patients with primary pigmented nodular adrenocortical disease. …”
Publicado 2019
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78por Detomas, Mario, Altieri, Barbara, Deutschbein, Timo, Fassnacht, Martin, Dischinger, Ulrich“…BACKGROUND: Although surgery is considered the first-line treatment for patients with endogenous Cushing’s syndrome (CS), medical therapy is often required to control severe hypercortisolism. …”
Publicado 2022
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79por Settas, Nikolaos, Kassi, Eva, Angelousi, Anna, Faucz, Fabio Rueda, Stratakis, Constantine A“…Clinical cases: Herein, we present two unrelated patients with ACTH-independent CS that harbor USP8 gene variants. USP8 is mainly known for being mutated in Cushing disease but as a deubiquitinase it may be involved into the Wnt/β-Catenin signaling pathway. …”
Publicado 2020
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80“…Cushing´s syndrome (CS) secondary to bilateral adrenal cortical disease may be caused by bilateral macronodular adrenal cortical disease (BMACD) or by bilateral micronodular adrenal cortical disease (miBACD). …”
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