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101por Bertherat, Jérôme“…Heterozygous inactivating mutations of PRKAR1A were reported initially in 45 to 65 % of CNC index cases, and may be present in about 80 % of the CNC families presenting mainly with Cushing's syndrome. PRKAR1A is a key component of the cAMP signaling pathway that has been implicated in endocrine tumorigenesis and could, at least partly, function as a tumor suppressor gene. …”
Publicado 2006
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102por Zieliński, Grzegorz, Sajjad, Emir Ahmed, Maksymowicz, Maria, Pękul, Monika, Koziarski, Andrzej“…RESULTS: There were 21 cases of synchronous and one case of asynchronous double pituitary adenoma. The main clinical finding was acromegaly (12/22) followed by Cushing’s disease (3/22). …”
Publicado 2019
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103por Esparza-Salazar, Felipe J., Hernández-González, Jhosue A., Lezama-Toledo, Alma R., Incontri-Abraham, Diego, Corral, Armando, Armenta-Moreno, Javier I., Vargas-Abonce, Valerie P., Cuevas-Ramos, Daniel, Gómez-Pérez, Francisco J., Gómez-Sámano, Miguel A.“…CONCLUSION: NS develops as a complication of TBA, which is used as a treatment of Cushing disease. The main treatment is surgery and radiotherapy.…”
Publicado 2020
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104por Mebrahtu, Teumzghi F, Morgan, Ann W, Keeley, Adam, Baxter, Paul D, Stewart, Paul M, Pujades-Rodriguez, Mar“…CONTEXT: Adrenal insufficiency and Cushing syndrome are known adverse events of glucocorticoids. …”
Publicado 2019
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105por Zhu, Dimin, Wang, Zongming, Tian, Tian, Wu, Xinyi, He, Dongsheng, Zhu, Yonghong, Liu, Dawei, Wang, Haijun“…Cases reported in the literature were mainly female (72.8%), and the clinical presentation was also dominated by Cushing’s syndrome (65.1%) and hormonal dysfunction. …”
Publicado 2022
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106por Vieira-Corrêa, Marcelo, Moroto, Débora, Carpentieri, Giovanna, Veras, Igor, Kater, Claudio E.“…The majority of endogenous CS is caused by excessive ACTH secretion, mainly due to a pituitary tumor – the so-called Cushing’s disease (CD) – followed by ectopic ACTH syndrome (EAS), an extra-pituitary tumor that produces ACTH; adrenal causes of CS are even rarer. …”
Publicado 2019
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107“…A vertical closure with a Cushing type continuous suture may be more successful than interrupted sutures in preventing a PCF.…”
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108por Lee, Seung-Eun, Kim, Jae Hyeon, Lee, You-Bin, Seok, Hyeri, Shin, In Seub, Eun, Yeong Hee, Kim, Jung-Han, Oh, Young Lyun“…A 31-year-old woman was referred to our hospital with symptoms of hypertension and bilateral adrenocortical masses with no feature of Cushing syndrome. The serum aldosterone/renin ratio was elevated and the saline loading test showed no suppression of the plasma aldosterone level, consistent with a diagnosis of primary hyperaldosteronism. …”
Publicado 2015
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109“…Neuroendocrine neoplasms (NENs) originate from neuroendocrine cells, and mainly occur in the gastrointestinal tract and lungs, rarely occurring in the orbit. …”
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110por Liu, Yang, Feng, Ming, Yao, Yong, Deng, Kan, Bao, Xinjie, Liu, Xiaohai, Wang, Renzhi“…Radiation and pharmaceutical treatment may be alternative for recurrent Cushing disease.…”
Publicado 2017
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111por Ziglioli, Francesco, Cataldo, Simona, Cavalieri, Domenico Maria, Campobasso, Davide, Maestroni, Umberto“…The treatment of post-surgical AI is based mainly on glucocorticoid supplementation therapy. …”
Publicado 2022
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112“…The symptoms and signs were milder than PCCs. AMHs were mainly found due to screening. Outcomes seemed favorable, but new PCCs developed in many during follow-up.…”
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113por Favero, Vittoria, Cremaschi, Arianna, Falchetti, Alberto, Gaudio, Agostino, Gennari, Luigi, Scillitani, Alfredo, Vescini, Fabio, Morelli, Valentina, Aresta, Carmen, Chiodini, Iacopo“…Mild hypercortisolism (mHC) is defined as an excessive cortisol secretion, without the classical manifestations of clinically overt Cushing’s syndrome. This condition increases the risk of bone fragility, neuropsychological alterations, hypertension, diabetes, cardiovascular events and mortality. …”
Publicado 2021
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114“…Nearly 60% of patients with Cushing's syndrome have muscle weakness. Glucocorticoid-induced muscle atrophy affects mainly fast-twitch glycolytic muscle fibers (type IIb fibers). …”
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115“…Seven out of nine patients who were treated for cryptococcus infection before receiving CS survived, while three patients treated for cryptococcus infection after CS treatment developed signs of IRIS and eventually died. CONCLUSION: Cushing's syndrome, complicated with cryptococcal infection, has a high mortality rate, mainly when IRIS emerges. …”
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116“…In this concise review, we present an overview of research on dream recall/affect and of the hypothalamic–pituitary–adrenal (HPA) axis, discussing caveats regarding the action of hormones of the HPA axis (mainly cortisol and its free form, cortisol-binding globulin and glucocorticoid receptors). …”
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117por Chen, Ye-ye, Li, Shan-qing, Liu, Hong-sheng, Qin, Ying-zhi, Li, Li, Huang, Cheng, Bi, Ya-lan, Meng, Yun-xiao, He, Jia, Zhou, Xiao-yun, Ma, Dong-jie“…The current literature on this topic consists mainly of case reports, and therapeutic guidelines are lacking. …”
Publicado 2016
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118“…The patients with A/CPTs are mainly combined with subclinical Cushing syndrome, and prone to need glucocorticoid replacement therapy. …”
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119Somatostatin Receptor Subtype Expression in Patients with Acromegaly and Complicated Clinical Coursepor Pichler, Robert, Kalev, Ognian, Tomancok, Berndt, Sonnberger, Michael, Ehrlich, Daniela, Hodolic, Marina“…An efficient drug for Cushing’s disease tailored to suboptimal-responding patients with acromegaly then became available. …”
Publicado 2021
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120por Joergens, Viki“…Some 20 years after their discovery, how Brown Dwarfs form is still one of the main open questions in the theory of star formation. …”
Publicado 2014
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