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121por Numakura, Kazuyuki, Nara, Taketoshi, Kanda, Sohei, Saito, Mitsuru, Narita, Shintaro, Inoue, Takamitsu, Habuchi, Tomonori“…Autonomous GC secretion is the main feature of primary adrenal hypercortisolism (PAHC). …”
Publicado 2019
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122“…Among the hyperfunctional adrenal masses, Cushing's syndrome, pheochromocytoma, and primary aldosteronism are receiving particularly great attention due to their high morbidity and mortality mainly by increasing cardiovascular risk. …”
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123“…Adrenocorticotropic hormone (ACTH)-secreting pituitary tumors mainly express somatostatin receptor 5 (SSTR5) since SSTR2 is downregulated by the elevated levels of glucocorticoids that characterize patients with Cushing’s disease (CD). …”
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124por Popoviciu, Mihaela Simona, Paduraru, Lorena, Nutas, Raluca Marinela, Ujoc, Alexandra Maria, Yahya, Galal, Metwally, Kamel, Cavalu, Simona“…The main endocrinopathies (acromegaly, Cushing’s syndrome, Basedow–Graves’ disease, pheochromocytoma, somatostatinoma and glucagonoma) and their characteristics are described along with the impact of hormone changes on blood sugar, body mass index and other parameters associated with diabetes. …”
Publicado 2023
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125por Agaimy, Abbas, Kasajima, Atsuko, Stoehr, Robert, Haller, Florian, Schubart, Christoph, Tögel, Lars, Pfarr, Nicole, von Werder, Alexander, Pavel, Marianne E., Sessa, Fausto, Uccella, Silvia, La Rosa, Stefano, Klöppel, Günter“…Ectopic Cushing syndrome is a rare clinical disorder resulting from excessive adrenocorticotrophic hormone (ACTH) produced by non-pituitary neoplasms, mainly neuroendocrine neoplasms (NENs) of the lung, pancreas, and gastrointestinal tract, and other less common sites. …”
Publicado 2023
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126“…Hormonal work up was negative for Cushing syndrome and hyperaldosteronism. Plasma metanephrine was 0.50 with elevated plasma normetanephrine of 3.85. …”
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127por Regazzo, Daniela, Mondin, Alessandro, Scaroni, Carla, Occhi, Gianluca, Barbot, Mattia“…The resulting clinical picture is called Cushing’s disease (CD), a severe condition burdened with high morbidity and mortality. …”
Publicado 2022
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128por Meunier, Solène, Groessl, Michael, Reusch, Claudia, Boretti, Felicitas, Sieber-Ruckstuhl, Nadja“…BACKGROUND: Salivary cortisol collected at home is a useful test to diagnose and monitor Cushing’s syndrome in humans. The main problem in dogs is to retrieve a sufficient amount of saliva. …”
Publicado 2021
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129“…We report the case of a 36-year-old male with a history of CAH on steroids since childhood, self-discontinued shortly after diagnosis, presenting mainly with abdominal distension and pain besides infertility. …”
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130por Paragliola, Rosa Maria, Papi, Giampaolo, Pontecorvi, Alfredo, Corsello, Salvatore Maria“…This effect is mediated by the negative feedback loop on the hypothalamus-pituitary-adrenal (HPA) axis, which mainly involves corticotropin-release hormone (CRH), which represents the most important driver of adrenocorticotropic hormone (ACTH) release. …”
Publicado 2017
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131“…Autoantibodies against gonadotropic cells were mainly found in patients affected by cryptorchidism and hypogonadotropic hypogonadism while those against prolactin cells were found in different kinds of patients, the majority without pituitary abnormalities. …”
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132“…In this review, among endocrine causes of HTN, we will mainly discuss explorations for PA and PPGL.…”
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133por Neumann, Hartmut P. H., Tsoy, Uliana, Bancos, Irina, Amodru, Vincent, Walz, Martin K., Tirosh, Amit, Kaur, Ravinder Jeet, McKenzie, Travis, Qi, Xiaoping, Bandgar, Tushar, Petrov, Roman, Yukina, Marina Y., Roslyakova, Anna, van der Horst-Schrivers, Anouk N. A., Berends, Annika M. A., Hoff, Ana O., Castroneves, Luciana Audi, Ferrara, Alfonso Massimiliano, Rizzati, Silvia, Mian, Caterina, Dvorakova, Sarka, Hasse-Lazar, Kornelia, Kvachenyuk, Andrey, Peczkowska, Mariola, Loli, Paola, Erenler, Feyza, Krauss, Tobias, Almeida, Madson Q., Liu, Longfei, Zhu, Feizhou, Recasens, Mònica, Wohllk, Nelson, Corssmit, Eleonora P. M., Shafigullina, Zulfiya, Calissendorff, Jan, Grozinsky-Glasberg, Simona, Kunavisarut, Tada, Schalin-Jäntti, Camilla, Castinetti, Frederic, Vlček, Petr, Beltsevich, Dmitry, Egorov, Viacheslav I., Schiavi, Francesca, Links, Thera P., Lechan, Ronald M., Bausch, Birke, Young, William F., Eng, Charis“…EXPOSURES: Total or cortical-sparing adrenalectomy. MAIN OUTCOMES AND MEASURES: Primary adrenal insufficiency, recurrent pheochromocytoma, and mortality. …”
Publicado 2019
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134por Zhong, Jia-Yu, Cui, Rong-Rong, Lin, Xiao, Xu, Feng, Zhu, Ting, Li, Fuxingzi, Wu, Feng, Zhou, En, Yi, Lu, Yuan, Ling-Qing“…Cortisol-producing adenoma (CPA) is the main cause of Adrenal Cushing syndrome. However, its molecular mechanism is not fully understood. …”
Publicado 2019
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135por Beaupere, Carine, Liboz, Alexandrine, Fève, Bruno, Blondeau, Bertrand, Guillemain, Ghislaine“…Next, we describe in detail the molecular mechanisms underlying GC-induced insulin resistance in adipose tissue, liver, muscle, and to a lesser extent in gut, bone, and brain, mainly identified by numerous studies performed in animal models. …”
Publicado 2021
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136“…Cyclic-AMP (cAMP)-dependent protein kinase (PKA) is the main effector of cAMP signaling in all tissues. Inactivating mutations of the PRKAR1A gene, coding for the type 1A regulatory subunit of PKA, are responsible for Carney complex and primary pigmented nodular adrenocortical disease (PPNAD). …”
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137“…Ideal PT levels in comparison with auxological data have not been reported. The main purpose of this study was to analyze ideal PT values as an index of optimal control for CYP21A2 deficiency. …”
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138por Reel, Smarti, Reel, Parminder S., Erlic, Zoran, Amar, Laurence, Pecori, Alessio, Larsen, Casper K., Tetti, Martina, Pamporaki, Christina, Prehn, Cornelia, Adamski, Jerzy, Prejbisz, Aleksander, Ceccato, Filippo, Scaroni, Carla, Kroiss, Matthias, Dennedy, Michael C., Deinum, Jaap, Eisenhofer, Graeme, Langton, Katharina, Mulatero, Paolo, Reincke, Martin, Rossi, Gian Paolo, Lenzini, Livia, Davies, Eleanor, Gimenez-Roqueplo, Anne-Paule, Assié, Guillaume, Blanchard, Anne, Zennaro, Maria-Christina, Beuschlein, Felix, Jefferson, Emily R.“…It occurs due to underlying conditions associated with hormonal excess mainly related to adrenal tumours and sub-categorised: primary aldosteronism (PA), Cushing’s syndrome (CS), pheochromocytoma or functional paraganglioma (PPGL). …”
Publicado 2022
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139por Araújo, Antônio Victor Santos, Lacerda, Amanda Araújo, de Oliveira, Amanda Alves, Filho, Euler Nicolau Sauaia“…BACKGROUND: Harvey Cushing and collaborators created the first society of neurosurgeons in 1920, in the United States of America, the Society of Neurological Surgeons. …”
Publicado 2023
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140por Villagarcía, Hernán Gonzalo, Sabugo, Vanesa, Castro, María Cecilia, Schinella, Guillermo, Castrogiovanni, Daniel, Spinedi, Eduardo, Massa, María Laura, Francini, Flavio“…These features, shared by both metabolic and Cushing's syndrome human phenotypes, support that a chronic glucocorticoid-rich endogenous environment mainly impacts on hepatic glucose cycle, displacing local metabolism to lipogenesis. …”
Publicado 2016
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