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141“…However, medical/pharmacological therapy plays an important role in controlling hormone-producing pituitary adenomas, especially for patients with acromegaly and Cushing disease (CD). In the case of non-functioning pituitary adenomas (NFAs), pharmacological therapy plays a minor role, the main objective of which is to reduce tumor growth, but this role requires further studies. …”
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142por van der Valk, Eline S., van den Akker, Erica L.T., Savas, Mesut, Kleinendorst, Lotte, Visser, Jenny A., Van Haelst, Mieke M., Sharma, Arya M., van Rossum, Elisabeth F.C.“…Adult patients consulting a doctor for weight gain or obesity should first be clinically assessed for underlying diseases, such as monogenetic or syndromic obesity, hypothyroidism, (cyclic) Cushing syndrome, polycystic ovarian syndrome (PCOS), hypogonadism, growth hormone deficiency, and hypothalamic obesity. …”
Publicado 2019
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143“…Adrenocortical Carcinoma might cause related hormonal syndromes such as Cushing syndrome, Conn syndrome, and virilization. …”
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144por Favero, Vittoria, Cremaschi, Arianna, Parazzoli, Chiara, Falchetti, Alberto, Gaudio, Agostino, Gennari, Luigi, Scillitani, Alfredo, Vescini, Fabio, Morelli, Valentina, Aresta, Carmen, Chiodini, Iacopo“…This high variability is mainly due to the different criteria used for defining this condition. …”
Publicado 2022
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145por Marok, Fatima Zahra, Wojtyniak, Jan-Georg, Fuhr, Laura Maria, Selzer, Dominik, Schwab, Matthias, Weiss, Johanna, Haefeli, Walter Emil, Lehr, Thorsten“…The antifungal ketoconazole, which is mainly used for dermal infections and treatment of Cushing’s syndrome, is prone to drug–food interactions (DFIs) and is well known for its strong drug–drug interaction (DDI) potential. …”
Publicado 2023
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146“…Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of adrenocorticotropin hormone (ACTH)-independent Cushing’s syndrome (CS), which mainly occurs in children and young adults. …”
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147por Akram, Muhammad, Waratchareeyakul, Watcharee, Haupenthal, Joerg, Hartmann, Rolf W., Schuster, Daniela“…Cortisol synthase (CYP11B1) is the main enzyme for the endogenous synthesis of cortisol and its inhibition is a potential way for the treatment of diseases associated with increased cortisol levels, such as Cushing's syndrome, metabolic diseases, and delayed wound healing. …”
Publicado 2017
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148por Higashitani, Takuya, Aono, Daisuke, Kometani, Mitsuhiro, Karashima, Shigehiro, Demura, Masashi, Yoneda, Takashi, Takeda, Yoshiyu“…Abdominal magnetic resonance angiography demonstrated marked stenosis of the left main renal artery. The patient was subsequently diagnosed with atherosclerotic RVHT with left renal artery stenosis. …”
Publicado 2020
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149“…Excessive glucocorticoid as often seen in Cushing's syndrome causes water retention. However, whether and how glucocorticoid regulates AQP2 remains unclear. …”
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150por Farhan, Syed A, Shaikh, Ali T, Zia, Maria, Kahara, Bilal R, Muneer, Ramsha, Rehman, Muzna, Mubashir, Ayesha, Sadiq, Hassaan, Siddiqui, Durr-e-Amna, Haseeb, Syed M, Tanveer, Hafsa, Siddiq, Khadijah, Mujtaba, Saib B, Mirza, Samir A, Feroz, Hira, Fatima, Kaneez“…Non-diabetics, patients having gestational diabetes, diabetes insipidus and Cushing’s syndrome and terminally ill patients were excluded. …”
Publicado 2017
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151por Frederiksen, Anja, Rossing, Maria, Hermann, Pernille, Ejersted, Charlotte, Thakker, Rajesh V, Frost, Morten“…PATIENTS: We report a large Danish family with multiple cases of endocrine tumors that segregated with a pathogenic variant in the CDKN1B gene. MAIN OUTCOME/RESULT: The medical history of the proband included primary hyperparathyroidism and Cushing disease. …”
Publicado 2019
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152por Chiou, Hsin-Ying Clair, Jiang, He-Jiun, Yang, Sheau-Fang, Kuo, Kung-Kai, Lin, Pi-Chen, Hsiao, Pi-Jung“…We reported a 32-year-old female, manifested with typical Cushing’s syndrome and hypertension, to be diagnosed with right huge adrenal mixed corticomedullary tumor (8.8 cm). …”
Publicado 2020
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153por Frara, Stefano, Allora, Agnese, Castellino, Laura, di Filippo, Luigi, Loli, Paola, Giustina, Andrea“…Several pituitary diseases, such as hypopituitarism and Cushing disease, or due to frequent comorbidities such as diabetes may be a risk factor for severe COVID-19 in affected patients. …”
Publicado 2021
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154“…According to the KEGG pathway analysis, the most enriched pathways were those involved in transcriptional misregulation in cancer, growth hormone synthesis, secretion and action, endocrine resistance, axon guidance, and Cushing syndrome. Pathway analysis was mainly involved in the HIPPO and prion disease signaling pathways. …”
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155por Ahmad, Fairus, Soelaiman, Ima Nirwana, Ramli, Elvy Suhana Mohd, Hooi, Tan Ming, Suhaimi, Farihah H“…INTRODUCTION: Prolonged steroid treatment administered to any patient can cause visceral obesity, which is associated with metabolic disease and Cushing's syndrome. Glucocorticoids have a profound negative effect on adipose tissue mass, giving rise to obesity, which in turn is regulated by the 11β-hydroxysteroid dehydrogenase type 1 enzyme. …”
Publicado 2011
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156por Sanches, Sarita A, Wiegers, Therese A, Otten, Barto J, Claahsen-van der Grinten, Hedi L“…BACKGROUND: Most research concerning congenital adrenal hyperplasia (CAH) and related conditions caused by primary adrenal insufficiency, such as Addison's or Cushing's disease, has focused on medical aspects rather than on patients' quality of life. …”
Publicado 2012
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157por Sbiera, Silviu, Tryfonidou, Marianna A., Weigand, Isabel, Grinwis, Guy C. M., Broeckx, Bart, Herterich, Sabine, Allolio, Bruno, Deutschbein, Timo, Fassnacht, Martin, Meij, Björn P.“…PURPOSE: Cushing’s disease (CD), also known as pituitary-dependent hyperadrenocorticism, is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary tumours. …”
Publicado 2016
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158por Kilani, Yassine, Mon, Aye Myat, Laxamana, Trisha, Kamal, Syeda Ashna Fatima, Zain, Rahul, Sohail, Haris, Yusuf, Mubarak H., Vargas-Jerez, Julia, Zahra, Tasneem“…The most commonly secreted hormone in ACC is cortisol, often presenting as a rapidly progressive Cushing syndrome (CS). We describe a case of ACC with an unusual presentation, mainly with psychiatric manifestations, including panic attacks and hallucinations. …”
Publicado 2022
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159por Zhao, Xiu, Xu, Zhongwei, Su, Huiping, Zheng, Rongfei, Zhan, Min, Huang, Yuge, Su, Zhe“…CASE PRESENTATION: Two siblings with infantile-onset PGGH were affected in this family. The main manifestations of patient 1 were typical Cushing’s syndrome-like manifestations, significantly aggravated symptoms after physiological doses of glucocorticoids and very low levels of serum cortisol and adrenocorticotropin hormone (ACTH) during attacks. …”
Publicado 2022
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160por Turla, Antonella, Laganà, Marta, Grisanti, Salvatore, Abate, Andrea, Ferrari, Vittorio Domenico, Cremaschi, Valentina, Sigala, Sandra, Consoli, Francesca, Cosentini, Deborah, Berruti, Alfredo“…METHODS: We describe the main side effects of the EDP-M scheme and the best way to manage them based on the experience of the Medical Oncology Unit of the Spedali Civili of Brescia. …”
Publicado 2022
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