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202381por Pei, Xiao M., Tam, Bjorn T., Sin, Thomas K., Wang, Feng F., Yung, Benjamin Y., Chan, Lawrence W., Wong, Cesar S., Ying, Michael, Lai, Christopher W., Siu, Parco M.“…The number of diabetic cancer patients is increasing but surprisingly the cardiac damaging effects of doxorubicin, a commonly used chemotherapeutic drug, on diabetic hearts have not been well-examined. …”
Publicado 2016
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202382por Pang, Yun, Tan, Ying, Li, Yongzhe, Zhang, Jianchun, Guo, Yongbing, Guo, Zhiling, Zhang, Chengying, Yu, Feng, Zhao, Ming-hui“…Lupus nephritis always elicits immune inflammatory tissue damages in kidney. Pentraxin 3 (PTX3), mainly produced at inflammatory sites, is known to be involved in the regulation of the innate immunity system. …”
Publicado 2016
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202383por Loviglio, Maria Nicla, Beck, Christine R., White, Janson J., Leleu, Marion, Harel, Tamar, Guex, Nicolas, Niknejad, Anne, Bi, Weimin, Chen, Edward S., Crespo, Isaac, Yan, Jiong, Charng, Wu-Lin, Gu, Shen, Fang, Ping, Coban-Akdemir, Zeynep, Shaw, Chad A., Jhangiani, Shalini N., Muzny, Donna M., Gibbs, Richard A., Rougemont, Jacques, Xenarios, Ioannis, Lupski, James R., Reymond, Alexandre“…METHODS: We investigated a cohort of 15 individuals with a clinical suspicion of SMS who showed neither deletion in the SMS critical region nor damaging variants in RAI1 using whole exome sequencing. …”
Publicado 2016
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202384por Kambouris, Marios, Thevenon, Julien, Soldatos, Ariane, Cox, Allison, Stephen, Joshi, Ben‐Omran, Tawfeg, Al‐Sarraj, Yasser, Boulos, Hala, Bone, William, Mullikin, James C., Masurel‐Paulet, Alice, St‐Onge, Judith, Dufford, Yannis, Chantegret, Corrine, Thauvin‐Robinet, Christel, Al‐Alami, Jamil, Faivre, Laurence, Riviere, Jean Baptiste, Gahl, William A., Bassuk, Alexander G., Malicdan, May Christine V., El‐Shanti, Hatem“…METHODS AND RESULTS: Homozygosity mapping and whole exome sequencing (WES) identified damaging homozygous variants in SCN10A, namely c.4514C>T; p.Thr1505Met in the first family and c.4735C>T; p.Arg1579* in the second family. …”
Publicado 2016
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202385por Heo, Won Il, Park, Kui Young, Jin, Taewon, Lee, Mi-Kyung, Kim, MinJeong, Choi, Eung Ho, Kim, Hae-Suk, Bae, Jung Min, Moon, Nam Ju, Seo, Seong Jun“…The relevance of the respective variants was supported by a program that could predict whether the mutations resulted in damaged protein function. Fourteen overlapping genes were identified during exome sequencing. …”
Publicado 2017
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202386por Bommer, Ulrich-Axel, Vine, Kara L., Puri, Prianka, Engel, Martin, Belfiore, Lisa, Fildes, Karen, Batterham, Marijka, Lochhead, Alistair, Aghmesheh, Morteza“…In colon cancer cells, expression of this protein is largely upregulated during treatment with the DNA-damaging anti-cancer drugs 5-FU and oxaliplatin, as part of the cellular stress response. …”
Publicado 2017
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202387por de Paula Simino, Laís Angélica, de Fante, Thaís, Figueiredo Fontana, Marina, Oliveira Borges, Fernanda, Torsoni, Márcio Alberto, Milanski, Marciane, Velloso, Lício Augusto, Souza Torsoni, Adriana“…Here we evaluated whether maternal HFD consumption during gestation and lactation could differently affect liver miR-122 and miR-370 expression leading to metabolic damages observed in offspring. Moreover, we investigate whether early overnutrition program offspring to more harmful response to HFD in later life. …”
Publicado 2017
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202388por Han, Qianpeng, Lin, Qiongyu, Huang, Peixian, Chen, Mengmeng, Hu, Xin, Fu, Hui, He, Shaoru, Shen, Fengcai, Zeng, Hongke, Deng, Yiyu“…By electron microscopy, some axons showed smaller diameter and thinner myelin sheath with damaged ultrastructure of node of Ranvier compared with the control rats. …”
Publicado 2017
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202389por Kreiner, Grzegorz, Rafa-Zabłocka, Katarzyna, Chmielarz, Piotr, Bagińska, Monika, Nalepa, Irena“…One of the drugs of potential interest for the treatment of HD is riluzole, which may act as a positive modulator of adult neurogenesis, promoting replacement of damaged MSNs. The aim of this study was to evaluate the effects of chronic riluzole treatment on a novel HD-like transgenic mouse model, based on the genetic ablation of the transcription factor TIF-IA. …”
Publicado 2017
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202390por Bazett, Mark, Biala, Agnieszka, Huff, Ryan D., Zeglinksi, Matthew R., Hansbro, Philip M., Bosiljcic, Momir, Gunn, Hal, Kalyan, Shirin, Hirota, Jeremy A.“…We hypothesized that KB, by re-directing damaging immune responses, would attenuate cigarette smoke-induced lung inflammation and bronchoalveolar (BAL) cytokine and chemokine production. …”
Publicado 2017
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202391por Xu, Hua-yan, Yang, Zhi-gang, Guo, Ying-kun, Shi, Ke, Liu, Xi, Zhang, Qin, Jiang, Li, Xie, Lin-jun“…BACKGROUND: Type 2 diabetes mellitus (DM2) may induce epicardial coronary artery diseases and left ventricular myocardial damaging as well. Left ventricular dysfunction was found in DM2. …”
Publicado 2017
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202392por Narang, Aarti, Qiao, Fei, Atkinson, Carl, Zhu, Hong, Yang, Xiaofeng, Kulik, Liudmila, Holers, V. Michael, Tomlinson, Stephen“…BACKGROUND: Natural IgM antibodies (Abs) function as innate immune sensors of injury via recognition of neoepitopes expressed on damaged cells, although how this recognition systems function following spinal cord injury (SCI) exposes various neoepitopes and their precise nature remains largely unknown. …”
Publicado 2017
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202393por Kuznetsova, Maria, Lopatnikova, Julia, Khantakova, Julia, Maksyutov, Rinat, Maksyutov, Amir, Sennikov, Sergey“…RESULTS: The resulting CTL populations were characterized by high contents of CD8(+) cells (71.5% in cultures of E88-specific T cells and 90.2% in cultures of E75-specific T cells) and displayed strong cytotoxic effects against the MCF-7 cell line (percentages of damaged tumor cells in samples under investigation were 60.2 and 65.7% for E88- and E75-specific T cells, respectively; level of spontaneous death of target cells was 17.9%). …”
Publicado 2017
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202394por Dwight, Trisha, Na, Un, Kim, Edward, Zhu, Ying, Richardson, Anne Louise, Robinson, Bruce G., Tucker, Katherine M., Gill, Anthony J., Benn, Diana E., Clifton-Bligh, Roderick J., Winge, Dennis R.“…In silico prediction tools suggest this variant is probably damaging to protein function, hence we assessed molecular and functional consequences of the resulting amino acid change (p.Phe53Leu) in yeast and human cells. …”
Publicado 2017
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202395“…BACKGROUND: Base excision repair (BER) pathway is a DNA repair pathway that is important in carcinogenesis and in response to DNA-damaging chemotherapy. XRCC1 is one of important molecular markers for BER. …”
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202396por Ramanantsoa, Ambinina, Wilson-Barthes, Marta, Rahenintsoa, Rindra, Hoibak, Sarah, Ranaivoharimina, Harilala, Rahelimalala, Martha Delphine, Rakotomanga, Avotiana, Finlay, Alyssa, Muela Ribera, Joan, Peeters Grietens, Koen“…Net owners reported feeling ashamed when presenting damaged nets in public for collection, leading to reduced net relinquishment. …”
Publicado 2017
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202397“…The median pHI by type was estimated to be one, zero and one respectively. The percentage of damaged nets increased after 12 months such that 83.5%, 74% and 68.5%, had holes. …”
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202398por Chen, Chih-Hung, Cheng, Ben-Chung, Chen, Kuan-Hung, Shao, Pei-Lin, Sung, Pei-Hsun, Chiang, Hsin-Ju, Yang, Chih-Chao, Lin, Kun-Chen, Sun, Cheuk-Kwan, Sheu, Jiunn-Jye, Chang, Hsueh-Wen, Lee, Mel S., Yip, Hon-Kan“…Protein expressions of inflammatory (MMP-9/TNF-α/NF-κB/IL-1ß/ICAM-1), oxidative-stress (NOX-1/NOX-2/oxidized protein), apoptotic (mitochondrial-Bax/cleaved-caspase-3/cleaved-PARP) and fibrotic/DNA-damaged (Smad3/TGF-ß/γ-H2AX) biomarkers showed an identical pattern, whereas anti-fibrotic (BMP-2/Smad1/5), anti-apoptotic/endothelial-integrity (Bcl-2/eNOS) and podocyte-integrity (ZO-1/p-cadherin) biomarkers exhibited an opposite pattern of kidney-injury score among the six groups (all P>0.0001). …”
Publicado 2017
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202399por Liu, Chen-Wei, Lee, Tzu-Lin, Chen, Yu-Chen, Liang, Chan-Jung, Wang, Shu-Huei, Lue, June-Horng, Tsai, Jaw-Shiun, Lee, Shih-Wei, Chen, Shun-Hua, Yang, Yi-Fan, Chuang, Tzu-Yi, Chen, Yuh-Lien“…Particulate matters (PMs) are major components of air pollution that damages lung cells. However, the mechanisms remain to be elucidated. …”
Publicado 2018
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202400por Leacock, Sophie, Syed, Parnayan, James, Victoria M., Bode, Anna, Kawakami, Koichi, Keramidas, Angelo, Suster, Maximiliano, Lynch, Joseph W., Harvey, Robert J.“…Further bioinformatic and mutagenesis analysis revealed an additional damaging substitution at K59 that ablates human GlyR α4 function, which is not present in other vertebrate GlyR α4 sequences. …”
Publicado 2018
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