“…Both Mt6 and D-Mt6 showed broad-spectrum antimicrobial activity, especially against A. baumannii, by damaging membrane integrity. Moreover, D-Mt6 showed better immunoregulatory activity against LPS induced inflammation through its LPS-neutralizing and suppression on MAPK signaling. …”
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“…The results of our studies showed that CHSB-AgNPs, especially at a concentration of 10 mg L(−1), strongly limited the vegetative mycelium growth of both species for short and long treatment times. The cell imaging revealed that CHSB-AgNPs damaged the conidia membranes and penetrated into the cells, while TCSB-AgNPs were deposited on their surface. …”
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“…Moreover, in recent literature, it has been established that SARS-CoV-2 is capable of directly damaging beta cells of the pancreas, thereby inducing new-onset diabetes in previously non-diabetics. …”
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“…Just under 60% of BTLO's anticipate a revenue loss of 10% or less, while about 10% expect a loss of more than 50%. The most damaging effects appear to have been experienced by competition enterprises. …”
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“…We determined fingolimod effects on the number and proportion of potentially CNS-damaging CD8(+)CD28(+) cytolytic T lymphocyte cells (CTLs) and on MS-depleted and dysfunctional CD8(+)CD28(−) anti-inflammatory suppressor/regulatory T cells (Treg) and on CD8(+) T-cell expression of the CD69 activation/lymph node retention protein in MS. …”
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“…Beyond these thresholds, osmoprotectants and antioxidant enzymes were seriously affected, Chl degradation intensified, the photosynthetic system was seriously damaged, and the growth of V. tricolor was severely affected. …”
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“…However, the blockage of the TRPC6 Ca(++) channel or the use of Ca(++) and Zn(++) chelators do not hinder HPF cytostatic/cytotoxic activity, suggesting that damages induced in melanoma cells may pass through other pathways. …”
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“…In addition, they are the most common vertebrate pests in European agriculture, causing extensive annual damages to a large variety of crops and exposing humans to an increased risk of pathogen transmission. …”
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“…BACKGROUND: Hydrocephalus is a neurological condition known to cause learning and memory disabilities due to its damaging effect on the hippocampal neurons, especially pyramidal neurons. …”
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“…The protein expressions of cell proliferation (PI3K/p-Akt/p-m-TOR/MMP-9/PrP(C)), cell cycle/mitophagy (cyclin-D1/clyclin-E1/ckd2/ckd4/PINK1), and cell stress (RAS/c-RAF/p-MEK1,2/p-ERK1,2) signaling were significantly, progressively reduced from groups one to four, whereas the protein expressions of apoptotic (Mit-Bax/cleaved-caspase-3/cleaved-PARP) and oxidative stress/mitochondrial damaged (NOX-1/NOX-2/cytosolic-cytochrome-C/p-DRP1) markers expressed an opposite pattern of cell proliferation signaling among the groups (all p < 0.0001). …”
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“…Notably, the present study also revealed that IFN-γ production by brain-resident cells also upregulates cerebral expressions of mRNA for the downregulatory molecules (IL-10, STAT3, SOCS1, CD274 [PD-L1], IL-27, and CD36), which can prevent overly stimulated IFN-γ-mediated pro-inflammatory responses and tissue damages. Thus, the present study uncovered the previously unrecognized the capability of IFN-γ production by brain-resident cells to upregulate expressions of a wide spectrum of molecules for coordinating both innate and T cell-mediated protective immunity with a fine-tuning regulation system to effectively control cerebral infection with T. gondii.…”
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“…The antioxidant enzyme activity of rice seedlings increased significantly after N application, which reduced the damaging effect of ROS (reactive oxygen species) to rice seedlings. …”
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“…BACKGROUND: Nurses have a high incidence of insomnia. Insomnia not only damages the physical and mental health of nurses, but also reduces their productivity and quality of care, ultimately affecting patient care. …”
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“…Mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) are promising candidates for therapies that repair damaged endometria. However, concerns about their efficacy are attributed to heterogeneity of the cell populations and EVs. …”
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“…Autophagy is a self-digestion process that is activated to remove damaged proteins for preventing cell death in response to various stresses. …”
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“…Different with neococcoids, Iceryini, a tribe in non-neococcoids including several damaging pests, has abdominal spiracles, compound eyes in males, relatively abundant wax, unique hermaphrodite system, and specific symbionts. …”
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“…Radiotherapy (RT) not only damages tumors but also induces interferon (IFN) expression in tumors. …”
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“…BACKGROUND: Venous leg ulcer(s) are common, recurring, open wounds on the lower leg, resulting from diseased or damaged leg veins impairing blood flow. Wound healing is the primary treatment aim for venous leg ulceration, alongside the management of pain, wound exudate and infection. …”
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