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  1. 202521
    “…However, it was verified a decrease in the intracellular calcium of the parasites, without significant pH variations of the acidocalcisomes. The intracellular damages were followed by an upregulation of the reactive oxygen species and ATP, but no depolarization effects were observed in the mitochondrial membrane potential. …”
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    Enyne acetogenins from Porcelia macrocarpa displayed anti-Trypanosoma cruzi activity and cause a reduction in the intracellular calcium level
  2. 202522
    “…Moreover, infused MSCs can be damaged by activated complement, yet strategies to minimise complement injury of hMSCs and improve their survival are limited. …”
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    Adipose tissue-derived human mesenchymal stromal cells can better suppress complement lysis, engraft and inhibit acute graft-versus-host disease in mice
  3. 202523
    “…RESULTS: The learning ability and spatial memory of 12-month-old APP/PS1 mice was severely damaged. The changes in cognitive function were only correlated with age and genotype, regardless of sex. …”
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    Age- and sex-related differences of periodontal bone resorption, cognitive function, and immune state in APP/PS1 murine model of Alzheimer’s disease
  4. 202524
    “…OBJECTIVES: This study aims to investigate the load-to-fracture of procedures changing crown-to-root ratio (R(CRR)) aimed to restore severely damaged upper central incisors to avoid tooth extraction compared to implant placement. …”
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    Effect of apical root resection, orthodontic extrusion, and surgical crown lengthening on load capability
  5. 202525
    “…Muse cells specifically home in damaged tissues where they exert pleiotropic effects. …”
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    Fetal Muse-based therapy prevents lethal radio-induced gastrointestinal syndrome by intestinal regeneration
  6. 202526
    por Ge, Rongguang, Chang, Jie, Cao, Yongjun
    Publicado 2023
    “…A previous study showed that the burden of headaches peaked at a working age that ranged from 15 to 49, particularly among females, affecting their productivity and severely damaging their social interactions. METHODS: The latest dataset was retrieved from the Global Burden of Disease (GBD) Study 2019. …”
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    Headache disorders and relevant sex and socioeconomic patterns in adolescents and young adults across 204 countries and territories: an updated global analysis
  7. 202527
    “…At the end of the nursery period, MIXED pigs fed LOW showed the highest number of aggressive behaviours around the feeder (interaction; p = 0.003) and pigs fed LOW showed more damaging behaviour (p < 0.001). CONCLUSIONS: Mixing animals at weaning had limited impact on growth performance but impaired welfare which was aggravated by energy and nutrient reduction in the nursery diet. …”
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    Effect of mixing at weaning and nutrient density of the weaner diet on growth performance and welfare of pigs to slaughter
  8. 202528
    “…Immunofluorescence and TEM analyses revealed that the deletion of ACTL7A damaged the formation of acrosome-acroplaxome-manchette complex, leading to abnormalities in the shaping of sperm heads. …”
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    Loss of ACTL7A causes small head sperm by defective acrosome-acroplaxome-manchette complex
  9. 202529
    “…The current situation is that vaccine prevention has not met expectations, and emergency containment strategies following outbreaks cannot prevent the damages and losses already incurred. Therefore, a more sensitive detection method, that is both convenient and enables accurate and effective sequencing, that will provide early warning of PEDV and PDCoV is necessary. …”
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    A duplex nested RT-PCR method for monitoring porcine epidemic diarrhea virus and porcine delta-coronavirus
  10. 202530
    “…When the heart muscle is damaged, it is released into the blood and can be detected. …”
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    Development of an ID-LC–MS/MS method using targeted proteomics for quantifying cardiac troponin I in human serum
  11. 202531
    “…It seems that altered lunge landing biomechanics may increase the risk of ankle and knee injuries and muscular damages in amateur athletes. It is recommended for amateur players to follow a injury prevention training program that promotes proper lunging technique. …”
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    Comparison of mechanical energy transfer during right-forward lunge between female amateur and professional badminton players
  12. 202532
    “…During brain neuron inflammation, the organism activates and stimulates the neuron rescue through the enrichment of the old neuron microenvironment with growth factors such as GDNF, BDNF, SOX1/2, and MAPK secreted by the surrounding neurons and glial cells to maintain the damaged neuron by inflammation alive even if the axon is dead. …”
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    Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation
  13. 202533
    “…BACKGROUND: Ticks are ectoparasites capable of directly damaging their hosts and transmitting vector-borne diseases. …”
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    Transcriptome analysis of Haemaphysalis flava female using Illumina HiSeq 4000 sequencing: de novo assembly, functional annotation and discovery of SSR markers
  14. 202534
    “…However, an increase in structurally damaged nSCs was seen in individuals with diabetic polyneuropathy. …”
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    Structural changes in Schwann cells and nerve fibres in type 1 diabetes: relationship with diabetic polyneuropathy
  15. 202535
    “…Studies have shown that far red prolonged hypocotyl 3 (FHY3) and far red damaged response (FAR1) play important roles in plant growth, light response, and resistance. …”
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    Genome-wide identification and molecular expression profile analysis of FHY3/FAR1 gene family in walnut (Juglans sigillata L.) development
  16. 202536
    “…BACKGROUND: Alcohol use disorder (AUD) has a negative impact on one’s health and wastes a lot of societal resources since it damages one’s brain tissue. Yet the knowledge of the neural mechanisms underlying alcohol addiction still remains limited. …”
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    Alterations of brain activity in patients with alcohol use disorder: a resting-state fMRI study
  17. 202537
    por Davies, Joanna M. S., Cillard, Josiane, Friguet, Bertrand, Cadenas, Enrique, Cadet, Jean, Cayce, Rachael, Fishmann, Andrew, Liao, David, Bulteau, Anne-Laure, Derbré, Frédéric, Rébillard, Amélie, Burstein, Steven, Hirsch, Etienne, Kloner, Robert A., Jakowec, Michael, Petzinger, Giselle, Sauce, Delphine, Sennlaub, Florian, Limon, Isabelle, Ursini, Fulvio, Maiorino, Matilde, Economides, Christina, Pike, Christian J., Cohen, Pinchas, Salvayre, Anne Negre, Halliday, Matthew R., Lundquist, Adam J., Jakowec, Nicolaus A., Mechta-Grigoriou, Fatima, Mericskay, Mathias, Mariani, Jean, Li, Zhenlin, Huang, David, Grant, Ellsworth, Forman, Henry J., Finch, Caleb E., Sun, Patrick Y., Pomatto, Laura C. D., Agbulut, Onnik, Warburton, David, Neri, Christian, Rouis, Mustapha, Cillard, Pierre, Capeau, Jacqueline, Rosenbaum, Jean, Davies, Kelvin J. A.
    Publicado 2017
    “…Clin Sci (Lond) 131(21):2573–2599, 2017; Pomatto and Davies 2017); the non-damaging process by which an apparent toxicant can activate biological signal transduction pathways to increase expression of protective genes, by mechanisms that are completely different from those by which the same agent induces toxicity at high concentrations. …”
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    The Oxygen Paradox, the French Paradox, and age-related diseases
  18. 202538
    por Hauke, Jan, Horvath, Judit, Groß, Eva, Gehrig, Andrea, Honisch, Ellen, Hackmann, Karl, Schmidt, Gunnar, Arnold, Norbert, Faust, Ulrike, Sutter, Christian, Hentschel, Julia, Wang‐Gohrke, Shan, Smogavec, Mateja, Weber, Bernhard H. F., Weber‐Lassalle, Nana, Weber‐Lassalle, Konstantin, Borde, Julika, Ernst, Corinna, Altmüller, Janine, Volk, Alexander E., Thiele, Holger, Hübbel, Verena, Nürnberg, Peter, Keupp, Katharina, Versmold, Beatrix, Pohl, Esther, Kubisch, Christian, Grill, Sabine, Paul, Victoria, Herold, Natalie, Lichey, Nadine, Rhiem, Kerstin, Ditsch, Nina, Ruckert, Christian, Wappenschmidt, Barbara, Auber, Bernd, Rump, Andreas, Niederacher, Dieter, Haaf, Thomas, Ramser, Juliane, Dworniczak, Bernd, Engel, Christoph, Meindl, Alfons, Schmutzler, Rita K., Hahnen, Eric
    Publicado 2018
    “…Compared with control datasets, predicted damaging rare missense variants were significantly more prevalent in CHEK2 and TP53 in BC index patients. …”
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    Gene panel testing of 5589 BRCA1/2‐negative index patients with breast cancer in a routine diagnostic setting: results of the German Consortium for Hereditary Breast and Ovarian Cancer
  19. 202539
    “…Among all the patients, 155 (68.6%) had at least one coexisting disease, and their sequential organ failure assessment score was 4 (2–8). Organ function damages were found in most of the patients: ARDS in 161 (71.2%) patients, septic shock in 34 (15.0%) patients, acute kidney injury occurred in 57 (25.2%) patients, cardiac injury in 61 (27.0%) patients, and lymphocytopenia in 160 (70.8%) patients. …”
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    Patients with COVID-19 in 19 ICUs in Wuhan, China: a cross-sectional study
  20. 202540
    “…By regulating microglial activity, CX3CL1 can mitigate the damaging effects of chronic microglial inflammation within the brain, a state that plays a major role in aging and neurodegeneration. …”
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    Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice
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