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202521por Thevenard, Fernanda, Brito, Ivanildo A., Costa-Silva, Thais A., Tempone, Andre G., Lago, João Henrique G.“…However, it was verified a decrease in the intracellular calcium of the parasites, without significant pH variations of the acidocalcisomes. The intracellular damages were followed by an upregulation of the reactive oxygen species and ATP, but no depolarization effects were observed in the mitochondrial membrane potential. …”
Publicado 2023
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202522por Wu, Stanley Chun Ming, Zhu, Manyu, Chik, Stanley C. C., Kwok, Maxwell, Javed, Asif, Law, Laalaa, Chan, Shing, Boheler, Kenneth R., Liu, Yin Ping, Chan, Godfrey Chi Fung, Poon, Ellen Ngar-Yun“…Moreover, infused MSCs can be damaged by activated complement, yet strategies to minimise complement injury of hMSCs and improve their survival are limited. …”
Publicado 2023
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202523por Chen, Huiwen, Liao, Yue, Zhang, Xu, Shen, Hui, Shang, Dihua, He, Zhiyan, Zhou, Wei, Song, Zhongchen“…RESULTS: The learning ability and spatial memory of 12-month-old APP/PS1 mice was severely damaged. The changes in cognitive function were only correlated with age and genotype, regardless of sex. …”
Publicado 2023
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202524por Naumann, M., Adali, U., Rosentritt, M., Happe, A., Frankenberger, R., Sterzenbach, G.“…OBJECTIVES: This study aims to investigate the load-to-fracture of procedures changing crown-to-root ratio (R(CRR)) aimed to restore severely damaged upper central incisors to avoid tooth extraction compared to implant placement. …”
Publicado 2023
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202525por Dushime, Honorine, Moreno, Stéphanie G., Linard, Christine, Adrait, Annie, Couté, Yohann, Peltzer, Juliette, Messiaen, Sébastien, Torres, Claire, Bensemmane, Lydia, Lewandowski, Daniel, Romeo, Paul-Henri, Petit, Vanessa, Gault, Nathalie“…Muse cells specifically home in damaged tissues where they exert pleiotropic effects. …”
Publicado 2023
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202526“…A previous study showed that the burden of headaches peaked at a working age that ranged from 15 to 49, particularly among females, affecting their productivity and severely damaging their social interactions. METHODS: The latest dataset was retrieved from the Global Burden of Disease (GBD) Study 2019. …”
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202527por González-Solé, Francesc, Camp Montoro, Jordi, Solà-Oriol, David, Pérez, José Francisco, Lawlor, Peadar G., Boyle, Laura A., Garcia Manzanilla, Edgar“…At the end of the nursery period, MIXED pigs fed LOW showed the highest number of aggressive behaviours around the feeder (interaction; p = 0.003) and pigs fed LOW showed more damaging behaviour (p < 0.001). CONCLUSIONS: Mixing animals at weaning had limited impact on growth performance but impaired welfare which was aggravated by energy and nutrient reduction in the nursery diet. …”
Publicado 2023
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202528por Zhang, Yini, Tang, Jianan, Wang, Xuemei, Sun, Yisi, Yang, Tianying, Shen, Xiaorong, Yang, Xinyue, Shi, Huijuan, Sun, Xiaoxi, Xin, Aijie“…Immunofluorescence and TEM analyses revealed that the deletion of ACTL7A damaged the formation of acrosome-acroplaxome-manchette complex, leading to abnormalities in the shaping of sperm heads. …”
Publicado 2023
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202529por Li, Chun Qi, Hu, Li Qun, Liu, Guo Ping, Wang, Yan, Li, Tong, Chen, Shao Xian, Yang, Xiao Lin, Ma, Li Xin, Zeng, Jian Guo“…The current situation is that vaccine prevention has not met expectations, and emergency containment strategies following outbreaks cannot prevent the damages and losses already incurred. Therefore, a more sensitive detection method, that is both convenient and enables accurate and effective sequencing, that will provide early warning of PEDV and PDCoV is necessary. …”
Publicado 2023
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202530“…When the heart muscle is damaged, it is released into the blood and can be detected. …”
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202531“…It seems that altered lunge landing biomechanics may increase the risk of ankle and knee injuries and muscular damages in amateur athletes. It is recommended for amateur players to follow a injury prevention training program that promotes proper lunging technique. …”
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202532por Kanwore, Kouminin, Kanwore, Konimpo, Guo, Xiaoxiao, Xia, Ying, Zhou, Han, Zhang, Lin, Adzika, Gabriel Komla, Joseph, Adu-Amankwaah, Abiola, Ayanlaja Abdulrahman, Mu, Peipei, Kambey, Piniel Alphayo, Noah, Marie Louis N’dzie, Gao, DianShuai“…During brain neuron inflammation, the organism activates and stimulates the neuron rescue through the enrichment of the old neuron microenvironment with growth factors such as GDNF, BDNF, SOX1/2, and MAPK secreted by the surrounding neurons and glial cells to maintain the damaged neuron by inflammation alive even if the axon is dead. …”
Publicado 2023
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202533por Sang, Min Kyu, Patnaik, Hongray Howrelia, Park, Jie Eun, Song, Dae Kwon, Jeong, Jun Yang, Hong, Chan Eui, Kim, Yong Tae, Shin, Hyeon Jun, Ziwei, Liu, Hwang, Hee Ju, Park, So Young, Kang, Se Won, Park, Seung-Hwan, Cha, Sung-Jae, Ko, Jung Ho, Shin, E. Hyun, Park, Hong Seog, Jo, Yong Hun, Han, Yeon Soo, Patnaik, Bharat Bhusan, Lee, Yong Seok“…BACKGROUND: Ticks are ectoparasites capable of directly damaging their hosts and transmitting vector-borne diseases. …”
Publicado 2023
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202534por Hu, Xiaoli, Buhl, Christian Selmer, Sjogaard, Marie Balle, Schousboe, Karoline, Mizrak, Hatice Isik, Kufaishi, Huda, Jensen, Troels Staehelin, Hansen, Christian Stevns, Yderstræde, Knud Bonnet, Zhang, Ming-Dong, Ernfors, Patrik, Nyengaard, Jens Randel, Karlsson, Pall“…However, an increase in structurally damaged nSCs was seen in individuals with diabetic polyneuropathy. …”
Publicado 2023
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202535por Chen, Shengqun, Chen, Yingfu, Liang, Mei, Qu, Shuang, Shen, Lianwen, Zeng, Yajun, Hou, Na“…Studies have shown that far red prolonged hypocotyl 3 (FHY3) and far red damaged response (FAR1) play important roles in plant growth, light response, and resistance. …”
Publicado 2023
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202536“…BACKGROUND: Alcohol use disorder (AUD) has a negative impact on one’s health and wastes a lot of societal resources since it damages one’s brain tissue. Yet the knowledge of the neural mechanisms underlying alcohol addiction still remains limited. …”
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202537por Davies, Joanna M. S., Cillard, Josiane, Friguet, Bertrand, Cadenas, Enrique, Cadet, Jean, Cayce, Rachael, Fishmann, Andrew, Liao, David, Bulteau, Anne-Laure, Derbré, Frédéric, Rébillard, Amélie, Burstein, Steven, Hirsch, Etienne, Kloner, Robert A., Jakowec, Michael, Petzinger, Giselle, Sauce, Delphine, Sennlaub, Florian, Limon, Isabelle, Ursini, Fulvio, Maiorino, Matilde, Economides, Christina, Pike, Christian J., Cohen, Pinchas, Salvayre, Anne Negre, Halliday, Matthew R., Lundquist, Adam J., Jakowec, Nicolaus A., Mechta-Grigoriou, Fatima, Mericskay, Mathias, Mariani, Jean, Li, Zhenlin, Huang, David, Grant, Ellsworth, Forman, Henry J., Finch, Caleb E., Sun, Patrick Y., Pomatto, Laura C. D., Agbulut, Onnik, Warburton, David, Neri, Christian, Rouis, Mustapha, Cillard, Pierre, Capeau, Jacqueline, Rosenbaum, Jean, Davies, Kelvin J. A.“…Clin Sci (Lond) 131(21):2573–2599, 2017; Pomatto and Davies 2017); the non-damaging process by which an apparent toxicant can activate biological signal transduction pathways to increase expression of protective genes, by mechanisms that are completely different from those by which the same agent induces toxicity at high concentrations. …”
Publicado 2017
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202538por Hauke, Jan, Horvath, Judit, Groß, Eva, Gehrig, Andrea, Honisch, Ellen, Hackmann, Karl, Schmidt, Gunnar, Arnold, Norbert, Faust, Ulrike, Sutter, Christian, Hentschel, Julia, Wang‐Gohrke, Shan, Smogavec, Mateja, Weber, Bernhard H. F., Weber‐Lassalle, Nana, Weber‐Lassalle, Konstantin, Borde, Julika, Ernst, Corinna, Altmüller, Janine, Volk, Alexander E., Thiele, Holger, Hübbel, Verena, Nürnberg, Peter, Keupp, Katharina, Versmold, Beatrix, Pohl, Esther, Kubisch, Christian, Grill, Sabine, Paul, Victoria, Herold, Natalie, Lichey, Nadine, Rhiem, Kerstin, Ditsch, Nina, Ruckert, Christian, Wappenschmidt, Barbara, Auber, Bernd, Rump, Andreas, Niederacher, Dieter, Haaf, Thomas, Ramser, Juliane, Dworniczak, Bernd, Engel, Christoph, Meindl, Alfons, Schmutzler, Rita K., Hahnen, Eric“…Compared with control datasets, predicted damaging rare missense variants were significantly more prevalent in CHEK2 and TP53 in BC index patients. …”
Publicado 2018
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202539por Yu, Yuan, Xu, Dan, Fu, Shouzhi, Zhang, Jun, Yang, Xiaobo, Xu, Liang, Xu, Jiqian, Wu, Yongran, Huang, Chaolin, Ouyang, Yaqi, Yang, Luyu, Fang, Minghao, Xiao, Hongwen, Ma, Jing, Zhu, Wei, Hu, Song, Hu, Quan, Ding, Daoyin, Hu, Ming, Zhu, Guochao, Xu, Weijiang, Guo, Jun, Xu, Jinglong, Yuan, Haitao, Zhang, Bin, Yu, Zhui, Chen, Dechang, Yuan, Shiying, Shang, You“…Among all the patients, 155 (68.6%) had at least one coexisting disease, and their sequential organ failure assessment score was 4 (2–8). Organ function damages were found in most of the patients: ARDS in 161 (71.2%) patients, septic shock in 34 (15.0%) patients, acute kidney injury occurred in 57 (25.2%) patients, cardiac injury in 61 (27.0%) patients, and lymphocytopenia in 160 (70.8%) patients. …”
Publicado 2020
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202540por Winter, Aimee N., Subbarayan, Meena S., Grimmig, Bethany, Weesner, Jason A., Moss, Lauren, Peters, Melinda, Weeber, Edwin, Nash, Kevin, Bickford, Paula C.“…By regulating microglial activity, CX3CL1 can mitigate the damaging effects of chronic microglial inflammation within the brain, a state that plays a major role in aging and neurodegeneration. …”
Publicado 2020
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