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202541por Krushkal, Julia, Silvers, Thomas, Reinhold, William C., Sonkin, Dmitriy, Vural, Suleyman, Connelly, John, Varma, Sudhir, Meltzer, Paul S., Kunkel, Mark, Rapisarda, Annamaria, Evans, David, Pommier, Yves, Teicher, Beverly A.“…Increased promoter methylation of SLFN11 was correlated with resistance to DNA damaging agents, as a result of low or no SLFN11 expression. …”
Publicado 2020
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202542por Utsumi, Yusuke, Nemoto, Harumi, Nakaya, Naoki, Nakamura, Tomohiro, Tsuchiya, Naho, Narita, Akira, Kogure, Mana, Suzuki, Tomomi, Seto, Moe, Katayanagi, Mitsuaki, Okuyama, Junko, Sakuma, Atsushi, Honda, Nami, Sugawara, Yumi, Kaye-Kauderer, Halley, Takahashi, Yuta, Kayama, Akemi, Kakuto, Yoshihisa, Kohzuki, Masahiro, Hozawa, Atsushi, Tsuji, Ichiro, Tomita, Hiroaki“…METHODS: Participants included individuals over 20 years of age (N = 718) from Shichigahama town in Miyagi prefecture, whose houses were significantly damaged by the GEJE. Their mental health conditions were assessed by the Kessler Psychological Distress Scale (K6), the Center for Epidemiologic Studies Depression Scale (CES-D), and the Impact of Event Scale-Revised (IES-R). …”
Publicado 2020
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202543por Liu, Xianxian, Lai, Hua, Zeng, Xiaoming, Xin, Siming, Nie, Liju, Liang, Zhenyi, Wu, Meiling, Chen, Yu, Zheng, Jiusheng, Zou, Yang“…Moreover, the influences of all the mutations on protein function were predicted to be damaging by the SIFT tool. Combining clinical data, it was found that the mutation group (93.36 µmol/L) had significantly (P = 0.038) higher total bile acid (TBA) levels than the wild-type group (40.81 µmol/L). …”
Publicado 2020
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202544por Namjou, Bahram, Stanaway, Ian B., Lingren, Todd, Mentch, Frank D., Benoit, Barbara, Dikilitas, Ozan, Niu, Xinnan, Shang, Ning, Shoemaker, Ashley H., Carey, David J., Mirshahi, Tooraj, Singh, Rajbir, Nestor, Jordan G., Hakonarson, Hakon, Denny, Joshua C., Crosslin, David R., Jarvik, Gail P., Kullo, Iftikhar J., Williams, Marc S., Harley, John B.“…RESULTS: Targeted sequencing data of MC4R revealed 125 coding variants in 1839 eMERGE participants including 30 unreported coding variants that were predicted to be functionally damaging. Highly penetrant unreported variants included (L325I, E308K, D298N, S270F, F261L, T248A, D111V, and Y80F) in which seven participants had obesity class III defined as BMI ≥ 40 kg/m(2). …”
Publicado 2020
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202545por Adane, Mesafint Molla, Alene, Getu Degu, Mereta, Seid Tiku, Wanyonyi, Kristina L.“…Children are uniquely vulnerable and sensitive to the damaging health effects of household air pollution which includes childhood acute lower respiratory infection (ALRI). …”
Publicado 2021
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202546“…Preoperative course, age, sex, bone mineral density, damaged segment, anterior vertebral height, vertebral compression rate, Cobb angle, visual analogue scale and Oswestry dysfunction index were compared between the two groups. …”
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202547por Li, Shulin, Wang, Yanping, Wang, Zhuojun, Chen, Lu, Zuo, Bangjie, Liu, Caixia, Sun, Dong“…The ability of GFP-AMSCs and GDNF-AMSCs supernatants to promote tube formation of endothelial cells, repair damaged endothelial cell junctions, and improve endothelial cell function was compared by using tube formation assay, immunofluorescence techniques, and vascular ring assay, respectively. …”
Publicado 2021
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202548por Ruwanpathirana, Gihan P., Plett, Darren C., Williams, Robert C., Davey, Catherine E., Johnston, Leigh A., Kronzucker, Herbert J.“…Sodium is one of the most damaging ions to the growth and productivity of crops. …”
Publicado 2021
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202549por Hanscom, Marie, Loane, David J., Aubretch, Taryn, Leser, Jenna, Molesworth, Kara, Hedgekar, Nivedita, Ritzel, Rodney M., Abulwerdi, Gelareh, Shea-Donohue, Terez, Faden, Alan I.“…Enteric pathogen infection during chronic TBI worsened cortical lesion volume; however, the pathophysiological mechanisms underlying the damaging effects of enteric challenge during chronic TBI remain unknown. …”
Publicado 2021
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202550por Li, Hongmei, Hu, Bowen, Hu, Shang, Luo, Wen, Sun, Donglei, Yang, Minmin, Liao, Zhiying, Wei, Haohui, Zhao, Changbin, Li, Dajian, Shi, Meiqing, Luo, Qingbin, Zhang, Dexiang, Nie, Qinghua, Zhang, Xiquan“…Moreover, mitochondrial function in the HSCs of RSS-SLD chickens was damaged, including an increase in ROS production, decrease in ATP concentration, and decrease in mitochondrial membrane potential (ΔΨm). …”
Publicado 2021
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202551por Delorey, Toni M., Ziegler, Carly G. K., Heimberg, Graham, Normand, Rachelly, Yang, Yiming, Segerstolpe, Asa, Abbondanza, Domenic, Fleming, Stephen J., Subramanian, Ayshwarya, Montoro, Daniel T., Jagadeesh, Karthik A., Dey, Kushal K., Sen, Pritha, Slyper, Michal, Pita-Juárez, Yered H., Phillips, Devan, Bloom-Ackerman, Zohar, Barkas, Nick, Ganna, Andrea, Gomez, James, Normandin, Erica, Naderi, Pourya, Popov, Yury V., Raju, Siddharth S., Niezen, Sebastian, Tsai, Linus T.-Y., Siddle, Katherine J., Sud, Malika, Tran, Victoria M., Vellarikkal, Shamsudheen K., Amir-Zilberstein, Liat, Atri, Deepak S., Beechem, Joseph, Brook, Olga R., Chen, Jonathan, Divakar, Prajan, Dorceus, Phylicia, Engreitz, Jesse M., Essene, Adam, Fitzgerald, Donna M., Fropf, Robin, Gazal, Steven, Gould, Joshua, Grzyb, John, Harvey, Tyler, Hecht, Jonathan, Hether, Tyler, Jane-Valbuena, Judit, Leney-Greene, Michael, Ma, Hui, McCabe, Cristin, McLoughlin, Daniel E., Miller, Eric M., Muus, Christoph, Niemi, Mari, Padera, Robert, Pan, Liuliu, Pant, Deepti, Pe’er, Carmel, Pfiffner-Borges, Jenna, Pinto, Christopher J., Plaisted, Jacob, Reeves, Jason, Ross, Marty, Rudy, Melissa, Rueckert, Erroll H., Siciliano, Michelle, Sturm, Alexander, Todres, Ellen, Waghray, Avinash, Warren, Sarah, Zhang, Shuting, Zollinger, Daniel R., Cosimi, Lisa, Gupta, Rajat M., Hacohen, Nir, Hide, Winston, Price, Alkes L., Rajagopal, Jayaraj, Tata, Purushothama Rao, Riedel, Stefan, Szabo, Gyongyi, Tickle, Timothy L., Hung, Deborah, Sabeti, Pardis C., Novak, Richard, Rogers, Robert, Ingber, Donald E., Jiang, Z. Gordon, Juric, Dejan, Babadi, Mehrtash, Farhi, Samouil L., Stone, James R., Vlachos, Ioannis S., Solomon, Isaac H., Ashenberg, Orr, Porter, Caroline B.M., Li, Bo, Shalek, Alex K., Villani, Alexandra-Chloé, Rozenblatt-Rosen, Orit, Regev, Aviv“…We observed evidence of: alveolar type 2 (AT2) differentiation replacing depleted alveolar type 1 (AT1) lung epithelial cells, as previously seen in fibrosis; a concomitant increase in myofibroblasts reflective of defective tissue repair; and, putative TP63(+) intrapulmonary basal-like progenitor (IPBLP) cells, similar to cells identified in H1N1 influenza, that may serve as an emergency cellular reserve for severely damaged alveoli. Together, these findings suggest the activation and failure of multiple avenues for regeneration of the epithelium in these terminal lungs. …”
Publicado 2021
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202552por Abd El-Aziz, Norhan K., Ammar, Ahmed M., El-Naenaeey, El-sayed Y. M., El Damaty, Hend M., Elazazy, Asmaa A., Hefny, Ahmed A., Shaker, Asmaa, Eldesoukey, Ibrahim E.“…Scanning electron microscope (SEM) analysis revealed that biofilms of S. agalactiae isolates treated with cinnamon oil were more seriously damaged than observed in AgNPs cinnamon oil combination. …”
Publicado 2021
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202553por Zhang, Yan, Li, Di, Zeng, Qiuming, Feng, Jianbo, Fu, Haijuan, Luo, Zhaohui, Xiao, Bo, Yang, Huan, Wu, Minghua“…Ectopic expression of LRRC4 alleviates the clinical symptoms of EAE mice and protects the neurons from immune damages. CONCLUSIONS: We identified a neuroprotective role of LRRC4 in the progression of EAE, which may be used as a potential target for auxiliary support therapeutic treatment of MS. …”
Publicado 2021
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202554por Ruigrok, Eline A. M., van Vliet, Nicole, Dalm, Simone U., de Blois, Erik, van Gent, Dik C., Haeck, Joost, de Ridder, Corrina, Stuurman, Debra, Konijnenberg, Mark W., van Weerden, Wytske M., de Jong, Marion, Nonnekens, Julie“…PURPOSE: Various radiolabeled prostate-specific membrane antigen (PSMA)–targeting tracers are clinically applied for prostate cancer (PCa) imaging and targeted radionuclide therapy. The PSMA binding affinities, biodistribution, and DNA-damaging capacities of these radiotracers have not yet been compared in detail. …”
Publicado 2020
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202555por Sankpal, Narendra V., Brown, Taylor C., Fleming, Timothy P., Herndon, John M., Amaravati, Anusha A., Loynd, Allison N., Gillanders, William E.“…To determine how EpCAM mutations affect cancer biology we studied C66Y, a damaging TY-1 domain mutation identified in liver cancer, as well as 13 other cancer-associated EpCAM mutations. …”
Publicado 2021
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202556por McAvoy, Malia, Bui, Ai-Tram N., Hansen, Christopher, Plana, Deborah, Said, Jordan T., Yu, Zizi, Yang, Helen, Freake, Jacob, Van, Christopher, Krikorian, David, Cramer, Avilash, Smith, Leanne, Jiang, Liwei, Lee, Karen J., Li, Sara J., Beller, Brandon, Huggins, Kimberley, Short, Michael P., Yu, Sherry H., Mostaghimi, Arash, Sorger, Peter K., LeBoeuf, Nicole R.“…The purpose of this study was to develop an inexpensive frame for damaged and poorly fitting masks using readily available materials and 3D printing. …”
Publicado 2021
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202557por Qamar, Zahida, Nasir, Idrees Ahmad, Abouhaidar, Mounir G., Hefferon, Kathleen L., Rao, Abdul Qayyum, Latif, Ayesha, Ali, Qurban, Anwar, Saima, Rashid, Bushra, Shahid, Ahmad Ali“…Quality and yield of sugarcane production is always threatened by the damages of cane borers and weeds. In current study two problems were better addressed through the genetic modification of sugarcane for provision of resistance against insects and weedicide via the expression of two modified cane borer resistant CEMB-Cry1Ac (1.8 kb), CEMB-Cry2A (1.9 kb) and one glyphosate tolerant CEMB-GTGene (1.4 kb) genes, driven by maize Ubiquitin Promoter and nos terminator. …”
Publicado 2021
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202558por de Filippis, Anna, D’Agostino, Antonella, Pirozzi, Anna Virginia Adriana, Tufano, Maria Antonietta, Schiraldi, Chiara, Baroni, Adone“…Device application aimed at enhancing skin ability to reconstruct its damaged sites through a proper dermal regenerative process. …”
Publicado 2020
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202559“…AD is characterized by damaged epidermal barrier, xerosis and pruritus of eczematous skin lesions which tend to flare. …”
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202560por Sun, Shihang, Lin, Miaomiao, Qi, Xiujuan, Chen, Jinyong, Gu, Hong, Zhong, Yunpeng, Sun, Leiming, Muhammad, Abid, Bai, Danfeng, Hu, Chungen, Fang, Jinbao“…Moreover, starch and sucrose metabolism may be the key pathway for tolerant kiwifruit to resist low temperature damages. These results increase our understanding of the complex mechanisms involved in the freezing tolerance of kiwifruit under cold stress and reveal a series of candidate genes for use in breeding new cultivars with enhanced freezing tolerance. …”
Publicado 2021
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