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202581por Puuvuori, Emmi, Liggieri, Francesco, Velikyan, Irina, Chiodaroli, Elena, Sigfridsson, Jonathan, Romelin, Hampus, Ingvast, Sofie, Korsgren, Olle, Hulsart-Billström, Gry, Perchiazzi, Gaetano, Eriksson, Olof“…The tracer uptake corresponded to the damaged areas assessed by CT and histology and were in line with HU quantification. …”
Publicado 2022
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202582por Zhu, Jiang, Pittman, Sara, Dhavale, Dhruva, French, Rachel, Patterson, Jessica N., Kaleelurrrahuman, Mohamed Salman, Sun, Yuanzi, Vaquer-Alicea, Jaime, Maggiore, Gianna, Clemen, Christoph S., Buscher, William J., Bieschke, Jan, Kotzbauer, Paul, Ayala, Yuna, Diamond, Marc I., Davis, Albert A., Weihl, Conrad“…VCP facilitates the clearance of damaged lysosomes via lysophagy. We propose that VCP’s surveillance of permeabilized endosomes may protect against the proteopathic spread of pathogenic protein aggregates. …”
Publicado 2022
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202583por Zhu, Chunhui, Zhao, Ying, Pei, Dandan, Liu, Zhongbo, Liu, Jin, Li, Ye, Yu, Shuchen, Ma, Lingyan, Sun, Junyi, Li, Ang“…BACKGROUND: Oxidative stress mediated by hyperglycemia damages cell-reparative processes such as mitophagy. …”
Publicado 2022
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202584por Hu, Junwen, Li, Yin, Li, Zhaoqing, Chen, Jingyin, Cao, Yang, Xu, Duo, Zheng, Leilei, Bai, Ruiliang, Wang, Lin“…METHODS: We collected structural images, resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging for each subject. …”
Publicado 2022
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202585por Stokes, Jonathan, Turner, Alex James, Anselmi, Laura, Morciano, Marcello, Hone, Thomas“…Within ‘compulsory’ settings, such as schools and workplaces, less damaging interventions than closing might also be considered in future waves/epidemics. …”
Publicado 2022
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202586Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidatepor Mishra, Aniket, Duplaà, Cécile, Vojinovic, Dina, Suzuki, Hideaki, Sargurupremraj, Muralidharan, Zilhão, Nuno R, Li, Shuo, Bartz, Traci M, Jian, Xueqiu, Zhao, Wei, Hofer, Edith, Wittfeld, Katharina, Harris, Sarah E, van der Auwera-Palitschka, Sandra, Luciano, Michelle, Bis, Joshua C, Adams, Hieab H H, Satizabal, Claudia L, Gottesman, Rebecca F, Gampawar, Piyush G, Bülow, Robin, Weiss, Stefan, Yu, Miao, Bastin, Mark E, Lopez, Oscar L, Vernooij, Meike W, Beiser, Alexa S, Völker, Uwe, Kacprowski, Tim, Soumare, Aicha, Smith, Jennifer A, Knopman, David S, Morris, Zoe, Zhu, Yicheng, Rotter, Jerome I, Dufouil, Carole, Valdés Hernández, Maria, Muñoz Maniega, Susana, Lathrop, Mark, Boerwinkle, Erik, Schmidt, Reinhold, Ihara, Masafumi, Mazoyer, Bernard, Yang, Qiong, Joutel, Anne, Tournier-Lasserve, Elizabeth, Launer, Lenore J, Deary, Ian J, Mosley, Thomas H, Amouyel, Philippe, DeCarli, Charles S, Psaty, Bruce M, Tzourio, Christophe, Kardia, Sharon L R, Grabe, Hans J, Teumer, Alexander, van Duijn, Cornelia M, Schmidt, Helena, Wardlaw, Joanna M, Ikram, M Arfan, Fornage, Myriam, Gudnason, Vilmundur, Seshadri, Sudha, Matthews, Paul M, Longstreth, William T, Couffinhal, Thierry, Debette, Stephanie“…The whole-exome association study identified significant associations of extreme small vessel disease with common variants in the 5′ UTR region of EFEMP1 (chr2p16.1) and one probably damaging common missense variant in TRIM47 (chr17q25.1). …”
Publicado 2022
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202587por Bejoy, Julie, Farry, Justin M., Peek, Jennifer L., Cabatu, Mariana C., Williams, Felisha M., Welch, Richard C., Qian, Eddie S., Woodard, Lauren E.“…BACKGROUND: In diabetic kidney disease, high glucose damages specialized cells called podocytes that filter blood in the glomerulus. …”
Publicado 2022
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202588por Xie, Xiangcheng, Yang, Xiu, Wu, Junxia, Tang, Shengjie, Yang, LiLi, Fei, Xiao, Wang, Ming“…RESULTS: As compared to sham operation mice, IRI mice showed high contents of serum BUN and Scr, and more severe damaged kidney tissues on days 1 and 3, which all gradually declined over time, showing the lowest level on day 7 after injury. …”
Publicado 2022
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202589por Zhao, Xuan, Jiang, Lin, Fang, Xiuyu, Guo, Zhiqiang, Wang, Xiaoxu, Shi, Baoming, Meng, Qingwei“…In diseased Yorkshire pigs, more terms belonging to biological processes of immunity were enriched, including Toll-like receptors signalling, NF-κB signalling and Th1 and Th17-type immune responses, along with the increases of potentially harmful microbes and damaged intestinal barrier. CONCLUSIONS: Cumulatively, the results for the two pig breeds highlight that host-microbiota crosstalk promotes a disease resistance phenotype in three ways: by maintaining partial PRR nonactivation, maintaining Th2-type immune superiority and immunological tolerance patterns and recovering gut barrier function to protect against colonic diseases. …”
Publicado 2022
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202590por Tao, De-Liang, Zhao, Shan-Shan, Chen, Jin-Ming, Chen, Xi, Yang, Xin, Song, Jun-Ke, Liu, Qun, Zhao, Guang-Hui“…The findings suggested a potential role of SIRT1 as a target to develop control strategies against N. caninum infection. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13071-022-05406-4.…”
Publicado 2022
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202591“…Exclusion criteria were: age < 18 years, genetic hypogonadism, pregnancy and previous treatments that have potentially damaging effects on gonads. RESULTS: We evaluated 171 women (mean age ± SD: 31.5 ± 9.0 years) off L-T4 treatment and 79 women on L-T4 treatment (39.7 ± 9.5 years; P < 0.001). …”
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202592por Sheweita, Salah A., El-dafrawi, Yassmin A., El-ghalid, Osama A., Ghoneim, Alaa A., Wahid, Ahmed“…Histopathological investigations showed that tramadol caused substantial vacuolization with the presence of damaged immature spermatozoid in the testes. However, selenium and garlic treatments showed an increase in healthy sperm production with normal mitotic and meiotic divisions. …”
Publicado 2022
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202593por Miyagi, Tomo, Yamazato, Masanobu, Nakamura, Takuto, Tokashiki, Takashi, Namihira, Yukihiro, Kokuba, Kazuhito, Ishihara, Satoshi, Sakima, Hirokuni, Ohya, Yusuke“…Sympathetic and parasympathetic nerves may be concurrently damaged in patients with PD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12883-022-02872-2.…”
Publicado 2022
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202594por Lu, Xu, Ma, Lei, Zhang, CongCong, Yan, HaoKai, Bao, JinYu, Gong, MeiShuang, Wang, WenHui, Li, Sheng, Ma, ShaoYing, Chen, BaiHong“…RESULTS: We found that grapevine plants under salt stress and alkali stress showed leaf chlorosis, a decline in photosynthetic capacity, a decrease in chlorophyll content and Rubisco activity, an imbalance of Na(+) and K(+), and damaged chloroplast ultrastructure. Fv/Fm decreased under salt stress and alkali stress. …”
Publicado 2022
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202595por Lu, Xue, He, Yaowu, Johnston, Rebecca L., Nanayakarra, Devathri, Sankarasubramanian, Sivanandhini, Lopez, J. Alejandro, Friedlander, Michael, Kalimutho, Murugan, Hooper, John D., Raninga, Prahlad V., Khanna, Kum Kum“…CBL0137 also enhanced the efficacy of DNA damaging platinum-based chemotherapy in HGSC patient-derived xenografts. …”
Publicado 2022
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202596por Aoki, Tomoaki, Wong, Vanessa, Endo, Yusuke, Hayashida, Kei, Takegawa, Ryosuke, Okuma, Yu, Shoaib, Muhammad, Miyara, Santiago J., Yin, Tai, Becker, Lance B., Shinozaki, Koichiro“…Hyperoxia following asphyxia CA is more damaging to the brain and lungs but not the heart.…”
Publicado 2023
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202597por Niemann, Tarek, Greiner, Johannes F.W., Kaltschmidt, Christian, Kaltschmidt, Barbara“…Especially in neurodegenerative diseases such as Alzheimers disease (AD), Parkinson’s disease (PD) or ischemic stroke, sex is a key player for disease progression and recovery of damaged tissue. Recently, the glycoprotein hormone erythropoietin (EPO) has been implicated as a regulator of neuronal differentiation and maturation in female rats. …”
Publicado 2023
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202598por Noren Hooten, Nicole, Mode, Nicolle A., Kowalik, Edward, Omoniyi, Victor, Zonderman, Alan B., Ezike, Ngozi, DiNubile, Mark J., Levinson, Susan L., Evans, Michele K.“…A gelsolin isoform is secreted into the plasma as part of the extracellular actin scavenger system which serves a protective role by digesting and removing actin filaments released from damaged cells. Recent data indicate a role for decreased plasma gelsolin (pGSN) levels as a biomarker of inflammatory conditions. …”
Publicado 2023
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202599por Akolkar, Satish V., Shaikh, Mubarak H., Bhalmode, Mininath K., Pawar, Prabhakar U., Sangshetti, Jaiprakash N., Damale, Manoj G., Shingate, Bapurao B.Enlace del recurso
Publicado 2023
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202600por Alhebshi, Suha A, Alsanosi, Safaa M, AlQashqri, Hamsa S, Alhindi, Yosra Z, Bamagous, Ghazi A, Ayoub, Nahla A, Falemban, Alaa HEnlace del recurso
Publicado 2023
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