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202721por Edwards-Faret, Gabriela, González-Pinto, Karina, Cebrián-Silla, Arantxa, Peñailillo, Johany, García-Verdugo, José Manuel, Larraín, Juan“…In non-regenerative stage animals, mostly damaged tissue was observed, without clear closure of the stumps. …”
Publicado 2021
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202722por Chi, Young-In, Stodola, Timothy J., De Assuncao, Thiago M., Levrence, Elise N., Tripathi, Swarnendu, Dsouza, Nikita R., Mathison, Angela J., Basel, Donald G., Volkman, Brian F., Smith, Brian C., Lomberk, Gwen, Zimmermann, Michael T., Urrutia, Raul“…This type of comprehensive structure- and MD-based analyses should help develop improved impact scoring systems to interpret the damaging effects of variants in this protein and other related proteins as well as provide detailed mechanistic insight that is not currently predictable from sequence alone.…”
Publicado 2021
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202723por Tan, Yi-Zhou, Xu, Xin-Yue, Dai, Ji-Min, Yin, Yuan, He, Xiao-Tao, Zhang, Yi-Lin, Zhu, Tian-Xiao, An, Ying, Tian, Bei-Min, Chen, Fa-Ming“…Next, we examined whether MLT could induce cell rejuvenation by restoring the autophagic processes of damaged cells and explored the underlying signaling pathways. …”
Publicado 2021
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202724por Zhou, Zhi-hang, Liang, Si-yuan, Zhao, Tong-chao, Chen, Xu-zhuo, Cao, Xian-kun, Qi, Ming, Huang, Ying-ying, Ju, Wu-tong, Yang, Meng, Zhu, Dong-wang, Pang, Yi-chuan, Zhong, Lai-ping“…In the H-MnO(2)-PEG/TP treatment group, HE staining showed that most of the tumor cells were severely damaged, and TUNEL assay showed cell apoptosis was up-regulated. …”
Publicado 2021
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202725por Wuschner, Antonia E., Wallat, Eric M., Flakus, Mattison J., Shanmuganayagam, Dhanansayan, Meudt, Jennifer, Christensen, Gary E., Reinhardt, Joseph M., Miller, Jessica R., Lawless, Michael J., Baschnagel, Andrew M., Bayouth, John E.“…B-spline deformable image registration allowed for voxel-by-voxel comparative analysis in these contours between timepoints. …”
Publicado 2021
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202726por Monteiro, Ana Carolina Costa, Flori, Heidi, Dahmer, Mary K., Sim, Myung Shin, Quasney, Michael W., Curley, Martha A. Q., Matthay, Michael A., Sapru, Anil“…In healthy lung endothelium, thrombomodulin (TM) recruits thrombin to activate Protein-C (PC/APC), that inhibits plasminogen activator-1 (PAI-1) and thrombosis. In inflamed and damaged endothelium, TM is cleaved into its soluble form (sTM), precluding its usual regulation of thrombosis. …”
Publicado 2021
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202727por Ansari, Mohammad Azam, Akhtar, Sultan, Rauf, Mohd Ahmar, Alomary, Mohammad N, AlYahya, Sami, Alghamdi, Saad, Almessiere, M A, Baykal, Abdulhadi, Khan, Firdos, Adil, Syed Farooq, Khan, Mujeeb, Hatshan, Mohammad Rafe“…Additionally, SEM and TEM examination revealed that NSFs extensively damaged the cell walls and membranes of MRSA and C. albicans. …”
Publicado 2021
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202728“…When HyA of the desired molecular weight is implanted into the human body for regeneration of damaged tissue, it is degraded by hyaluronidase in associated with an inflammatory response. …”
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202729por Yang, Pei-Kui, Liang, Xue-Yan, Lin, Min, Chen, Jiang-Tao, Huang, Hui-Ying, Lin, Li-Yun, Ehapo, Carlos Salas, Eyi, Urbano Monsuy, Zheng, Yu-Zhong, Xie, Dong-De, He, Jin-Quan, Mo, Huan-Tong, Chen, Xin-Yao, Liu, Xiang-Zhi, Wu, Ying-E.“…The mutations A34T, K109E, D278Y, K301N, L305V and D329N were predicted as probably damaging. CONCLUSIONS: This study demonstrated that the dimorphism of F-fragment PfEBA-175 was remarkably predominant in the study area. …”
Publicado 2021
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202730“…Therefore, using physiological substances is promising due to no risk of development, for example, of microbial resistances, allergies or DNA damaging. The lactoperoxidase-thiocyanate-hydrogen peroxide system (LPO-system) is a highly effective antimicrobial system. …”
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202731por Wei, Jinhuan, Su, Wenfeng, Zhao, Yayu, Wei, Zhongya, Hua, Yuchen, Xue, Peng, Zhu, Xiang, Chen, Ying, Chen, Gang“…Immunohistochemistry analyses showed that the administration of MaR1 to mice with nerve crush injury reduced the number of damaged DRG neurons, promoted injured nerve regeneration and inhibited gastrocnemius muscle atrophy. …”
Publicado 2022
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202732por O’Connor, Thomas N., Kallenbach, Jacob G., Orciuoli, Haley M., Paris, Nicole D., Bachman, John F., Johnston, Carl J., Hernady, Eric, Williams, Jacqueline P., Dirksen, Robert T., Chakkalakal, Joe V.“…CONCLUSIONS: Juvenile irradiation stunted muscle development, disrupted proper Ca(2+) handling, damaged mitochondria, and increased oxidative and nitrosative stress, paralleling significant deficits in muscle force production. …”
Publicado 2022
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202733por Tenni, Brigitte, Moir, Hazel V. J., Townsend, Belinda, Kilic, Burcu, Farrell, Anne-Maree, Keegel, Tessa, Gleeson, Deborah“…There were few studies that included resource poor settings, signalling a need for greater research in such settings where the impact on access to medicines is likely to be more damaging. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12992-022-00826-4.…”
Publicado 2022
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202734por Chen, Xihui, Liu, Fangfang, Li, Bowen, Wang, Yufeng, Yuan, Lijuan, Yin, Anan, Chen, Qi, Hu, Weihong, Yao, Yan, Zhang, Mengjie, Wu, YuanMing, Chen, Kun“…CONCLUSIONS: The Fars2 deficiency genetic models developed in this study cover the typical clinical manifestations in FARS2 patients, and help clarify how neuropathy-associated Fars2 deficiency, by damaging the mitochondrial respiratory chain and impairing mitochondrial function, affects neuronal development and potentiates neuronal cell apoptosis. …”
Publicado 2022
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202735por Navarrete, Carmen, García-Martín, Adela, Correa-Sáez, Alejandro, Prados, María E., Fernández, Francisco, Pineda, Rafael, Mazzone, Massimiliano, Álvarez-Benito, Marina, Calzado, Marco A., Muñoz, Eduardo“…In addition, VCE-004.8 attenuates neuroinflammation and reduces neuronal death and apoptosis in the damaged area. CONCLUSIONS: This study provides new insight about the mechanism of action of VCE-004.8 regulating the PP2A/B55α/PHD2/HIF pathway. …”
Publicado 2022
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202736por Coates, Brad S., Walden, Kimberly K. O., Lata, Dimpal, Vellichirammal, Neetha Nanoth, Mitchell, Robert F., Andersson, Martin N., McKay, Rachel, Lorenzen, Marcé D., Grubbs, Nathaniel, Wang, Yu-Hui, Han, Jinlong, Xuan, Jing Li, Willadsen, Peter, Wang, Huichun, French, B. Wade, Bansal, Raman, Sedky, Sammy, Souza, Dariane, Bunn, Dakota, Meinke, Lance J., Miller, Nicholas J., Siegfried, Blair D., Sappington, Thomas W., Robertson, Hugh M.“…Resistance of D. v. virgifera to crop rotation practices and multiple insecticides contributes to its status as the most damaging pest of cultivated maize in North America and Europe. …”
Publicado 2023
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202737por Wang, Shouhong, Shibata, Yuki, Fu, Liezhen, Tanizaki, Yuta, Luu, Nga, Bao, Lingyu, Peng, Zhaoyi, Shi, Yun-Bo“…BACKGROUND: Animal regeneration is the natural process of replacing or restoring damaged or missing cells, tissues, organs, and even entire body to full function. …”
Publicado 2023
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202738por Jayasinghe, Sisitha, Holloway, Timothy P, Soward, Robert, Patterson, Kira A E, Ahuja, Kiran D K, Dalton, Lisa, Murray, Sandra, Hughes, Roger, Byrne, Nuala M, Hills, Andrew P“…The rampant global prevalence of obesity indicates that the customary, reductionistic, and disease-oriented biomedical approach to health service delivery is inadequate/ineffective at arresting the spread and mitigating the damaging consequences of the condition. There is an urgent need to shift the focus from reactive downstream disease-based treatments to more proactive, upstream, preventive action. …”
Publicado 2023
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202739por Dlamini, Zodwa, Khanyile, Richard, Molefi, Thulo, Damane, Botle Precious, Bates, David Owen, Hull, RodneyEnlace del recurso
Publicado 2023
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202740por Nduom, Edjah K., Glod, John, Brown, Desmond A., Fagan, Margaret, Dalmage, Mahalia, Heiss, John, Steinberg, Seth M., Peer, Cody, Figg, William D., Jackson, Sadhana“…Diffuse midline gliomas (DMG) are the most aggressive brain tumors of childhood and young adults, with documented 2-year survival rates <10%. …”
Publicado 2023
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