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202841“…The MPO level in the liver, the IL-6, TNF-α, CRP, IL-12, and MMP-9 levels in the plasma, and the serum ALT and AST levels also decreased, thereby reducing LPS/D-GalN-induced liver injury and improving the survival rate of liver-damaged animals within 24 h. CONCLUSIONS: S. sarmentosum extract can alleviate LPS/D-GalN-induced acute liver injury in mice and improve the survival rate of mice. …”
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202842por Phillips, Richard O, Robert, Jérôme, Abass, Kabiru Mohamed, Thompson, William, Sarfo, Fred Stephen, Wilson, Tuah, Sarpong, Godfred, Gateau, Thierry, Chauty, Annick, Omollo, Raymond, Ochieng Otieno, Michael, Egondi, Thaddaeus W, Ampadu, Edwin O, Agossadou, Didier, Marion, Estelle, Ganlonon, Line, Wansbrough-Jones, Mark, Grosset, Jacques, Macdonald, John M, Treadwell, Terry, Saunderson, Paul, Paintsil, Albert, Lehman, Linda, Frimpong, Michael, Sarpong, Nanaa Francisca, Saizonou, Raoul, Tiendrebeogo, Alexandre, Ohene, Sally-Ann, Stienstra, Ymkje, Asiedu, Kingsley B, van der Werf, Tjip S“…BACKGROUND: Buruli ulcer is a neglected tropical disease caused by Mycobacterium ulcerans infection that damages the skin and subcutis. It is most prevalent in western and central Africa and Australia. …”
Publicado 2020
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202843“…Whole exome sequencing identified a heterozygous mutation in GATA3 (c.1061C>T, p.Pro354Leu), predicted to be damaging. This variant has not been reported in literature or public database to our knowledge. …”
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202844por Jeng, Henry Shiheng, Knoll, Michelle, Del Viso, Florencia, Baker, Darren, Repnikova, Elena, Feldt, Matthew Maximilian“…It is predicted to be deleterious/probably damaging by in silico tools (SIFT, PolyPhen2). Conclusion: To our knowledge, this is the first case demonstrating the presence of a c.571G>A (p.Glu191Lys) variant in the GNA11 gene, in a child with familial hypocalciuric hypercalcemia as well as in his affected mother. …”
Publicado 2020
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202845“…In the last few months, the spread of COVID-19 among humans has caused serious damages around the globe letting many countries economically unstable. …”
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202846por Shupler, Matthew, Hystad, Perry, Birch, Aaron, Miller-Lionberg, Daniel, Jeronimo, Matthew, Arku, Raphael E, Chu, Yen Li, Mushtaha, Maha, Heenan, Laura, Rangarajan, Sumathy, Seron, Pamela, Lanas, Fernando, Cazor, Fairuz, Lopez-Jaramillo, Patricio, Camacho, Paul A, Perez, Maritza, Yeates, Karen, West, Nicola, Ncube, Tatenda, Ncube, Brian, Chifamba, Jephat, Yusuf, Rita, Khan, Afreen, Hu, Bo, Liu, Xiaoyun, Wei, Li, Tse, Lap Ah, Mohan, Deepa, Kumar, Parthiban, Gupta, Rajeev, Mohan, Indu, Jayachitra, K G, Mony, Prem K, Rammohan, Kamala, Nair, Sanjeev, Lakshmi, P V M, Sagar, Vivek, Khawaja, Rehman, Iqbal, Romaina, Kazmi, Khawar, Yusuf, Salim, Brauer, Michael“…Few monitoring studies have systematically measured health-damaging air pollutant (ie, fine particulate matter [PM(2·5)] and black carbon) concentrations from a wide range of cooking fuels across diverse populations. …”
Publicado 2020
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202847por Mboma, Zawadi M., Festo, Charles, Lorenz, Lena M., Massue, Dennis J., Kisinza, William N., Bradley, John, Moore, Jason D., Mandike, Renata, Akim, Ikupa, Lines, Jo, Overgaard, Hans J., Moore, Sarah J.“…This study assessed how nets are allocated within households to individuals of different age categories as ITNs are lost or damaged and as new ITNs are obtained. The study also explored how ITN allocation affects ITN durability. …”
Publicado 2021
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202848“…Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta Diabetol. 2010;47(3):193–199.2. …”
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202849“…Form-Acetic also enabled the detection of damaged DNA via the TUNEL assay using fluorescence. …”
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202850por Roy, Nainita, Sundar, Swetha, Pillai, Malini, Patell-Socha, Farah, Ganesh, Sravya, Aloysius, Ajoy, Rumman, Mohammed, Gala, Hardik, Hughes, Simon M., Zammit, Peter S., Dhawan, Jyotsna“…BACKGROUND: During skeletal muscle regeneration, satellite stem cells use distinct pathways to repair damaged myofibers or to self-renew by returning to quiescence. …”
Publicado 2021
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202851“…PROPOSE: Skeletal muscle regenerative capacity fails in restoring muscle function following major injuries in which significant skeletal muscle is lost or damaged. As such, volumetric muscle loss (VML), ultimately results in permanent disability. …”
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202852por Raghuram, Anjali C., Yu, Roy P., Hsu, Jerry F., Sung, Cynthia, Lo, Andrea Y., Yao, Jingxin, Manoukian, Haig L., Wang, Sarah X., Park, Sun Young, Jiao, Wan, Han, Bo, Wong, Alex K.“…We have previously demonstrated that fibronectin is a key extracellular matrix glycoprotein known to be significantly downregulated in radiation-damaged skin. We further identified that an enzymatically crosslinked hydrogel is a suitable construct for incremental fibronectin release in vitro and in murine wound models. …”
Publicado 2021
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202853por Aswath, Kshama, Welch, James, Gubbi, Sriram, Veeraraghavan, Padmasree, Avadhanula, Shirisha, Gara, Sudheer Kumar, Dikoglu, Esra, Merino, Maria, Raffeld, Mark, Xi, Liqiang, Kebebew, Electron, Klubo-Gwiezdzinska, Joanna“…This variant is predicted to be damaging/pathogenic in 17/20 in-silico models. However, immunostaining performed on the thyroid tumor tissue of two affected by FNMTC family members revealed intact nuclear expression of MSH2, and microsatellite stable status in both tumors that were tested. …”
Publicado 2021
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202854por Kushkevych, Ivan, Bychkov, Mykola, Bychkova, Solomiia, Gajdács, Márió, Merza, Romana, Vítězová, Monika“…Autophagy leads to an accumulation of damaged mitochondria by autophagosomes. An acidic environment is maintained in compartments of cells, such as autophagosomes, late endosomes, and lysosomes; these organelles belong to the “acid store” of the cells. …”
Publicado 2021
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202855
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202856por Shao, Jingjing, Liu, Shibo, Zhang, Min, Chen, Shujiang, Gan, Shuaiqi, Chen, Chenfeng, Chen, Wenchuan, Li, Lei, Zhu, Zhimin“…However, 2-methoxyestradiol improved bone-vessel metabolism of aged mice while damaged that of young mice. Mechanically, HIF1α showed opposed effects in regulating the cell migration and osteogenesis–angiogenesis coupling of YBMSCs and ABMSCs, but no remarked effect on the proliferation of either cell type. …”
Publicado 2022
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202857por Sanooghi, Davood, Lotfi, Abolfazl, Bagher, Zohreh, Barati, Shirin, Karimi, Afzal, Faghihi, Faezeh, Lotfi, Erfan, Joghataei, Mohammad Taghi“…Using stem cells (e.g., human umbilical cord blood mesenchymal stem cells) is currently a potent medical approach for modulating the impact of neural damages and regeneration of spinal cord injuries. …”
Publicado 2022
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202858por Hayes, Anthony J., Farrugia, Brooke L., Biose, Ifechukwude J., Bix, Gregory J., Melrose, James“…Perlecan domain V promotes reconstitution of the blood brain barrier damaged by ischemic stroke and is neurogenic and neuroprotective. …”
Publicado 2022
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202859por Mattia, Giulia Maria, Sarton, Benjamine, Villain, Edouard, Vinour, Helene, Ferre, Fabrice, Buffieres, William, Le Lann, Marie-Veronique, Franceries, Xavier, Peran, Patrice, Silva, Stein“…BACKGROUND: There is an unfulfilled need to find the best way to automatically capture, analyze, organize, and merge structural and functional brain magnetic resonance imaging (MRI) data to ultimately extract relevant signals that can assist the medical decision process at the bedside of patients in postanoxic coma. …”
Publicado 2022
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202860por Barnes, Danielle, Herman, Meredith, Hernandez, Nahimarys, Koltz, Brooke, Sohn, David, Maier, Jacob“…However, the extent to which this energy penetrates the adjacent tissue, potentially damaging nearby vasculature and osteocytes, is unknown. …”
Publicado 2022
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