Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Excess glutamate release in hypoxic-ischemic conditions causes excitotoxic damage to the RGCs through activation of ionotropic and metabotropic glutamate receptors. …”
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here I show that parkin translocates into nucleus upon DNA damage. Nuclear translocation of parkin appears to be required to promote DNA repair. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Therefore, it has long been known that the structural appearance of the optic nerve head is paramount to both glaucoma diagnosis and to the detection of progression [1-4]. Quantitative imaging methods such as Heidelberg Retinal Tomography (HRT) and Ocular Coherence Tomography (OCT) show great promise for the diagnosis and management of glaucoma and as these technologies continue to improve, they will become more important in the care of glaucoma. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Melatonin may also lower the rate of DNA base damage resulting from hydroxyl radical attack and increase the rate of repair of that damage. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Alcohol is a well-known cytotoxic agent which causes various kinds of neuronal damage. In spite of thousands of published studies, the true mechanism of alcohol-induced neuronal damage remains unclear. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Retinal ganglion cell survival following excitotoxic damage was much greater in animals overexpressing UCP2. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso

“…In cells, DNA repair has to keep up with DNA damage to maintain the integrity of the genome and prevent mutagenesis and carcinogenesis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We have used FRET and restriction enzyme accessibility to study nucleosome dynamics following DNA damage by UV radiation. We find that FRET efficiency is reduced in a dose-dependent manner, showing that the presence of UV photoproducts enhances spontaneous unwrapping of DNA from histones. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Genome maintenance is ensured by a variety of biochemical sensors and pathways that repair accumulated damage. During mitosis, the mechanisms that sense and resolve DNA damage remain elusive. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It is generally considered as a cytotoxic drug which kills cancer cells by damaging DNA and inhibiting DNA synthesis. How cells respond to cisplatin-induced DNA damage plays a critical role in deciding cisplatin sensitivity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The observation of highly efficient DNA damage confirmed that lysine acetylene conjugate is capable of cleaving the densely compacted intracellular DNA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…OBJECTIVES: It is unknown if telbivudine causes muscle damage only in patients with pre-existing muscle pathology. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Like EAU, sympathetic ophthalmia also results in photoreceptor mitochondrial oxidative damage. Agents that prevent mitochondrial oxidative stress and photoreceptor apoptosis may help prevent retinal damage and preserve vision in uveitis.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso

“…The models used in this study provide valuable systems for the investigation of therapeutic strategies to prevent axonal or neuronal damage.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this brief paper, we discuss mechanisms involved in the vascular damage of CKD patients, aiming to point out that important factors beyond hypertension are largely responsible for endothelial activation and increased CVD risk, with potential impact on risk stratification and development of novel therapeutic options.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso