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561“…Although benign in healthy muscle, contractions in dystrophic muscle may contribute to a higher degree of muscle damage which eventually overwhelms muscle regeneration capacity. …”
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562
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563“…Products of various forms of DNA damage have been implicated in a variety of important biological processes, such as aging, neurodegenerative diseases, and cancer. …”
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564
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565por Rellick, Stephanie L., O'Leary, Heather, Piktel, Debbie, Walton, Cheryl, Fortney, James E., Akers, Stephen M., Martin, Karen H., Denvir, James, Boskovic, Goran, Primerano, Donald A., Vos, Jeffrey, Bailey, Nathanael, Gencheva, Marieta, Gibson, Laura F.“…Melphalan and VP-16 induced damage of HOB suggests vulnerability of this critical niche to therapeutic agents frequently utilized in pre-transplant regimens and suggests that dose escalated chemotherapy may contribute to post-transplantation hematopoietic deficits by damaging structural components of this supportive niche.…”
Publicado 2012
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566por Peeters, Sara, Kitz, Michael, Preisser, Stefan, Wetterwald, Antoinette, Rothen‑Rutishauser, Barbara, Thalmann, George N., Brandenberger, Christina, Bailey, Arthur, Frenz, Martin“…The dependence of the cell damage threshold on the nanoparticle concentration during incubation reveals that particle accumulation and distribution inside the cell plays a key role in tissue imaging or cell damaging.…”
Publicado 2012
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567por Sepp, Tuul, Karu, Ulvi, Blount, Jonathan D., Sild, Elin, Männiste, Marju, Hõrak, Peeter“…The main tenet of immunoecology is that individual variation in immune responsiveness is caused by the costs of immune responses to the hosts. Oxidative damage resulting from the excessive production of reactive oxygen species during immune response is hypothesized to form one of such costs. …”
Publicado 2012
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568por Van Horn, John Darrell, Irimia, Andrei, Torgerson, Carinna M., Chambers, Micah C., Kikinis, Ron, Toga, Arthur W.“…Using diffusion weighted (DWI) and magnetic resonance imaging (MRI), WM fiber pathways between brain regions may be systematically assessed to make inferences concerning their role in normal brain function, influence on behavior, as well as concerning the consequences of network-level brain damage. …”
Publicado 2012
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569“…CRLs are involved in cell cycle regulation, DNA replication, DNA damage response (DDR), development, immune response, transcriptional regulation, circadian rhythm, viral infection, and protein quality control. …”
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570“…The accrual of oxidative stress and damage has been the predominant mechanistic explanation for the process of aging for many years, but reviewing the recent studies in C. elegans calls this theory into question. …”
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571“…Modulation of circulating L-selectin is a promising target for reducing skin damage in dSSc patients. Plasma levels of soluble L-selectin could serve as an outcome measure for dSSc patients in clinical trials.…”
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572“…Cells are constantly exposed to a variety of environmental and endogenous conditions causing DNA damage, which is detected and repaired by conserved DNA repair pathways to maintain genomic integrity. …”
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573“…Organisms are continuously exposed to DNA damaging agents, consequently, cells have developed an intricate system known as the DNA damage response (DDR) in order to detect and repair DNA lesions. …”
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574“…Recent work has shed light on the mechanisms that link abnormal mitosis with the development of DNA damage, how cells respond to such affronts, and the potential impact on tumorigenesis.…”
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575“…However, with additional oxidative abuse caused by exogenous or endogenous prooxidants (ionizing radiation being the most spectacular), increased damage to macromolecules occurs, potentially leading to different thyroid diseases, cancer included.…”
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576por Tsigou, Evdoxia, Psallida, Vasiliki, Demponeras, Christos, Boutzouka, Eleni, Baltopoulos, George“…Traditional diagnosis of acute kidney injury (AKI) depends on detection of oliguria and rise of serum creatinine level, which is an unreliable and delayed marker of kidney damage. Delayed diagnosis of AKI in the critically ill patient is related to increased morbidity and mortality, prolonged length of stay, and cost escalation. …”
Publicado 2013
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577por Creemers, Daan H. M., Scholte, Ron H. J., Engels, Rutger C. M. E., Prinstein, Mitchell J., Wiers, Reinout W.“…These findings provide further support that specifically damaged self-esteem is an important vulnerability marker for depressive symptoms, suicidal ideation, and loneliness.…”
Publicado 2013
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579“…Cholesterol level, lipid peroxidation, glutathione level (GSH), and antioxidant enzyme activities in erythrocytes were investigated. The damage to erythrocyte proteins was also indicated by means of activity of ATPase (total and Na(+),K(+) ATPase) and thiol group level. …”
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580por Rosen, Eliot M.“…Here, we will review BRCA1 functions in the DNA damage response (DDR), which are likely to contribute to tumor suppression. …”
Publicado 2013
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