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581por Feinstein, Justin S., Buzza, Colin, Hurlemann, Rene, Follmer, Robin L., Dahdaleh, Nader S., Coryell, William H., Welsh, Michael J., Tranel, Daniel, Wemmie, John A.“…Surprisingly, we found that inhalation of 35% CO(2) evoked not only fear, but also panic attacks, in three rare patients with bilateral amygdala damage. These results indicate that the amygdala is not required for fear and panic, and make an important distinction between fear triggered by external threats from the environment versus fear triggered internally by CO(2).…”
Publicado 2013
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582“…The addition and removal of ubiquitin or ubiquitin-like proteins from factors has recently been demonstrated as a key mechanism to modulate DNA damage response (DDR) pathways. It is thus, timely to evaluate the potential for ubiquitin pathway enzymes as DDR drug targets for therapeutic intervention. …”
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583por Tian, Kun, Rajendran, Ramkumar, Doddananjaiah, Manjula, Krstic-Demonacos, Marija, Schwartz, Jean-Marc“…The model contains 206 nodes representing genes or proteins, DNA damage input, apoptosis and cellular senescence outputs, connected by 738 logical interactions. …”
Publicado 2013
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584por Miedema, Frank, Hazenberg, Mette D., Tesselaar, Kiki, van Baarle, Debbie, de Boer, Rob J., Borghans, José A. M.Enlace del recurso
Publicado 2013
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586“…This study has therefore identified a novel regulatory relationship between cellular redox, copper homeostasis, and the DNA damage response in yeast.…”
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587“…Autopsy revealed a saddle-shaped old organized thrombi in the main pulmonary artery, relatively fresh thrombi in both pulmonary arteries, and localized diffuse alveolar damage (DAD) in the bilateral upper lung fields. The hypoperfused regions resulting from the thromboembolism anatomically coincided with the pulmonary lesion where DAD was identified. …”
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588por Diculescu, Victor Constantin, Paquim, Ana-Maria Chiorcea, Brett, Ana Maria Oliveira“…Several types of bioanalytical method use nucleic acids probes to detect DNA damage. This article reviews current directions and strategies in the development and applications of electrochemical DNA sensors for the detection of DNA damage.…”
Publicado 2005
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590por Mirhoseini, Mehri, Saki, Ghasem, Hemadi, Masoud, Khodadadi, Ali, Mohammadi Asl, JavadEnlace del recurso
Publicado 2014
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592por Mohammadzadeh, Mohammad Ali, Mohammadzadeh, Maryam, Mohammadzadeh, Ali, Herfatkar, Rasoul, Mohammadzadeh, Vahid, Baghi, Iraj, Heydari, Hamid, Najafi, Sona, Jalili, Michael“…BACKGROUND: Arterial damage is sometimes associated with supracondylar fractures of the humerus. …”
Publicado 2012
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593por Kai, Mihoko“…DNA damage occurs during DNA replication, spontaneous chemical reactions, and assaults by external or metabolism-derived agents. …”
Publicado 2013
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594“…Our findings indicate a role for Nesprin-1 in the DNA damage response pathway and propose Nesprin-1 as novel player in tumorigenesis and genome instability.…”
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598“…Thus, a consequence of mating for C. elegans hermaphrodites is physical cuticle damage. These experiments did not assess the consequences of cuticle damage for lifespan, and the biological significance of this damage remains unclear. …”
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599por Kohshi, Kiyotaka, Tamaki, Hideki, Lemaître, Frédéric, Okudera, Toshio, Ishitake, Tatsuya, Denoble, Petar J.“…We conducted this study to investigate whether long-term breath-hold divers who may be exposed to repeated symptomatic and asymptomatic brain injuries, show brain damage on magnetic resonance imaging (MRI). SUBJECTS AND METHODS: Our study subjects were 12 commercial breath-hold divers (Ama) with long histories of diving work in a district of Japan. …”
Publicado 2014
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600“…Oxidative stress and mitochondrial damage have been implicated in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. …”
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