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661
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662por Dada, RimaEnlace del recurso
Publicado 2017
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663
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664
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666por Kotelnikova, Ekaterina, Kiani, Narsis A., Abad, Elena, Martinez-Lapiscina, Elena H., Andorra, Magi, Zubizarreta, Irati, Pulido-Valdeolivas, Irene, Pertsovskaya, Inna, Alexopoulos, Leonidas G., Olsson, Tomas, Martin, Roland, Paul, Friedemann, Tegnér, Jesper, Garcia-Ojalvo, Jordi, Villoslada, Pablo“…Multiple Sclerosis (MS) is an autoimmune disease driving inflammatory and degenerative processes that damage the central nervous system (CNS). However, it is not well understood how these events interact and evolve to evoke such a highly dynamic and heterogeneous disease. …”
Publicado 2017
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667“…The protoparvovirus minute virus of mice (MVM) infects murine and transformed human cells provoking a sustained DNA damage response (DDR). This DDR is dependent on signaling by the ATM kinase and leads to a prolonged pre-mitotic cell cycle block that features the inactivation of ATR-kinase mediated signaling, proteasome-targeted degradation of p21, and inhibition of cyclin B1 expression. …”
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669por Obad, Adam, Peeran, Ahmed, Little, Janay I., Haddad, Georges E., Tarzami, Sima T.“…It was found that TNF-α could promote and accelerate local inflammation and damage through autocrine/paracrine mechanisms. Unraveling the mechanisms linking chronic alcohol consumption with proinflammatory cytokine production and subsequent inflammatory signaling pathways activation in the heart and CNS, is essential to improve our understanding of the disease and hopefully facilitate the development of new remedies.…”
Publicado 2018
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670por Rodriguez, Eleazar, Chevalier, Jonathan, El Ghoul, Hassan, Voldum-Clausen, Kristoffer, Mundy, John, Petersen, Morten“…DNA damage observed during plant immune responses is reported to be an intrinsic component of plant immunity. …”
Publicado 2018
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671“…However, apart from genetically well-defined high-confidence and other susceptibility loci, the role of DNA damage and repair strategies of the genome as a whole, either elicited as a direct consequence of the underlying genetic mutation or seen as an autonomous parameter, in the initiation and progression of ALS, and the different cues involved in either process are still incompletely understood. …”
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672“…Growing human head hair contains a history of keratin and provides a unique model for studies of protein damage. Here, we examined mechanism of homocysteine (Hcy) accumulation and keratin damage in human hair. …”
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673“…Oil exposure during the cleaning tasks has caused an increase in the genotoxic damage in individuals, the comet assay being the most sensitive biomarker to detect it. …”
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674“…The mechanism of cell damage by ultrasound in combination with hematoporphyrin was studied. …”
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675por Wakida, Nicole M., Cruz, Gladys Mae S., Ro, Clarissa C., Moncada, Emmanuel G., Khatibzadeh, Nima, Flanagan, Lisa A., Berns, Michael W.“…Laser nanosurgery was used to damage individual cells in both primary mouse cortical astrocytes and an established astrocyte cell line. …”
Publicado 2018
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676“…In response to transcription-blocking DNA lesions such as those generated by UV irradiation, cells activate a multipronged DNA damage response. This response encompasses repair of the lesions that stall RNA polymerase (RNAP) but also a poorly understood, genome-wide shutdown of transcription, even of genes that are not damaged. …”
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677“…Cryptococcus neoformans is not usually considered a cytotoxic fungal pathogen but there is considerable evidence that this microbe can damage host cells and tissues. In this essay, we review the evidence that C. neoformans damages host cells and note that the mechanisms involved are diverse. …”
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678por Jamurtas, Athanasios Z.Enlace del recurso
Publicado 2018
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679“…Host immune responses probably play a dominant role in lung damage, as excessive inflammation and elevated expression of lung matrix-degrading proteases are common during TB. …”
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680por Saccà, Sergio Claudio, Cutolo, Carlo Alberto, Ferrari, Daniele, Corazza, Paolo, Traverso, Carlo Enrico“…Long-term exposure to insults, such as UV light, visible light, ionizing radiation, chemotherapeutics, and environmental toxins, contribute to oxidative damage in ocular tissues and expose the aging eye to considerable risk of pathological consequences of oxidative stress. …”
Publicado 2018
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