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683“…The cellular response to DNA damage is vital for the cell's ability to maintain genomic integrity. …”
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684“…Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). …”
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685por Vavla, Marinela, Arrigoni, Filippo, Nordio, Andrea, De Luca, Alberto, Pizzighello, Silvia, Petacchi, Elisa, Paparella, Gabriella, D'Angelo, Maria Grazia, Brighina, Erika, Russo, Emanuela, Fantin, Marianna, Colombo, Paola, Martinuzzi, Andrea“…Twenty-one early-onset FRDA patients and 18 age-matched healthy controls (HCs) were imaged at 3T. All patients underwent a complete cognitive and clinical assessment with ataxia scales. …”
Publicado 2018
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686“…Platelets are classically known for their roles in bleeding control and occlusive thrombus formation causing ischemic tissue damage. Recently, nonclassical roles for platelets have been described, many of which may be mediated by the heterogeneous cargo that platelets secrete from granular stores upon activation. …”
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687por Rahman, Md Habibur, Xiao, Qinru, Zhao, Shirui, Qu, Fuyang, Chang, Chen, Wei, An-Chi, Ho, Yi-Ping“…Characterized by its capability of rapidly processing a limited quantity of samples (200 μL), demarcating the membrane damage through the proposed microscale cell shredder represents a novel strategy to extract subcellular organelles from clinical samples.…”
Publicado 2018
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688“…However, recent research points to a crucial function of cohesin in the DNA damage response (DDR). In this review, we summarize recent advances in the understanding of cohesin function in DNA damage signaling and repair. …”
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689por Lowe, Tristan, Avcu, Egemen, Bousser, Etienne, Sellers, William, Withers, Philip J.“…It is important to be able to visualise the interactions between the bone microstructure and the damage events in three dimensions (3D) to better understand the nature of the damage processes that occur in bone and the relevance of indentation tests in evaluating bone resilience and strength. …”
Publicado 2018
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690por Vítor, Alexandra C., Sridhara, Sreerama C., Sabino, João C., Afonso, Ana I., Grosso, Ana R., Martin, Robert M., de Almeida, Sérgio F.“…Our data provide a novel framework for interpreting the reciprocal interactions between transcription and DNA damage at distinct chromatin regions.…”
Publicado 2019
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691por García-Rodríguez, Anaís, Gosálvez, Jaime, Agarwal, Ashok, Roy, Rosa, Johnston, Stephen“…The aim of this review is to highlight gamete genome organization, differences in the chronology of gamete production between the male and female, the inherent DNA protective mechanisms in these reproductive cells, the aetiology of DNA damage in germ cells, and the remarkable DNA repair mechanisms, pre- and post-syngamy, that function to maintain genome integrity.…”
Publicado 2018
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692“…Ageing is considered as a snowballing phenotype of the accumulation of damaged dysfunctional or toxic proteins and silent mutations (polymorphisms) that sensitize relevant proteins to oxidative damage as inborn predispositions to age-related diseases. …”
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693por Rogers, Susanne J., Puric, Emsad, Eberle, Brigitte, Datta, Niloy R., Bodis, Stephan B.Enlace del recurso
Publicado 2019
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694“…To study and reveal the radiation damage of the silicon drift detector (SDD) in a deep-space environment, which will degrade the detector performance, in this paper, the SDD radiation damage effects and mechanics, including displacement damage and ionization damage, for irradiations of different energy of neutrons and gammas are investigated using Geant4 simulation. …”
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695“…After gastric mucosa damage, the level of H(2)S in the stomach decreases. …”
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696“…Reactive oxygen species (ROS) are small, highly reactive, oxygen-containing molecules that are naturally generated in small amounts during the body’s metabolic reactions and can react with and damage complex cellular molecules such as fats, proteins, or DNA. …”
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697“…This review article provides a concise overview of electron involvement in DNA radiation damage. The review begins with the various states of radiation-produced electrons: Secondary electrons (SE), low energy electrons (LEE), electrons at near zero kinetic energy in water (quasi-free electrons, (e(−)(qf))) electrons in the process of solvation in water (presolvated electrons, e(−)(pre)), and fully solvated electrons (e(−)(aq)). …”
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698“…The genome of cells is constantly challenged by DNA damages from endogenous metabolism and environmental agents. …”
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699por Denzinger, Maximilian, Staendker, Ludger, Ehlers, Keno, Schneider, Julian M., Schulz, Tanja, Hein, Tabea, Wiese, Sebastian, Roecker, Annika, Gross, Ruediger, Münch, Jan, Bracht, Hendrik, Barth, Eberhard, Weiss, Manfred, Georgieff, Michael, Schneider, E. Marion“…Video-based, long-term imaging of mEC proliferation and cell death were evaluated and combined with apoptosis and ATP measurements. …”
Publicado 2019
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