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921por Sánchez-Chapul, Laura, Santamaría, Abel, Aschner, Michael, Ke, Tao, Tinkov, Alexey A., Túnez, Isaac, Osorio-Rico, Laura, Galván-Arzate, Sonia, Rangel-López, Edgar“…Recent focus on Tl toxicity has been devoted to the characterization of its effects at the nuclear level, with emphasis on DNA, which, in turn, may be responsible for cytogenetic damage, mutations, and epigenetic changes. In this work, we review and discuss past and recent evidence on the toxic effects of Tl at the systemic level and its effects on DNA. …”
Publicado 2023
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922por Liu, Pei-Long, Diao, Jia-Yu, Wang, Qiong, Liu, Huan, Zhang, Yan, Liang, Jing-Qi, Zhang, Feng, Liang, Xiao-Jun, Zhao, Hong-Mou“…We herein aimed to investigate the pathological features and pathogenesis of the cartilages damage in DNOAP patients. METHODS: The articular cartilages of eight patients with DNOAP and eight normal controls were included. …”
Publicado 2023
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923por McSwain, Leon F., Pillsbury, Claire E., Haji-Seyed-Javadi, Ramona, Rath, Sandip Kumar, Chen, Victor, Huang, Tiffany, Shahab, Shubin W., Kunhiraman, Haritha, Ross, James, Price, Gabrielle A., Dey, Abhinav, Hambardzumyan, Dolores, MacDonald, Tobey, Yu, David S., Porter, Christopher C., Kenney, Anna M.“…While others have demonstrated a link between YB1 and homologous recombination protein binding, functional and therapeutic implications remain unclear, particularly following IR-induced damage. Here we show that depleting YB1 in both SHH and Group 3 MB results not only in reduced proliferation but also synergizes with radiation due to differential response dynamics. …”
Publicado 2023
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924por Nischwitz, Emily, Schoonenberg, Vivien A.C., Fradera-Sola, Albert, Dejung, Mario, Vydzhak, Olga, Levin, Michal, Luke, Brian, Butter, Falk, Scheibe, Marion“…Genome maintenance is orchestrated by a highly regulated DNA damage response with specific DNA repair pathways. …”
Publicado 2023
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925por Wirestam, Lina, Nyberg, Pernilla Benjaminsson, Dzhendov, Todor, Gasslander, Thomas, Sandström, Per, Sjöwall, Christopher, Björnsson, BergthorEnlace del recurso
Publicado 2023
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926
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927por Song, Haoyun, Shen, Rong, Liu, Xiangwen, Yang, Xuguang, Xie, Kun, Guo, Zhao, Wang, Degui“…DNA is highly vulnerable to spontaneous and environmental timely damage in living cells. DNA damage may cause genetic instability and increase cancer risk if the damages are not repaired timely and efficiently. …”
Publicado 2022
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928“…ADP-ribosylation is a post-translational modification involved in DNA damage response (DDR). In higher organisms it is synthesised by PARP 1–3, DNA strand break sensors. …”
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929por Koenig, Susanna Friederike, Montesano, Giovanni, Fang, Clarissa Ern Hui, Crabb, David Paul, Jayaram, Hari, Clarke, Jonathan“…OBJECTIVES: This study quantifies the effect of trabeculectomy on the rate of progression (RoP) of visual field (VF) damage utilising pre- and post-operative visual function as the outcome instead of surrogate outcomes of success. …”
Publicado 2022
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930“…Damage is the main form of conflict, and the characterization of damage information is an important component of conflict evaluation. …”
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931por Best, Merci N., Lim, Yunu, Ferenc, Nina N., Kim, Nayoung, Min, Lia, Wang, Dora Bigler, Sharifi, Kamyar, Wasserman, Anna E., McTavish, Sloane A., Siller, Karsten H., Jones, Marieke K., Jenkins, Paul M., Mandell, James W., Bloom, George S.“…CONCLUSION: xcTauOs cause partial AIS damage in cultured neurons by a mechanism dependent on intracellular tau, thereby raising the possibility that the observed AIS reduction in AD neurons in vivo is caused by xcTauOs working in concert with endogenous neuronal tau.…”
Publicado 2023
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932“…Hence, this study aimed to investigate the causal effect of kidney damage on fertility and pregnancy using Mendelian randomization (MR). …”
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933por Cunha, Gabriel Moreno, Corso, Gilberto, Lima, Marcelo M. S., dos Santos Lima, Gustavo Zampier“…To further investigate these phenomena, we proposed a damaged model based on the impairment of both the resistance of the ion channels and the capacitance of the lipid membrane. …”
Publicado 2023
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934por Gramatiuk, Svetlana Mykolaiivna, Ivanova, Yulia Viktorovna, Hudyma, Arsen Arsenievich, Sargsyan, Karine, Kryvoruchko, Igor Andreevich, Puliaieva, Inna SergeevnaEnlace del recurso
Publicado 2023
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935
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936por Hutto, Rachel A., Rutter, Kaitlyn M., Giarmarco, Michelle M., Parker, Edward D., Chambers, Zachary S., Brockerhoff, Susan E.“…Intercellular transfer of damaged mitochondria is a recently identified strategy broadly used to improve cellular health and viability. …”
Publicado 2023
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937por Ciplak, Baris, Turmus, Eyup Gokhan, Kara, Ozlem, Daglioglu, Gulcin, Altindag, Mehmet Murat, Simsek, Yavuz, Daglioglu, Yusuf Kenan, Kara, Mustafa“…OBJECTIVE: The objective of this study was to investigate the protectiveness of resveratrol on cisplatin-induced damage to the ovary using experimental models. METHODS: A total of 30 female Wistar-Albino rats constituted the research material. …”
Publicado 2023
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938por Ramamoorthy, Rajalakshmi, Hussain, Hussain, Ravelo, Natalia, Sriramajayam, Kannappan, Di Gregorio, Dibe M., Paulrasu, Kodisundaram, Chen, Pingping, Young, Karen, Masciarella, Andrew D., Jayakumar, Arumugam R., Paidas, Michael J.“…We examined markers in the kidneys related to inflammation, scarring, and damage. We identified that certain markers linked to scarring and inflammation remained high in the mice’s kidneys even after the initial infection, suggesting kidney damage. …”
Publicado 2023
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939
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940“…BACKGROUND: The thalamic gray-white matter ratios (GWRs) on CT and quantitative suppression ratios (SRs) of background activities on EEG may reflect damages in the thalamus and cerebral hemispheres in patients with hypoxic-ischemic encephalopathy (HIE). …”
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