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1141por Kai, Mihoko“…Cells have evolved elaborate mechanisms to deal with DNA damage. Networks of DNA damage response (DDR) pathways are coordinated to detect and repair DNA damage, regulate cell cycle and transcription, and determine the cell fate. …”
Publicado 2016
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1142“…We report that in primary mouse embryonic fibroblasts (MEFs), DNA damage quickly led to Ect2 relocalization to the chromatin and DNA damage foci-like structures. …”
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1143por Montenegro, M F, González-Guerrero, R, Sánchez-del-Campo, L, Piñero-Madrona, A, Cabezas-Herrera, J, Rodríguez-López, J N“…Because the epigenetic factors involved in the DNA damage response are regulated by multiple elements, therapies to target specific components of the epigenetic machinery can be inefficient. …”
Publicado 2016
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1144por Porro, AntonioEnlace del recurso
Publicado 2016
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1145“…Mammalian cells evolve a delicate system, the DNA damage response (DDR) pathway, to monitor genomic integrity and to prevent the damage from both endogenous end exogenous insults. …”
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1146por Bautista-Niño, Paula K., Portilla-Fernandez, Eliana, Vaughan, Douglas E., Danser, A. H. Jan, Roks, Anton J. M.“…In recent years evidence has accumulated that unrepaired DNA damage may play an important role. Observations in animal models and in humans indicate that under conditions during which DNA damage accumulates in an accelerated rate, functional decline of the vasculature takes place in a similar but more rapid or more exaggerated way than occurs in the absence of such conditions. …”
Publicado 2016
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1147por Boeing, Stefan, Williamson, Laura, Encheva, Vesela, Gori, Ilaria, Saunders, Rebecca E., Instrell, Rachael, Aygün, Ozan, Rodriguez-Martinez, Marta, Weems, Juston C., Kelly, Gavin P., Conaway, Joan W., Conaway, Ronald C., Stewart, Aengus, Howell, Michael, Snijders, Ambrosius P., Svejstrup, Jesper Q.“…In order to facilitate the identification of factors and pathways in the cellular response to UV-induced DNA damage, several descriptive proteomic screens and a functional genomics screen were performed in parallel. …”
Publicado 2016
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1149“…DNA is subject to a wide variety of damage. In order to maintain genomic integrity, cells must respond to this damage by activating repair and cell cycle checkpoint pathways. …”
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1151“…This is collectively known as the DNA damage response (DDR), and genome stability mechanisms involve a complex network of signalling and processing factors that ensure redundancy and adaptability of these systems. …”
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1153por Stojkovič, Gorazd, Makarova, Alena V., Wanrooij, Paulina H., Forslund, Josefin, Burgers, Peter M., Wanrooij, Sjoerd“…Oxidative stress is capable of causing damage to various cellular constituents, including DNA. …”
Publicado 2016
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1154“…Transcriptional changes and epigenetic modulations have been implicated as the key regulators in HSC ageing process. The DNA damage response (DDR) in the cells involves an orchestrated signaling pathway, consisting of cell cycle regulation, cell death and senescence, transcriptional regulation, as well as chromatin remodeling. …”
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1155“…The cellular response to DNA damage is no exception to the rule. In this review article we focus on DNA damage responses in G2 and Mitosis. …”
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1156por Papadopoulos, Dimitrios V., Koulouvaris, Panagiotis, Lykissas, Marios G., Giannoulis, Dionysios, Georgios, Aggelidakis, Mavrodontidis, Alexandros“…Postoperative clinical examination and ultrasound imaging confirmed the successful restoration of the blood flow. …”
Publicado 2015
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1157“…DNA damage plays a causal role in numerous human pathologies including cancer, premature aging, and chronic inflammatory conditions. …”
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1158por Stefansdottir, Agnes, Johnston, Zoe C., Powles-Glover, Nicola, Anderson, Richard A., Adams, Ian R., Spears, Norah“…When fetal ovaries were treated prior to follicle formation, etoposide resulted in dose-dependent damage, with 150 ng ml(−1) inducing a near-complete absence of healthy follicles. …”
Publicado 2016
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1159por Vattimo, Maria de Fátima Fernandes, Watanabe, Mirian, da Fonseca, Cassiane Dezoti, Neiva, Luciana Barros de Moura, Pessoa, Edson Andrade, Borges, Fernanda Teixeira“…Polymyxin B administration in rats reduced creatinine clearance and increased renal vascular resistance and oxidative damage. Mitochondrial damage was confirmed by electron microscopy and cytosolic localization of cytochrome c. …”
Publicado 2016
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1160por Komatsu, Kenshi“…DNA damage response is finely tuned, with several pathways including those for DNA repair, chromatin remodeling and cell cycle checkpoint, although most studies to date have focused on single pathways. …”
Publicado 2016
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