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1481por De Alba-Alvarado, Mariana Citlalli, Torres-Gutiérrez, Elia, Reynoso-Ducoing, Olivia Alicia, Zenteno-Galindo, Edgar, Cabrera-Bravo, Margarita, Guevara-Gómez, Yolanda, Salazar-Schettino, Paz María, Rivera-Fernández, Norma, Bucio-Torres, Martha Irene“…In Chagas disease, the mechanisms involved in cardiac damage are an active field of study. The factors underlying the evolution of lesions following infection by Trypanosoma cruzi and, in some cases, the persistence of its antigens and the host response, with the ensuing development of clinically observable cardiac damage, are analyzed in this review.…”
Publicado 2023
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1482“…In addition, vascular remodeling may also lead to target-organ damage by interfering with the blood supply to major body organs such as the heart, brain, and kidney. …”
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1483“…Recently, an increasing number of studies have focused on white matter (WM). Magnetic resonance imaging and pathology studies have shown different degrees of WM abnormality during the progression of AD. …”
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1484“…INTRODUCTION: Vesicoureteric reflux (VUR), recurrent urinary tract infection (RUTI), febrile urinary tract infection (FUTI), renal scarring, and renal damage are intimately related. Key factors of renal damage in VUR are suspected to be RUTI and FUTI. …”
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1485“…PURPOSE: To describe chronic rectal mucosal damage after pelvic radiotherapy (RT) for cervical cancer and correlate these findings with clinical symptoms and radiation dose. …”
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1486por Salzano, Marcella, Vázquez-Cedeira, Marta, Sanz-García, Marta, Valbuena, Alberto, Blanco, Sandra, Fernández, Isabel F., Lazo, Pedro A.“…Next, to identify a mechanism that can link VRK1 to poorer prognosis, VRK1 was knocked-down in two breast cancer cell lines that were treated with ionizing radiation or doxorubicin, both inducing DNA damage. Loss of VRK1 resulted in reduced formation of DNA-damage repair foci complexes assembled on the 53BP1 scaffold protein, and this effect was independent of damaging agent or cell type. …”
Publicado 2014
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1487por Roberts, Derek J, Zygun, David A, Kirkpatrick, Andrew W, Ball, Chad G, Faris, Peter D, Bobrovitz, Niklas, Robertson, Helen Lee, Stelfox, H Thomas“…INTRODUCTION: Initial abbreviated surgery with planned reoperation (damage control surgery) is frequently used for major trauma patients to rapidly control haemorrhage while limiting surgical stress. …”
Publicado 2014
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1488“…In this study, we found that polymyxin E can kill its producer P. polymyxa, a Gram-positive bacterium, by disrupting its cell membrane. Membrane damage was clearly revealed by detecting the leakage of intracellular molecules. …”
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1489por Moggia, Claudia, Graell, Jordi, Lara, Isabel, González, Guillermina, Lobos, Gustavo A.“…Fresh blueberries are very susceptible to mechanical damage, which limits postharvest life and firmness. …”
Publicado 2017
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1490por Carter, Rachel J., Nickson, Catherine M., Thompson, James M., Kacperek, Andrzej, Hill, Mark A., Parsons, Jason L.“…PURPOSE: To investigate the precise mechanism of recognition and processing of ionizing radiation (IR)-induced complex DNA damage (CDD), where two or more DNA lesions are in close proximity, in cellular DNA which is packaged with histones to form chromatin. …”
Publicado 2018
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1491por Lin, Xiaoting, Chen, Dongshao, Zhang, Cheng, Zhang, Xiaotian, Li, Zhongwu, Dong, Bin, Gao, Jing, Shen, Lin“…Given the DNA damage checkpoint as a primary target of WEE1 inhibition, our data also demonstrate that AZD1775 abrogated olaparib-activated DNA damage checkpoint through CDC2 de-phosphorylation, followed by mitotic progression with unrepaired DNA damage (marked by increased pHH3-stained and γH2AX-stained cells, respectively). …”
Publicado 2018
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1492por Hsieh, Feng-Chi, Hung, Chun-Tzu, Cheng, Kai-Chun, Wu, Chang-Yi, Chen, Yen-Chun, Wu, Yu-Jen, Liu, Wangta, Chiu, Chien-Chih“…L. barbarum extracts also reduced the activation of γH2AX, a sensor of DNA damage in ARPE-19 cells in a dose-responsive manner. …”
Publicado 2018
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1493por Martin-Rincon, Marcos, Gelabert-Rebato, Miriam, Galvan-Alvarez, Victor, Gallego-Selles, Angel, Martinez-Canton, Miriam, Lopez-Rios, Laura, Wiebe, Julia C., Martin-Rodriguez, Saul, Arteaga-Ortiz, Rafael, Dorado, Cecilia, Perez-Regalado, Sergio, Santana, Alfredo, Morales-Alamo, David, Calbet, Jose A L“…Prolonged or unusual exercise may cause exercise-induced muscle damage (EIMD). To test whether Zynamite(®), a mango leaf extract rich in the natural polyphenol mangiferin, administered in combination with quercetin facilitates recovery after EIMD, 24 women and 33 men were randomly assigned to two treatment groups matched by sex and 5 km running performance, and ran a 10 km race followed by 100 drop jumps to elicit EIMD. …”
Publicado 2020
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1494por Li, Donna, Lopez, Andrew, Sandoval, Carina, Nichols Doyle, Randilea, Fregoso, Oliver I.“…The DNA damage response (DDR) is a signaling cascade that is vital to ensuring the fidelity of the host genome in the presence of genotoxic stress. …”
Publicado 2020
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1495por Fang, Hui, Zhang, Lu, Schickhardt, Sonja, Merz, Patrick R., Yan, Weijia, Leroux, Mélanie, Auffarth, Gerd U.“…During intraocular lens (IOL) implantation it is not uncommon for the injector’s nozzle-tip to get damaged. However, the damage has not been systematically described or evaluated using an objective scale. …”
Publicado 2022
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1496por Broggini, M., Hartley, J. A., Mattes, W. B., Ponti, M., Kohn, K. W., D'Incalci, M.“…The DNA damage and the sequence specificity of guanine-N7 alkylation produced by the novel, positively charged, antineoplastic agent 1,4-bis(2'-chloroethyl)-1,4-diazabicyclo-[2.2.1] heptane dimaleate (Dabis maleate) and its uncharged tertiary amine analogue 1,4-bis(2'-chloroethyl)-1,4-diazacyclohexane (Dabis analogue) were investigated in L1210 cells and isolated DNA. …”
Publicado 1990
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1497por Lin, Jing, Zeng, Jing, Liu, Sha, Shen, Xin, Jiang, Nan, Wu, Yue-Song, Li, Hong, Wang, Long, Wu, Jian-Ming“…Finally, molecular docking simulation, molecular dynamics simulation and western blot analysis were used to explore the relationship between DAMG with its targets. RESULTS: DMAG significantly promoted megakaryocyte differentiation of HEL cells. …”
Publicado 2021
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1498“…The crack defect problem of Ti6AL4V alloy in the hot-forming process cannot be ignored, so we must develop a precise hot-forming damage prediction model. In this study, three high-temperature damage models of Ti6Al4V alloy were developed, considering the temperature and strain rate. …”
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1499“…One method for determining an optimized loading protocol uses membrane characteristics and models of damage, namely osmomechanical damage, temperature damage (e.g., chill injury) and cytotoxicity. …”
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1500“…The oxidative stress response is a cellular defense mechanism that protects cells from oxidative damage and cancer development. The exact molecular mechanism by which reactive oxygen species (ROS) contribute to DNA damage and increase genome instability in prostate cancer merits further investigation. …”
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