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  1. 161
    por Mon, Yusuke, Tamaki, Chisato
    Publicado 2020
    Materias: “…Images in Clinical Medicine…”
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    Pulmonary damage caused by lamotrigine
  2. 162
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    Radiation Damage in Biomolecules and Cells
  3. 163
    “…Pathological features of these two disorders are synaptic loss, neuronal cell death and increased DNA damage. A key pathological protein for the onset and progression of the conditions is the protein tau, a microtubule-binding protein highly expressed in neurons and encoded by the MAPT (microtubule-associated protein tau) gene. …”
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    Tau and DNA Damage in Neurodegeneration
  4. 164
    “…Compared with nuclear DNA, the mitochondrial DNA (mtDNA) is more prone to be affected by DNA damaging agents, and accumulated DNA damages may cause mitochondrial dysfunction and drive the pathogenesis of a variety of human diseases, including neurodegenerative disorders and cancer. …”
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    The Mitochondrial Response to DNA Damage
  5. 165
    “…In Orthopedics, damage control is indicated in patients with pelvic and/or long bone fractures associated with hemodynamic instability. …”
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    Damage control in orthopaedical and traumatology
  6. 166
    por Park, Gunhyuk
    Publicado 2022
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    Oxidative Damage in Korean Medicine
  7. 167
    “…Here we discuss the molecular underpinnings of genomic instability in MB and potential avenues for exploitation through DNA damage response inhibition.…”
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    Medulloblastoma and the DNA Damage Response
  8. 168
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    Epigenetics, DNA damage, and aging
  9. 169
    “…Macroalgae provide food and habitat to a diversity of organisms in marine systems, so structural damage and breakage of thallus tissue can have important ecological consequences for the composition and dynamics of marine communities. …”
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    Ecological biomechanics of damage to macroalgae
  10. 170
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    Viscoelastic damage evaluation of the axon
  11. 171
    “…Rock masses formed after long geological processes generally have some initial damage. Mining works also cause varying degrees of disturbance and damage to rock masses in the mining area during the mining process. …”
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    A new shear creep damage model for rock masses after considering initial damage
  12. 172
    “…During the bridge opening events, the data was recorded continuously with a sampling rate of 200 Hz. The evidence of damage in a real case scenario makes the dataset valuable for testing and evaluation of data-driven routines for infrastructure surveillance.…”
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    Dataset for damage detection retrieved from a monitored bridge pre and post verified damage
  13. 173
    “…We report the case of a worker with a respiratory illness related to bioaerosol exposure in a water-damaged building with extensive fungal contamination. …”
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    Bioaerosol lung damage in a worker with repeated exposure to fungi in a water-damaged building.
  14. 174
    “…These reagents have been used to profile the response to UV damage of DNA in human cell lines. UV damage was shown to activate canonical DNA damage response pathways through ATM/ATR-dependent signaling, stress response pathways and induce the initiation of apoptosis, as assessed by an increase in the abundance of peptides corresponding to cleaved, activated caspases. …”
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    Quantitative Profiling of DNA Damage and Apoptotic Pathways in UV Damaged Cells Using PTMScan Direct
  15. 175
    “…Assuming that damage events depend only on sequencing position and post-mortem deamination, our Bayesian statistical framework provides estimates of four key features of aDNA molecules: the average length of overhangs (λ), nick frequency (ν) and cytosine deamination rates in both double-stranded regions ([Image: see text]) and overhangs ([Image: see text]). …”
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    mapDamage2.0: fast approximate Bayesian estimates of ancient DNA damage parameters
  16. 176
    “…Although the NTR is generally considered the key DNA-binding domain of PARP-2, we report here that all three domains of PARP-2 collectively contribute to interaction with DNA damage. Biophysical, structural and biochemical analyses indicate that the NTR is natively disordered, and is only required for activation on specific types of DNA damage. …”
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    PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damage
  17. 177
    “…The DNA damage response (DDR) is a set of cellular events that follows the generation of DNA damage. …”
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    DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs
  18. 178
    “…Collagen damage in articular cartilage is considered nearly irreversible and may be an early indication of cartilage degeneration. …”
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    Collagen Damage Location in Articular Cartilage Differs if Damage is Caused by Excessive Loading Magnitude or Rate
  19. 179
    “…DNA damage response (DDR) coordinates lesion repair and checkpoint activation. …”
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    Etoposide-induced DNA damage affects multiple cellular pathways in addition to DNA damage response
  20. 180
    “…A novel class of small non-coding RNAs called DNA damage response RNAs (DDRNAs) generated at DNA double-strand breaks (DSBs) in a DROSHA- and DICER-dependent manner has been shown to regulate the DNA damage response (DDR). …”
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    Pharmacological boost of DNA damage response and repair by enhanced biogenesis of DNA damage response RNAs
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