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21por Sutton, Jesse D, Chang, Nai-Chung N, Stevens, Vanessa W, Timbrook, Tristan T, Spivak, Emily S“…The adjusted relative risk (aRR) of the composite primary outcome with LOW was 1.28 (95% CI 0.86–1.89; risk difference [RD] 0.9%). Recurrent EB within 30-days occurred in 14 (1.5%) LOW and 12 (0.4%) HIGH (aRR 3.24, 95% CI, 0.46–22.8; RD 1.0%). …”
Publicado 2019
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22por Kohring, Jessica M., Houck, Jeffrey R., Oh, Irvin, Flemister, Adolf S., Ketz, John P., Baumhauer, Judith F.“…The change in utility T-scores for both PF (0.06, 95% CI 0.02 to 0.11) and PI (0.15, 95% CI 0.09 to 0.20) was significantly improved, however, only PI approached clinical significance. …”
Publicado 2020
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23por Chong, Michael, Mohammadi-Shemirani, Pedrum, Perrot, Nicolas, Nelson, Walter, Morton, Robert, Narula, Sukrit, Lali, Ricky, Khan, Irfan, Khan, Mohammad, Judge, Conor, Machipisa, Tafadzwa, Cawte, Nathan, O'Donnell, Martin, Pigeyre, Marie, Akhabir, Loubna, Paré, Guillaume“…RESULTS: Overall, genetic analyses identified 71 loci for mtDNA-CN, which implicated several genes involved in rare mtDNA depletion disorders, deoxynucleoside triphosphate (dNTP) metabolism, and the MT central dogma. Rare variant analysis identified SAMHD1 mutation carriers as having higher mtDNA-CN (beta = 0.23 SDs; 95% CI, 0.18–0.29; p=2.6 × 10(-19)), a potential therapeutic target for patients with mtDNA depletion disorders, but at increased risk of breast cancer (OR = 1.91; 95% CI, 1.52–2.40; p=2.7 × 10(-8)). …”
Publicado 2022
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24por Schiewe, Mitchel C., Zozula, Shane, Nugent, Nancy, Waggoner, Kelley, Borba, Jessica, Gamboa, Lisa, Whitney, John B.“…The added technical step to the µS-VTF procedure has not affected its successful application, as high survival rates (> 95%) and pregnancy rates continue today.…”
Publicado 2017
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25por Schober, Patrick, Kistemaker, Kay R. J., Sijani, Fereshte, Schwarte, Lothar A., van Groeningen, Dick, Krage, Ralf“…RESULTS: There was no significant difference between the groups for the performance score (mean difference: -0.35, 95%CI: -2.46 to 1.77, P = 0.748, n = 48). The confidence limits excluding the specified relevant 3-point difference suggest equivalence of both techniques with respect to the primary outcome. …”
Publicado 2019
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26“…BACKGROUND: Current dogma contends that prolonged treatment of a dislocated hip in Pavlik harness beyond 3 weeks will cause “Pavlik harness disease.” …”
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27“…BACKGROUND: Current dogma suggests optimizing AG doses based on peak concentration (C(max)), without consideration of daily drug exposure (AUC(24)). …”
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