Mostrando 221 - 240 Resultados de 277 Para Buscar 'Dub K', tiempo de consulta: 0.68s Limitar resultados
  1. 221
    “…A minimal model system for membrane fusion, comprising two complementary peptides dubbed “E” and “K” joined to a cholesterol anchor via a polyethyleneglycol spacer, has previously been developed in our group. …”
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    Peptide-Mediated Liposome Fusion: The Effect of Anchor Positioning
  2. 222
    “…The present study is novel in three main aspects. (1) It is the first study to investigate associations between the PON1 genotype and enzyme kinetics in a large number of subjects. (2) It is the first study to report kinetic parameters of PON1 in a large number of subjects and to use time-concentration progress curves instead of initial velocities to determine K(m) and V(max) in a clinical context. (3) It is also the first study to calculate enzyme-kinetic parameters in a clinical context with a new algorithm for data point removal from progress curves, dubbed iFIT. …”
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    Investigation of Paraoxonase-1 Genotype and Enzyme-Kinetic Parameters in the Context of Cognitive Impairment in Parkinson’s Disease
  3. 223
    “…Experimental results using real datasets from Shanghai Telecom show that DQN-ESPA outperforms state-of-the-art algorithms such as simulated annealing placement algorithm (SAPA), Top-K placement algorithm (TKPA), K-Means placement algorithm (KMPA), and random placement algorithm (RPA). …”
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    An Edge Server Placement Method Based on Reinforcement Learning
  4. 224
    “…Based on these findings, we summarize the close relationship between several DUBs and the precise modulation of mitophagy. For example, the USP8, USP10, and USP15, among many DUBs are reported to specifically regulate the K48- or K63-linked de-ubiquitination reactions of several target proteins associated with the mitophagic process, in turn upregulating the mitophagy and protecting neuronal cells from α-synuclein-derived toxicity. …”
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    Precise control of mitophagy through ubiquitin proteasome system and deubiquitin proteases and their dysfunction in Parkinson’s disease
  5. 225
    “…To fill the gap, we present P3M-10k, which is the first large-scale anonymized benchmark for Privacy-Preserving Portrait Matting (P3M). …”
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    Rethinking Portrait Matting with Privacy Preserving
  6. 226
    “…However, the role of deubiquitinating enzymes (DUBs) in bone resorption is still not well defined. …”
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    The deubiquitinase UCHL1 negatively controls osteoclastogenesis by regulating TAZ/NFATC1 signalling
  7. 227
    “…However, the loop-less triple mutant (tm) Cdc34, which not only lacks the loop but also contains the S73K and S97D substitutions typical of the K73/D97/no loop motif present in other E2s, supports growth. …”
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    The loop-less (tm)Cdc34 E2 mutant defective in polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2
  8. 228
    “…This process is reversible by the action of deubiquinating enzymes (DUBs). USP45 is a ubiquitin specific protease about which little is known, aside from roles in DNA damage repair and differentiation of the vertebrate retina. …”
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    USP45 and Spindly are part of the same complex implicated in cell migration
  9. 229
    “…We report on a study of heat flow in bulk black phosphorus between 0.1 and 80 K. We find a thermal conductivity showing a faster than cubic temperature dependence between 5 and 12 K. …”
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    Observation of Poiseuille flow of phonons in black phosphorus
  10. 230
    “…Coulomb attraction between electrons and holes in a narrow-gap semiconductor or a semimetal is predicted to lead to an elusive phase of matter dubbed excitonic insulator. However, direct observation of such electronic instability remains extremely rare. …”
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    Direct observation of excitonic instability in Ta(2)NiSe(5)
  11. 231
    “…The most potent compound inhibits PLpro with k(inact)/K(I) = 9,600 M(−1) s(−1), achieves sub-μM EC(50) values against three SARS-CoV-2 variants in mammalian cell lines, and does not inhibit a panel of human deubiquitinases (DUBs) at >30 μM concentrations of inhibitor. …”
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    Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2
  12. 232
    “…Here, we introduce a new family of water-soluble binitroxides, dubbed TinyPols, which have a three-bond non-conjugated flexible amine linker allowing sizable couplings between the two unpaired electrons. …”
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    TinyPols: a family of water-soluble binitroxides tailored for dynamic nuclear polarization enhanced NMR spectroscopy at 18.8 and 21.1 T
  13. 233
    “…We analyzed K48- and K63-linked polyubiquitination of MAST1 protein and mapped the interacting domain between USP1 and MAST1 by immunoprecipitation assay. …”
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    CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells
  14. 234
    “…This calcium- and voltage-activated potassium channel, dubbed BK for “Big K” due to its large ionic conductance between 130 and 300 pS in symmetric K(+). …”
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    BK in Double-Membrane Organelles: A Biophysical, Pharmacological, and Functional Survey
  15. 235
    “…The dysregulation of the DUBs may give rise to the occurrence and development of tumors. …”
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    USP13 deubiquitinates and stabilizes cyclin D1 to promote gastric cancer cell cycle progression and cell proliferation
  16. 236
    “…The most potent compound inhibited PLpro with k ( inact ) /K ( I ) = 10,000 M (− 1) s (− 1) , achieved sub-µM EC (50) values against three SARS-CoV-2 variants in mammalian cell lines, and did not inhibit a panel of human deubiquitinases at > 30 µM concentrations of inhibitor. …”
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    Potent and Selective Covalent Inhibition of the Papain-like Protease from SARS-CoV-2
  17. 237
    “…PURPOSE: To develop a new approach to 2D turbo spin ‐echo (TSE) imaging using annular spiral rings with a retraced in/out trajectory, dubbed “SPRING‐RIO TSE”, for fast T(2)‐weighted brain imaging at 3T. …”
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    SPRING‐RIO TSE: 2D T(2)‐Weighted Turbo Spin‐Echo brain imaging using SPiral RINGs with retraced in/out trajectories
  18. 238
    “…The most potent compound inhibited PLpro with k(inact)/K(I) = 10,000 M(− 1) s(− 1), achieved sub-μM EC(50) values against three SARS-CoV-2 variants in mammalian cell lines, and did not inhibit a panel of human deubiquitinases at > 30 μM concentrations of inhibitor. …”
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    Potent and Selective Covalent Inhibition of the Papain-like Protease from SARS-CoV-2
  19. 239
    “…This is further supported by the Tau307–326K and Tau341–378K peptides’ competitive inhibition of Tau binding with USP10, attenuating Tau hyperphosphorylation and Tau deubiquitination. …”
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    USP10 deubiquitinates Tau, mediating its aggregation
  20. 240
    “…The ChemSpider dictionary of ca. 80 k names was only a 1/3 to a 1/4 the size of Chemlist at around 300 k. …”
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    Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining
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