Mostrando 141 - 160 Resultados de 277 Para Buscar 'Dub K', tiempo de consulta: 0.17s Limitar resultados
  1. 141
    “…We identified a functional relationship between increased Dot1 dosage and loss of the DUB module of the SAGA co-activator complex, which deubiquitinates H2Bub1 and thereby negatively regulates H3K79 methylation. …”
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    Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism
  2. 142
    “…Here we show that the DUB activity of OTU11 and OTU12 towards K63-linked ubiquitin is stimulated by binding to lipid membranes containing anionic lipids. …”
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    Lipid-mediated activation of plasma membrane-localized deubiquitylating enzymes modulate endosomal trafficking
  3. 143
    “…Deubiquitinating enzymes (DUBs) are important regulators of ubiquitin signaling. …”
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    Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability
  4. 144
    “…USP9X is a conserved deubiquitinase (DUB) that regulates multiple cellular processes. …”
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    Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X
  5. 145
    “…Additionally, when combined with RDRP, the DUB activity of Et-OTU towards K48- and K6-linked chains was significantly enhanced. …”
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    An OTU deubiquitinating enzyme in Eimeria tenella interacts with Eimeria tenella virus RDRP
  6. 146
    “…Marek’s disease virus (MDV) encodes a viral DUB that plays an important role in the MDV pathogenicity. …”
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    Marek’s Disease Virus Regulates the Ubiquitylome of Chicken CD4(+) T Cells to Promote Tumorigenesis
  7. 147
    “…The linear ubiquitin (Ub) chain assembly complex (LUBAC) is an E3 ligase that specifically assembles Met1-linked (also known as linear) Ub chains that regulate nuclear factor κB (NF-κB) signaling. Deubiquitinases (DUBs) are key regulators of Ub signaling, but a dedicated DUB for Met1 linkages has not been identified. …”
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    OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin
  8. 148
    “…Furthermore, our findings of a congenital human disorder caused by a defective DUB protein that functions in endocytosis, implicates ubiquitin-conjugate aggregation and elevated apoptosis as factors potentially influencing the progressive neuronal loss underlying MIC-CAP.…”
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    Mutations in STAMBP, encoding a deubiquitinating enzyme, cause Microcephaly-Capillary Malformation syndrome
  9. 149
    “…METHODS: Human deubiquitnase (DUB) siRNA library was used to screen the specific DUB, named PSMD14, involved in BMP6 signaling pathway. …”
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    The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway
  10. 150
    “…The half-life of the Bax protein was determined by performing the site-directed mutagenesis of putative ubiquitination sites on Bax (K128R, K189R, and K190R). Of these, Bax (K128R and K190R) showed less ubiquitination; therefore, we compared the half-life of Bax (WT) and Bax K mutant forms in vitro. …”
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    Deubiquitinating Enzyme USP12 Regulates the Pro-Apoptosis Protein Bax
  11. 151
    “…MINDY1 and MINDY2 are members of the MINDY family of deubiquitinases (DUBs) that have exquisite specificity for cleaving K48-polyUb, yet we have a poor understanding of their catalytic mechanism. …”
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    Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2
  12. 152
    “…Although it is well-known that the adaptor protein Imd undergoes K63-linked ubiquitination to activate the downstream signaling cascades, its involvement with K48-linked ubiquitination and what is responsible for controlling this modification remain largely unknown. …”
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    CG4968 positively regulates the immune deficiency pathway by targeting Imd protein in Drosophila
  13. 153
    “…PLpro moonlights as a deubiquitinating (DUB) and deISGylating enzyme, enabling adaptation of a DUB high throughput (HTS) screen to identify PLpro inhibitors. …”
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    Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors
  14. 154
    por Seyoum Tola, Fikadu
    Publicado 2023
    “…Additionally, viruses have the ability to encode deubiquitinating (DUB)-active proteins that can boost viral replication through both direct and indirect means. …”
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    The Role of Ubiquitin-Proteasome System in the Pathogenesis of Severe Acute Respiratory Syndrome Coronavirus-2 Disease
  15. 155
    “…Termination of nuclear NF-κB heterodimer RelA/p50 activity is regulated by the ubiquitin-RING-ligase complex elongin-cullin-suppressor of cytokine signalling 1 (ECS(SOCS1)), which leads to K48-ubiquitinylation and degradation of RelA. We found that deubiquitinylase (DUB) ubiquitin specific protease 48 (USP48), which interacts with the COP9 signalosome (CSN) subunit CSN1, stabilises RelA by deubiquitinylation and thereby promotes the transcriptional activity of RelA to prolong de novo synthesis of DUB A20 in H. pylori infection. …”
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    USP48 and A20 synergistically promote cell survival in Helicobacter pylori infection
  16. 156
    “…In the ubiquitin‒proteasome system (UPS), deubiquitinases (DUBs) are potential therapeutic targets for various tumors. …”
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    The deubiquitinating enzyme STAMBP is a newly discovered driver of triple-negative breast cancer progression that maintains RAI14 protein stability
  17. 157
    “…Mass spectrometric profiling revealed that most DUBs examined have broad selectivity, whereas a subset displays a clear preference for recognizing noncanonical over K48/K63 Ub linkages. …”
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    Deubiquitinating Enzyme Specificity for Ubiquitin Chain Topology Profiled by Di-Ubiquitin Activity Probes
  18. 158
    “…We modified Ubl–NHNH(2) with various thiol-reactive electrophiles that couple selectively with E2s and DUBs. The ease of modification enables the rapid generation and screening of ubiquitin probes with various C-terminal truncations and warheads for the selection of the most suitable combination for a given E2 or DUB.…”
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    Installation of electrophiles onto the C-terminus of recombinant ubiquitin and ubiquitin-like proteins
  19. 159
    “…In a LQT1 cardiomyocyte model, enDUB treatment restored delayed rectifier K(+) currents and normalized action potential duration. …”
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    Targeted deubiquitination rescues distinct trafficking-deficient ion channelopathies
  20. 160
    por Shao, Hua-Sheng
    Publicado 2012
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    HELAC-Onia: an automatic matrix element generator for heavy quarkonium physics
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